| Not Yet Recruiting | A Study to Evaluate the Safety and Tolerability of Intravenous Stemis™ in Elderly Subjects With Mild to Modera NCT07462819 | Ji Yan Biomedical Co., Ltd. | Phase 1 |
| Recruiting | Multimodal Prehabilitation of Frail Patients Undergoing Elective Knee or Hip Replacement NCT07465159 | University of Iceland | N/A |
| Not Yet Recruiting | COMPARISON OF THE EFFICACY OF CONVENTIONAL EXERCISE AND PILATES IN PRE-FRAIL AND FRAIL OLDER ADULTS NCT07458048 | Istanbul University - Cerrahpasa | N/A |
| Not Yet Recruiting | Longitudinal Assessment of Maximal Inspiratory Pressure and Functional Capacity Following Inspiratory Muscle T NCT07328334 | Universidad Francisco de Vitoria | N/A |
| Active Not Recruiting | Longitudinal Ultrasound Assessment of Diaphragmatic and Respiratory Muscle Function Following Respiratory Musc NCT07258615 | Universidad Francisco de Vitoria | N/A |
| Recruiting | Real World Evidence to Assess the Value of a Digital Care Coordination and Monitoring Program for Supporting C NCT07348081 | Fondation Hôpital Saint-Joseph | N/A |
| Recruiting | Physical Performance Assessment in Kidney Transplant Evaluation NCT07338929 | University Hospital, Martin | — |
| Not Yet Recruiting | Effectiveness of Immersive Virtual Reality Combined With Occupational Therapy in Reducing Fall Risk and Frailt NCT07060677 | Universidad Rey Juan Carlos | N/A |
| Completed | Design and Validation of FEXO: A Playful Exercise Program for Institutionalized Frail Older Adults NCT07133581 | Cardenal Herrera University | N/A |
| Completed | Fun Exercise Intervention for Older Adults to Improve Intrinsic Capacity and Motivation NCT07133568 | Cardenal Herrera University | N/A |
| Not Yet Recruiting | PREhabilitation of Frail Elderly PAtients Undergoing majoR surgEry at HOME (PREPARE-HOME) Using Smart Wearable NCT06633614 | Singapore General Hospital | N/A |
| Completed | A Nutrition Care Model for Frailty Prevention in the Elderly Based on Design Thinking NCT07504419 | Suh-Ching, Yang | N/A |
| Recruiting | Cognitive Groove (Brought to You by GERAS DANCE) NCT06870149 | McMaster University | N/A |
| Active Not Recruiting | TrackFrailty Project NCT06812286 | University of Beira Interior | N/A |
| Active Not Recruiting | Frailty and Outcomes in Older Heart Failure Patients With Ejection Fraction >40% NCT07071142 | Duyen Nguyen Hoang Mai | — |
| Active Not Recruiting | Arlington Longitudinal Optimal Healthy Aging Study (ALOHA) NCT07180147 | Marymount University | — |
| Not Yet Recruiting | Effectiveness of Post-Hospital Discharge Housing Counselling to Support Geriatric Patients in Staying At Home: NCT06842719 | Maximilian König | N/A |
| Recruiting | Modified Essential Frailty Toolset in Older Adults Undergoing Major Elective Surgery NCT07452263 | University of Iceland | — |
| Recruiting | Validity of Frailty Screening Tools as a Measure for Postoperative Outcomes NCT07367828 | University of Iceland | — |
| Recruiting | The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging NCT06208527 | Haukeland University Hospital | Phase 2 |
| Completed | The Impact of Transcutaneous Vagal Nerve Stimulation on Frailty Syndrome in Older Adults NCT07416708 | Balnear and Rehabilitation Sanatorium Techirghiol | N/A |
| Recruiting | Optimizing Prevention of Hospital-Acquired Disability Through Multidomain Interventions NCT06611228 | University of Milano Bicocca | N/A |
| Active Not Recruiting | Prescribing Outcomes of a GP-Targeted Deprescribing Educational Intervention: A Cluster Randomized Trial NCT06470308 | University of Crete | N/A |
| Active Not Recruiting | One Year of Velocity-based Resistance Training in Older People Living in Nursing Homes NCT07027397 | University of Castilla-La Mancha | N/A |
| Active Not Recruiting | Effect of Silkworm Pupa Tablets in Gastrointestinal Malignancies at Nutritional Risk Following Radical Surgery NCT06551675 | Xiaosun Liu, MD | N/A |
| Recruiting | Nicotinamide Supplementation Improves Physical Performance in Older Adults at Risk of Falls NCT06465602 | University of Chile | Phase 2 |
| Completed | Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery NCT06140797 | Xuanwu Hospital, Beijing | N/A |
