| Not Yet Recruiting | Clinical Study on Noninvasive Evaluation of Ivonescimab Antibody Distribution and Expression in Esophageal Can NCT07440212 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | — |
| Recruiting | Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA NCT07070466 | Massachusetts General Hospital | Phase 2 |
| Recruiting | A Trial of the Combination of Afatinib and Palbociclib in Previously Treated Advanced Esophageal Squamous Cell NCT06753747 | West China Hospital | Phase 1 / Phase 2 |
| Not Yet Recruiting | Tislelizumab Combined With Chemotherapy for Resectable Esophageal Squamous Cell Carcinoma Followed by CRT or S NCT07046221 | Fujian Cancer Hospital | Phase 2 |
| Not Yet Recruiting | Tislelizumab Combined With Chemotherapy for the Perioperative Treatment of Esophageal Squamous Carcinoma NCT07019181 | The First Affiliated Hospital of Xiamen University | Phase 2 |
| Recruiting | Multimodal Deep Learning for Predicting Treatment Response to Neoadjuvant Chemoimmunotherapy in Esophageal Can NCT07063901 | Central South University | — |
| Not Yet Recruiting | Tislelizumab as Single-Agent Neoadjuvant Immunotherapy in Resectable Esophageal Squamous Cell Carcinoma NCT06692270 | Fujian Cancer Hospital | Phase 2 |
| Recruiting | Target-specific immunoPET Imaging of Digestive System Carcinoma NCT06715839 | RenJi Hospital | N/A |
| Recruiting | Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer NCT06097078 | Aesculap AG | — |
| Active Not Recruiting | Oncometabolome and MALDI-MSI in Upper GI Carcinomas - Chemosensitivity in Esophageal Carcinoma NCT06642506 | Ludwig-Maximilians - University of Munich | — |
| Completed | Enhanced Assistance During Radiotherapy for Unmet Essential Needs NCT06582849 | Washington University School of Medicine | N/A |
| Recruiting | HER2 Status in Esophagogastric Adenocarcinoma and Its Associations With Patient's Clinicopathological Outcomes NCT06550063 | St. James's Hospital, Ireland | — |
| Withdrawn | Phase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG With Entinostat and Nivolumab as A NCT05898828 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Recruiting | Multicenter Cohort Study of ESD and Chemo-radiotherapy for High-risk Early-stage Esophageal Cancer NCT06385717 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Recruiting | Neoadjuvant Comprehensive Treatment for Unresectable Esophageal Cancer NCT06430658 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 2 |
| Recruiting | Goal-directed Enteral Nutritional Perioperative Management NCT06510543 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | N/A |
| Active Not Recruiting | Combination of Cadonilimab and Chemoradiotherapy in Esophageal Cancer (EC-CRT-006) NCT06143748 | Sun Yat-sen University | Phase 2 |
| Unknown | Exosome-based Liquid Biopsies for Upper Gastrointestinal Cancers Diagnosis NCT06278064 | Beijing Friendship Hospital | — |
| Recruiting | Functional Imaging to Identify Radiosensitive Esophageal Cancer - a Biomarker Validation Study NCT06189898 | Sebastian Zschaeck | — |
| Enrolling By Invitation | A Clinical Study of Non-curative Resection Plus Radiotherapy After Endoscopic ESD for Superficial Esophageal S NCT06160557 | Xiaomeng Zheng | — |
| Not Yet Recruiting | Comparison of Long-term Survival and Quality of Life After Minimally Invasive Esophagectomy Versus Open Esopha NCT06147180 | Qilu Hospital of Shandong University | — |
| Recruiting | Acupuncture for Oxaliplatin-induced Peripheral Neuropathy in Gastro-intestinal Cancer Patients NCT05850130 | GERCOR - Multidisciplinary Oncology Cooperative Group | N/A |
| Recruiting | Clinical Study of CEA Targeting Chimeric Antigen Receptor T Lymphocytes（CAR-T） for CEA Positive Advanced Malig NCT06126406 | Chongqing Precision Biotech Co., Ltd | Phase 1 |
| Recruiting | Clinical Study of CEA-targeted CAR-T Therapy for CEA-positive Advanced/Metastatic Malignant Solid Tumors NCT06010862 | Chongqing Precision Biotech Co., Ltd | Phase 1 |
| Recruiting | Prospective Screening and Differentiating Common Cancers Using Peripheral Blood Cell-Free DNA Sequencing NCT06036563 | Air Force Military Medical University, China | — |
