| Not Yet Recruiting | Endoscopic Cardial Constriction Ligation (ECCL) for Refractory GERD Using a Disposable Endoscope NCT07176221 | Ying Zhu | N/A |
| Not Yet Recruiting | Effect of Breathing Training on Symptoms of Gastroesophageal Reflux Disease NCT07179250 | Changhua Christian Hospital | N/A |
| Recruiting | Performance and Safety of Afluxin® in Patients With Gastroesophageal Reflux Disease NCT06984484 | Devintec Sagl | N/A |
| Not Yet Recruiting | A Study to Compare PK/PD Characteristics and Safety Profiles Between AD-120 and AD-120A NCT06916130 | Addpharma Inc. | Phase 1 |
| Not Yet Recruiting | EFFICACY OF INSPIRATORY MUSCLE TRAINING ASSOCIATED WITH MANUAL TECHNIQUES IN INDIVIDUALS WITH GERD NCT06871163 | Universidade Federal de Pernambuco | N/A |
| Recruiting | Clinical Study Evaluating The Role of Vonoprazan Versus Pantoprazole in Patients With Gastroesophageal Reflux NCT06564246 | Tanta University | Phase 4 |
| Withdrawn | Transoral Incisionless Fundoplication (TIF) for Laryngopharyngeal Reflux (LPR) Patients NCT05579587 | Brigham and Women's Hospital | — |
| Recruiting | A Study to Check the Safety of Dexlansoprazole and Learn if it Can Treat Symptomatic Nonerosive Gastroesophage NCT02616302 | Takeda | Phase 2 |
| Recruiting | Post-Market Registry for the Evaluation of RefluxStop in GERD Treatment NCT05870163 | Implantica CE Reflux Ltd. | — |
| Active Not Recruiting | Evaluation of the Clinical Course of NERD and Assessment of the Esophageal Mucosa Resistance NCT07174882 | I.M. Sechenov First Moscow State Medical University | — |
| Completed | Evaluation of the Effectiveness of the Ezisurg Stapling (Ezi Endo Lite) During Laparoscopic Nissen Sleeve Gast NCT07344935 | Ezisurg Medical Co. Ltd. | N/A |
| Completed | Combined Scalp and Ear Acupuncture in Patients With Proton Pump Inhibitor- Dependent Gastroesophageal Reflux D NCT04660019 | Taipei Medical University WanFang Hospital | N/A |
| Unknown | Study to Evaluate the Performance and Safety of the MARIAL® in Association With PPI Versus PPI Alone NCT04130659 | Nekkar Lab Srl | N/A |
| Completed | Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Prot NCT03561883 | Ironwood Pharmaceuticals, Inc. | Phase 3 |
| Terminated | Efficacy and Safety of DLBS2411 in the Management of GERD NCT03367195 | Dexa Medica Group | Phase 3 |
| Terminated | A Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Pr NCT03561090 | Ironwood Pharmaceuticals, Inc. | Phase 3 |
| Completed | Retrospective Observational Study on GERD Management in General Hospitals in Korea NCT06974903 | Chong Kun Dang Pharmaceutical | — |
| Active Not Recruiting | Development of Machine Learning Models to Predict Postoperative GERD Symptom Resolution After Laparoscopic Nis NCT06862037 | Korea University Anam Hospital | — |
| Terminated | An Investigation of the EndoStim® Lower Esophageal Sphincter (LES) Stimulation System for the Treatment of Ref NCT02749071 | EndoStim Inc. | N/A |
| Completed | The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity NCT02689999 | Neutec Ar-Ge San ve Tic A.Ş | Phase 4 |
| Completed | Experimental Study to Determine the Effects of Human Refluxate on Macrophage Phenotype and Its Correlation Wit NCT02699060 | Ivashkin Vladimir Trofimovich | N/A |
| Unknown | Medigus Ultrasonic Surgical Endostapler (MUSE) Registry NCT02366169 | Medigus Ltd | — |
| Recruiting | Indiana University Gastrointestinal Motility Diagnosis Registry NCT04506593 | Indiana University | — |
| Completed | Mucosal Impedance in Pediatric Population NCT02320981 | Vanderbilt University Medical Center | — |
| Completed | Assessment of Esophageal Epithelium Integrity With Mucosal Impedance NCT02318862 | Vanderbilt University Medical Center | N/A |
| Completed | Response to Supplement and Placebo in GERD NCT01915173 | Beth Israel Deaconess Medical Center | N/A |
| Completed | A Post-Approval Study of the LINX® Reflux Management System NCT01940185 | Torax Medical Incorporated | — |
| Completed | The EndoGastric Solutions TEMPO Trial NCT01647958 | EndoGastric Solutions | N/A |
| Completed | Anthropometry in Gastroesophageal Reflux Disease and Esophageal Injury NCT01570842 | Mayo Clinic | N/A |
| Completed | RESULT (REflux Surgery in Lung Transplantation) Preliminary Study Protocol NCT01406210 | Duke University | — |
| Completed | Proton Pump Inhibitors and Risk of Community-acquired Pneumonia NCT02555852 | Canadian Network for Observational Drug Effect Studies, CNODES | — |
| Completed | Is the Neosquamous Epithelium "Normal" Following Endoscopic Ablation of Dysplastic Barrett's Esophagus? NCT01373125 | University of North Carolina, Chapel Hill | — |
| Completed | Racial Disparity in Barrett's Esophagus NCT01374074 | University of North Carolina, Chapel Hill | — |