| Withdrawn | Implementation of the Integrated Care of Older People App and ICOPE Monitor in Primary Care (ICOPE) NCT04413877 | University of Liege | — |
| Completed | AGE SELF CARE: Promoting Healthy Aging Through a Group Visit Program NCT06079762 | Brigham and Women's Hospital | N/A |
| Completed | Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults NCT05961319 | University of Alberta | — |
| Not Yet Recruiting | SHIP-AGE: Frailty, Renal Function, and Multi-component Primary Care in Rural Mecklenburg-Western Pomerania NCT05962203 | University Medicine Greifswald | N/A |
| Recruiting | Comparison of Frailty Screening Performance and Predictive Validity of Adverse Health Outcomes in Breast Cance NCT06467149 | Ju Qiu | — |
| Completed | Effectiveness of a Home-Based Multicomponent Exercise Program With Digital Support in Community-Dwelling Older NCT06936865 | Spanish National Research Council | N/A |
| Recruiting | Prehabilitation in Pancreatic Surgery NCT06069297 | IRCCS San Raffaele | N/A |
| Completed | Targeted Physical Function Exercises on Frailty and Falls Management in Pre-Frail Community-Dwelling Older Adu NCT06731712 | Hellenic Mediterranean University | N/A |
| Unknown | Effectiveness of a Multifactorial Intervention in Frailty Individuals With HIV Infection: HIDRA360 NCT05832164 | Hospital Costa del Sol | N/A |
| Recruiting | The CohorFES: a Prospective Study of Frailty and Dependence NCT06965972 | Parc de Salut Mar | — |
| Recruiting | Structured Program of Exercise for Recipients of Kidney Transplantation NCT04954690 | University of California, San Francisco | N/A |
| Recruiting | COVID-19 Outcome Prediction Algorithm NCT05471011 | University of California, Los Angeles | — |
| Unknown | Effect of a Multicomponent Intervention on Functional Capacity After Hip Fracture NCT05435534 | Fundacion Miguel Servet | N/A |
| Completed | Cystic Fibrosis and Frailtyh What's in Common? NCT06020547 | Federico II University | — |
| Unknown | Application of a Nutritional Counseling Program on the Frailty of Older Adults in the Mexican Population NCT05304429 | Instituto Tecnologico y de Estudios Superiores de Monterey | N/A |
| Completed | The Effectiveness of Training Using Exergaming on Selected Physical and Psychological Parameters in a Populati NCT07036224 | Wroclaw Medical University | N/A |
| Unknown | Translation and Cultural Adaptation of the Groningen Frailty Indicator (GFI) in Patients With Hip Fracture NCT05091645 | University of Thessaly | — |
| Completed | Validity of an App to Detect Frailty and Sarcopenia Syndromes in Elderly NCT05148351 | Catholic University of Murcia | — |
| Unknown | Effectiveness of a Multimodal Intervention on Function in Older Frail People With Diabetes in Latinamerican NCT04504968 | Consorcio Centro de Investigación Biomédica en Red (CIBER) | N/A |
| Completed | Loss of Independence - a Rapid Alternative to Frailty Screening in a Swedish ED Setting NCT04888884 | University Hospital, Linkoeping | — |
| Unknown | Mesenchymal Stem Cells for The Treatment of Frailty Syndrome NCT04914403 | Meridigen Biotech Co., Ltd. | Phase 1 |
| Completed | Efficacy of WB-EMS in Frail Older People NCT04967534 | University of Erlangen-Nürnberg Medical School | N/A |
| Unknown | Characterising Frailty Using Magnetic Resonance Imaging NCT04612686 | University of Nottingham | — |
| Completed | Analysis of Frailty Syndrome Within the Framework of the Innovation Fund Project PRÄP-GO (ANA-PRÄP-GO) NCT04880824 | Charite University, Berlin, Germany | — |
| Completed | Frailty Screening in the Swedish Emergency Department Setting NCT04877028 | University Hospital, Linkoeping | — |
| Unknown | Frailty Syndrome of Post-cancer Treatment Eldery Patients NCT04746768 | University Hospital, Grenoble | N/A |
| Unknown | Digital Intelligent Assistant for Nursing Application NCT04393272 | Geriatrische Klinik St. Gallen | — |
| Completed | Frailty Trajectories and Their Association With Health Outcomes NCT05793229 | Nanjing Medical University | — |
| Unknown | Salutogenic Frailty Prevention Program for Women Aged 55 Years and Over NCT04787432 | Istanbul University - Cerrahpasa | N/A |
| Recruiting | Frailty and Physician Modified Fenestrated Endograft for Thoracoabdominal Aortic Pathologies NCT04524247 | University of Southern California | N/A |