| Terminated | A Phase 1 Clinical Trial of AUR106 in Patients With Relapsed Advanced Malignancies NCT05861947 | Aurigene Discovery Technologies Limited | Phase 1 |
| Recruiting | A Clinical Trial Targeting CEA Chimeric Antigen Receptor T (CAR-T) for CEA Positive Advanced Malignant Solid T NCT06043466 | Chongqing Precision Biotech Co., Ltd | Phase 1 |
| Unknown | Impact of Dose to Cardiac Substructures on Survival in Patients With Esophageal Cancer Treated With Radiothera NCT05996276 | University Hospital, Brest | — |
| Recruiting | Supercharged TRAM Evaluation in Cervical Esophagogastroplasty After Esophagectomy NCT05954702 | Instituto do Cancer do Estado de São Paulo | N/A |
| Recruiting | Individualized Dose Escalation of 5-FU for Gastrointestinal Cancer NCT05780684 | Dartmouth-Hitchcock Medical Center | N/A |
| Recruiting | CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esoph NCT05187182 | Washington University School of Medicine | Phase 1 |
| Unknown | The IIT Study of Evaluation of P-IL-2 Single Agent and With Anti-PD-1 NCT05829057 | Zhejiang University | Phase 1 |
| Completed | A Liquid Biopsy for High-risk Pre-cancer Screening of Esophageal Adenocarcinoma NCT06381583 | City of Hope Medical Center | — |
| Unknown | Utility and Usability of ActivSight™ Laser Speckle Imaging in Visualization of Tissue Perfusion and Blood Flow NCT05591053 | Activ Surgical | N/A |
| Unknown | Rhomboid Intercostal and Subserratum Plane Block for Minimally Invasive Esophagectomy NCT06092944 | Luo Fuchao | N/A |
| Unknown | Acupuncture Effect on Dumping Syndrome in Esophagus Cancer Patients With Feeding Jejunostomy NCT05801666 | China Medical University, Taiwan | N/A |
| Unknown | Clinical Trial of Qizhu Yuling Prescription in the Prevention and Treatment of Esophagus Cancer NCT05626309 | Jie Li | N/A |
| Suspended | Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbet NCT05400122 | David Wald | Phase 1 |
| Unknown | Follow-up Strategy for Esophageal Cancer Patients NCT06045715 | Sun Yat-sen University | — |
| Unknown | Predictive Model to Early Diagnosis of Anastomotic Leak After Esophagectomy and Gastrectomy. NCT05390684 | Hospital Universitario La Fe | — |
| Completed | Neoadjuvant Immunotherapy Combined With Chemotherapy in Patients With Locally Advanced ESCC NCT05807542 | Shanghai Zhongshan Hospital | Phase 2 |
| Unknown | Influence of Different Light Dose on the Adverse Effect of Swallowing for Esophageal Carcinoma NCT05174117 | The First Affiliated Hospital of Henan University of Science and Technology | N/A |
| Recruiting | Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes NCT04907643 | Cedars-Sinai Medical Center | N/A |
| Completed | Sequence and Time-of-day Infusion of immunoCHemotherapy Affect Response in Oesophageal Cancer in the NeOadjuva NCT05615129 | Guangdong Provincial People's Hospital | — |
| Completed | Tumor Antigen-sensitized DC Vaccine As an Adjuvant Therapy for Esophagus Cancer NCT05023928 | Sichuan University | Phase 1 |
| Unknown | High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity NCT04500392 | RenJi Hospital | N/A |
| Completed | The Registry of Oncology Outcomes Associated With Testing and Treatment NCT04028479 | Taproot Health | — |
| Active Not Recruiting | Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors NCT04902872 | Cybrexa Therapeutics | Phase 1 / Phase 2 |
| Active Not Recruiting | Imaging and Blood-Based Biomarkers for the Evaluation of Early Signs of Myocardial Injury After Thoracic Radia NCT05717998 | Ohio State University Comprehensive Cancer Center | — |
| Active Not Recruiting | Chemoradiotherapy Plus Immunotherapy Followed by Surgery for Esophageal Cancer NCT04776590 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 2 |
| Completed | Neoadjuvant Chemotherapy Compared With Surgery for Esophageal Carcinoma NCT05569668 | Henan Cancer Hospital | — |
| Completed | COVID - 19 and Advanced Gastro-intestinal Cancer Treatment NCT04686747 | S.M. Misericordia Hospital | — |
| Unknown | Carrelizumab Combined With Chemotherapy for Adjuvant Therapy of Esophageal Squamous Cell Carcinoma NCT05637268 | Tianjin Medical University Cancer Institute and Hospital | Phase 2 |