| Terminated | Retrospective TIF Study for Treatment of Gastroesophageal Reflux Disease (GERD). The RetroTIF Study NCT01327963 | EndoGastric Solutions | N/A |
| Unknown | Comparison of Nexium Versus Secretol in the Healing and Controlling of Symptoms in GERD Patients With Severe E NCT01129713 | Effexus Pharmaceutical | Phase 1 / Phase 2 |
| Withdrawn | Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using Esoph NCT01025739 | University of Alberta | Phase 2 |
| Completed | To Learn How Bone Structure and Bone Mass Change After Long-term PPI Use NCT01306799 | University of Pennsylvania | — |
| Completed | Epidemiology of Barrett's Esophagus: A Population Based Study NCT01286155 | Mayo Clinic | — |
| Terminated | Endoscopic Fundoplication Versus Proton Pump Inhibitors for GERD Treatment NCT00857597 | University of Pittsburgh | Phase 3 |
| Completed | A Study of the Safety and Effectiveness of Rabeprazole for the Treatment of Gastroesophageal Reflux Disease (G NCT00787891 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |
| Completed | Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis NCT01389401 | Faculdade de Ciências Médicas da Santa Casa de São Paulo | — |
| Completed | Correlation of Oropharyngeal Pepsin and Gastroesophageal (GE) Reflux NCT01091805 | Wake Forest University Health Sciences | — |
| Completed | Partial Response to Proton Pump Inhibitors (PPI) Treatment: The Cost to Society and the Burden to the Patient NCT00795093 | AstraZeneca | — |
| Completed | TAK-438 - Safety, Blood Levels & Effects of Repeated Doses NCT02141711 | Takeda | Phase 1 |
| Completed | Rabeprazole Extended-Release 50 mg vs. Ranitidine 150 mg for Maintenance of Healed Erosive Gastroesophageal Re NCT00838526 | Eisai Inc. | Phase 3 |
| Completed | Rabeprazole Extended Release 50 mg Versus Ranitidine 150 mg for Maintenance of Healed Erosive Gastroesophageal NCT00839306 | Eisai Inc. | Phase 3 |
| Completed | Safety and Efficacy the Medigus SRS Endoscopic Stapling System in Gastroesophageal Reflux Disease (GERD) NCT00734747 | Aviel Roy-Shapira, M.D. | Phase 3 |
| Completed | Rabeprazole Extended-Release, 50 mg, Versus Esomeprazole, 40 mg, for Healing and Symptomatic Relief of Moderat NCT00658775 | Eisai Inc. | Phase 3 |
| Completed | Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Moderate to NCT00658528 | Eisai Inc. | Phase 3 |
| Completed | Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Mild to Mod NCT00658632 | Eisai Inc. | Phase 3 |
| Completed | A Study of Single and Multiple Doses of Rabeprazole in Pediatric Patients With Gastroesophageal Reflux Disease NCT00747526 | Janssen Research & Development, LLC | Phase 1 |
| Terminated | Safety and Efficacy of AST-120 in Patients With GERD Who Continue to be Symptomatic on a Standard Dose of PPI NCT00587275 | Ocera Therapeutics | Phase 2 |
| Completed | Optimal Dosing of Omeprazole in Neonates NCT01657578 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Completed | Phase 3/Safety & Efficacy of Esomeprazole in Infants NCT00468559 | AstraZeneca | Phase 3 |
| Completed | Symptom Improvements in Gastroesophageal Reflux Disease (GERD) Patients NCT00394472 | AstraZeneca | Phase 2 |
| Completed | Effect of Pantoprazole on the Symptoms of Acid Reflux Disease in Adult Patients (BY1023/M3-341) NCT00312806 | Takeda | Phase 3 |
| Terminated | A Study to Determine the Effectiveness of Endoscopic Full-Thickness Plication for the Treatment of GERD NCT00575822 | NDO Surgical, Inc. | N/A |
| Completed | Endoscopic Full-Thickness Plication for the Treatment of GERD: Long-Term Multicenter Results NCT00587392 | NDO Surgical, Inc. | — |
| Completed | Esomeprazole for Treatment of GERD in Pediatric Patients NCT00228527 | AstraZeneca | Phase 4 |
| Completed | Safety of Daily Dose Esomeprazole for GERD for Pediatric and Adolescent Patients NCT00241501 | AstraZeneca | Phase 3 |
| Completed | Assessment of the Role of Tegaserod Therapy in the Management of Gastroesophageal Reflux Disease (GERD) Sympto NCT00171483 | Novartis | Phase 3 |
| Completed | Study to Assess Management Strategies for the Use of Esomeprazole (Nexium) in Helicobacter Pylori Infected Pat NCT00574925 | University of Zurich | Phase 4 |
| Completed | Assessment of the Effects of Tegaserod in the Management of Gastroesophageal Reflux Disease (GERD) in Patients NCT00171418 | Novartis | Phase 3 |
| Completed | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With NCT00628342 | AstraZeneca | Phase 4 |
| Completed | Long-term Pantoprazole Trial in Patients With Symptoms of Chronic Acid Peptic Complaints (BY1023/VMG-708) NCT00261300 | Takeda | Phase 3 |
| Recruiting | Esophageal Cancer Risk Registry NCT00260585 | University of Pittsburgh | — |
| Completed | A Study on the Effectiveness of Laparoscopic Fundoplication on Extraesophageal Manifestations of Gastroesophag NCT01324986 | General Public Hospital Zell am See | N/A |