| Completed | Functioning of Elder Muscle; Understanding Recovery NCT04764617 | University of Nottingham | — |
| Completed | Prevalence of Two Major Geriatric Syndromes: Sarcopenia and Frailty NCT04146844 | Goztepe Training and Research Hospital | — |
| Unknown | Study of the Association Between Presbycusis With the Incidence of Frailty NCT04360109 | Universidad Europea de Madrid | — |
| Completed | Multidisciplinary Prehabilitation to Improve Frailty and Functional Capacity in High-risk Elective Surgical Pa NCT05668221 | Chinese University of Hong Kong | — |
| Unknown | Maintaining and imPrOving the intrinSIc capaciTy Involving Primary Care and caregiVErs NCT04592146 | Hospital Universitario Getafe | N/A |
| Completed | Modified Fraility Index in Patients Undergoing Arthroplasty NCT05424575 | Ankara University | — |
| Withdrawn | Altering Mechanisms of Frailty in Persons Living With HIV Aged 50 to 65 NCT04321603 | University of Maryland, Baltimore | N/A |
| Completed | Frailty in Patients With Cirrhosis: Prognostic Value of the Phase Angle in Hospitalized Patients and Effect of NCT04243148 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | N/A |
| Withdrawn | Study to Explore the Safety and Feasibility of Allogeneic Young Plasma Infusion in Older Adults NCT04241159 | Wake Forest University Health Sciences | EARLY_Phase 1 |
| Unknown | Ambulatory Blood Pressure in HFPEF Outcomes Global Registry NCT04065620 | Hospital Clinic of Barcelona | — |
| Unknown | Cardiac Rehabilitation and Additional Physical Training in Elderly Patients After Acute Coronary Syndrome NCT04768283 | Lithuanian University of Health Sciences | N/A |
| Recruiting | Comprehensive Geriatric Assessment in Kidney Transplantation NCT06104696 | Institute for Clinical and Experimental Medicine | — |
| Completed | Feasibility of an Extended Test Battery and Influencing Factors for Detecting Frailty NCT04190329 | Charite University, Berlin, Germany | — |
| Recruiting | Movement and Behaviours Measurement Study NCT04173715 | University of Castilla-La Mancha | — |
| Completed | Adaptation and Validation of Frailty Scales in Intensive Care Units in Spain NCT04830865 | Hospital Universitario Getafe | — |
| Unknown | Successful Aging and Frailty NCT03963050 | Universita di Verona | N/A |
| Enrolling By Invitation | The Correlation and Intervention of Intestinal Flora and Frailty in the Elderly NCT03995342 | Xijing Hospital | N/A |
| Unknown | Validation of the Screening Instrument: PRISMA-7 for Frailty Among Elderly Hospitalized Danes NCT03999047 | Region Zealand | — |
| Completed | Protocol for Multi-site Evaluation of New Community-based Frailty Programme NCT04866316 | Geriatric Education and Research Institute | — |
| Completed | Ultrasound Assessment of a Physical Exercise in The Water in a Frail Population NCT03955302 | University of Valencia | N/A |
| Unknown | Promoting Health LongevIty Through Mitigation and Prevention of Frailty in Community-dwelling Elderly (Pro-LIF NCT04656938 | Sengkang General Hospital | N/A |
| Completed | Feasibility and Effectiveness of an Additional Resistance and Balance Training in Cardiac Rehabilitation of Ol NCT04234087 | Lithuanian University of Health Sciences | N/A |
| Unknown | Health Status and Its Socio-economic Covariates of the Older Population in Poland - the Nationwide PolSenior2 NCT04026815 | Medical University of Gdansk | — |
| Completed | Pre-frailty and Rehospitalization in Cardiac Surgery NCT03949439 | Instituto Dante Pazzanese de Cardiologia | — |
| Recruiting | Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People NCT04518423 | The Opole University of Technology | — |
| Unknown | Development of an Intelligent POWER Rehabilitation Cluster Machine and Its Clinical Testing and Assessment NCT02685839 | Taipei Veterans General Hospital, Taiwan | N/A |
| Completed | Clinical Intervention in Frail Older People (FRAILCLINIC) NCT02643069 | Hospital Universitario Getafe | N/A |
| Completed | Ghrelin Plus Strength Training in Frail Elderly Study NCT01898611 | University of Pennsylvania | Phase 2 |
| Withdrawn | Study to Assess the Safety and Effects of Autologous Adipose-Derived Stem Cells in Patients With Frailty Syndr NCT01501461 | Ageless Regenerative Institute | N/A |