| Completed | Study of PD-1 Antibody Combined With Chemoradiotherapy in Oligometastatic Esophageal Cancer NCT04821765 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 2 |
| Completed | Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S NCT04430842 | Quadriga Biosciences, Inc. | Phase 1 |
| Completed | Cost Effectiveness of an Intervention in Hospitalized Patients With Disease-related Malnutrition NCT04188990 | Hospital Galdakao-Usansolo | N/A |
| Active Not Recruiting | Phase II Study of Postoperative Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma (ESO- Shan NCT04764227 | Fudan University | Phase 2 |
| Unknown | A Study of T3011 Administered Via Intratumoral Injection in Patients With Advanced Solid Tumors NCT05602792 | ImmVira Pharma Co. Ltd | Phase 1 / Phase 2 |
| Completed | A Study of PET Scans With the Radioactive Tracer 18F-BMS-986229 in Patients With Esophageal, Stomach, or Gastr NCT04161781 | Memorial Sloan Kettering Cancer Center | — |
| Active Not Recruiting | Radiation Dose Intensification With Accelerated Hypofractionated Intensity Modulated Radiation Therapy and Con NCT04046575 | Washington University School of Medicine | Phase 1 |
| Unknown | Autologous CAR-T/TCR-T Cell Immunotherapy for Solid Malignancies NCT03941626 | Shenzhen BinDeBio Ltd. | Phase 1 / Phase 2 |
| Unknown | Neoadjuvant Chemoradiotherapy Combined With PD-1 Antibody in Locally Advanced Esophageal Cancer NCT04177875 | Tongji Hospital | Phase 2 |
| Recruiting | The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study NCT04075305 | UMC Utrecht | — |
| Completed | Association of Radiochemotherapy and Immunotherapy for the Treatment of Unresectable Oesophageal caNcer NCT03777813 | UNICANCER | Phase 2 |
| Completed | Evaluation of Full-field Coherence Tomography for ex Vivo Staging and Assessment of Superficial Esophageal Squ NCT03467529 | Nantes University Hospital | — |
| Completed | Venous Thromboembolism and Bleeding Risk in Patients With Esophageal Cancer NCT03646409 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Active Not Recruiting | Proton Beam Therapy in the Treatment of Esophageal Cancer NCT03482791 | Washington University School of Medicine | N/A |
| Unknown | Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies NCT03638206 | Shenzhen BinDeBio Ltd. | Phase 1 / Phase 2 |
| Completed | KeyLargo: Pembrolizumab + Oxaliplatin + Capecitabine in Gastric Cancer NCT03342937 | Duke University | Phase 2 |
| Completed | Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Treatment-Refractory NCT03199586 | Novita Pharmaceuticals, Inc. | Phase 1 |
| Completed | High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Gastroscopy Sedated by Propofol NCT03332433 | RenJi Hospital | N/A |
| Unknown | Pre-operative MRI of Esophagus Cancer NCT03347630 | Dromain Clarisse | N/A |
| Terminated | Measuring Cell Free DNA During the Course of Treatment for Esophageal Cancer as a Marker of Response and Recur NCT03108885 | Mayo Clinic | — |
| Completed | Tisotumab Vedotin Continued Treatment in Patients With Solid Tumors. NCT03245736 | Seagen Inc. | Phase 2 |
| Unknown | Radical Resection of Single-hole Inflatable Mediastinal Mirror Synchronization With Laparoscopic Esophageal Ca NCT03657914 | Qingdong Cao | N/A |
| Completed | Definitive (Chemo)Radiotherapy for Patients With Esophageal Cancer - 3JECROG R-01 NCT03298204 | Chinese Academy of Medical Sciences | — |
| Unknown | TTS Esophageal HILZO Stent: A Safety and Feasibility Study NCT03269903 | Radboud University Medical Center | N/A |
| Completed | Prediction of Lymphatic Metastasis in Esophageal Cancer by CT Radiomics NCT03237130 | Peking University Cancer Hospital & Institute | — |
| Terminated | Feasibility Study of Navigated Endoscopy for the Placement of High Dose Rate Brachytherapy Applicators in the NCT03051802 | University Health Network, Toronto | N/A |
| Unknown | The Efficacy and Safety of Caffeic Acid for Esophageal Cancer NCT03070262 | The First Affiliated Hospital of Henan University of Science and Technology | Phase 3 |
| Recruiting | Retrospective Review of Esophageal Cancer at MSKCC NCT05706558 | Memorial Sloan Kettering Cancer Center | — |
| Unknown | Docetaxol Plus Cisplatin Versus 5-Fu Plus Cisplatin as 1st-line Chemotherapy in Advanced ESCC Patients NCT03002064 | Sun Yat-sen University | Phase 3 |
| Unknown | Short-term Starvation vs. Normal Diet Before Chemotherapy of Solid Tumors NCT02607826 | University Hospital Tuebingen | N/A |
| Unknown | Different Anesthetic Managements of Esophageal Resection and Reconstruction NCT02961140 | National Taiwan University Hospital | N/A |
| Recruiting | Chemoradiation Versus Esophagectomy for Locally Advanced Esophageal Cancer NCT02972372 | The First Affiliated Hospital of Henan University of Science and Technology | N/A |
| Recruiting | MRI and CT Simulation in the Evaluation of Tumor Response and Target Volume Definition for Esophageal or Esoph NCT02988921 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | N/A |
| Terminated | Tumour and HEalthy Tissues DOse-response and Radiosensitivity Assay NCT02797405 | Centre Leon Berard | N/A |
| Completed | Phase II/III Study Comparing Chemoradiotherapy With Radiotherapy in Elderly Patients With Esophageal or Esopha NCT02979691 | Chinese Academy of Medical Sciences | Phase 2 / Phase 3 |
| Withdrawn | Study of Inspiratory Muscle Training for Patients Undergoing Esophageal Surgery NCT02843750 | Mayo Clinic | N/A |
| Completed | Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors NCT02552121 | Seagen Inc. | Phase 1 / Phase 2 |
| Recruiting | Mayo Clinic Upper Digestive Disease Survey NCT02530983 | Mayo Clinic | — |
| Unknown | WEI NASAL JET for The Sedation of Outpatient Upper Gastrointestinal Endoscopy NCT02436018 | RenJi Hospital | N/A |
| Terminated | Effects of S-1 and Capecitabine on Coronary Artery Blood Flow NCT02216149 | Heikki Joensuu | Phase 2 |
| Unknown | DC Vaccine Combined With CIK Cells in Patients With Esophagus Cancer NCT02693236 | Affiliated Hospital to Academy of Military Medical Sciences | Phase 1 / Phase 2 |
| Unknown | Adverse Events During Upper Gastrointestinal Endoscopy NCT01979549 | RenJi Hospital | — |
| Completed | Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors NCT02001623 | Seagen Inc. | Phase 1 / Phase 2 |
| Recruiting | Proton Therapy for Esophageal Cancer NCT01684904 | Loma Linda University | N/A |
| Terminated | A Study of MM-111 and Paclitaxel With Trastuzumab in Patients HER2 Positive Carcinomas of the Distal Esophagus NCT01774851 | Merrimack Pharmaceuticals | Phase 2 |
| Completed | Imaging Study Compare 4DCT Image NCT01626001 | M.D. Anderson Cancer Center | Phase 1 |
| Completed | The Effect of Parenteral Nutrition Supplement on Esophagectomy Patients NCT01669356 | Shanghai Zhongshan Hospital | N/A |
| Completed | Radiochemotherapy in Elderly Patients With Oesophagus Cancer NCT02879227 | Centre Hospitalier Universitaire de Besancon | Phase 2 |
| Completed | Venous Thromboembolism and Haemostatic Disturbances in Patients With Upper Gastrointestinal Cancer NCT00660205 | University of Aarhus | — |
| Completed | IMRT Tomotherapy for Esophagus Cancer NCT00593723 | Washington University School of Medicine | Phase 1 |
| Completed | Preoperative Therapy With Oxaliplatin/Docetaxel/Capecitabine and Radiation in Resectable Esophagus Cancer NCT00193128 | SCRI Development Innovations, LLC | Phase 1 / Phase 2 |
| Completed | Advanced Oesophageal Cancer Study to Compare Quality of Life and Palliation of Dysphagia. NCT00193882 | Trans Tasman Radiation Oncology Group | Phase 3 |
| Recruiting | Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer NCT04821778 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 3 |
| Completed | Irinotecan and Taxotere With Radiotherapy as Preoperative Treatment in Resectable Esophageal Cancer NCT00318903 | University of Alabama at Birmingham | Phase 2 |
| Completed | Sequentially Administered CPT-11 and Mitomycin C in Patients With Advanced Esophageal and Stomach Cancer NCT00201747 | Ohio State University Comprehensive Cancer Center | Phase 2 |
| Completed | Chemotherapy With or Without Surgical Resection in Locally Advanced Esophageal Cancer NCT00193141 | SCRI Development Innovations, LLC | Phase 2 |
| Completed | The Effect of Epoetin Alfa on the Anemia of Patients With Selected Cancers Receiving Chemotherapy NCT00270166 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |