| Not Yet Recruiting | Overnight TI in TLE NCT07434986 | Duke University | N/A |
| Not Yet Recruiting | A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome NCT07013331 | Hospices Civils de Lyon | N/A |
| Not Yet Recruiting | Biomarkers of Response to SEEG Thermocoagulation NCT07399327 | Assistance Publique Hopitaux De Marseille | N/A |
| Not Yet Recruiting | Evaluation of the Efficacy of Neurofeedback Technique Based on EEG Desynchronization in Epileptic Patients NCT07356661 | Assistance Publique Hopitaux De Marseille | N/A |
| Not Yet Recruiting | MRgFUS for Childhood Epilepsy NCT07497178 | The Hospital for Sick Children | N/A |
| Not Yet Recruiting | Outcomes of Drug Resistant Epileptic Pediatric Patient by Modified Atkins Diet NCT07275125 | Sohag University | — |
| Recruiting | Infrared Photobiomodulation in Humans With Epilepsy NCT07145489 | Beth Israel Deaconess Medical Center | N/A |
| Not Yet Recruiting | CANnabinoids for Drug Resistant Epilepsy (DRE) in Adults and Children NCT07023744 | University of Manitoba | Phase 2 |
| Active Not Recruiting | Safety, Tolerability, and Pharmacokinetics (PK) of Single and Multiple Ascending Oral Doses of iQ-007 NCT06899230 | iQure Australia Pty Ltd | Phase 1 |
| Not Yet Recruiting | Long Term Efficacy and Safety of TMS Targeting Cerebellum to Treat DRE NCT06832813 | Xijing Hospital | N/A |
| Recruiting | Cartography of Social Cognition Network and Their Alterations in Patients With Epilepsy NCT05527093 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Efficacy of Personnalized Transcranial Direct Current Electrical Stimulation (tDCS) in Drug-resistant Epilepti NCT06334952 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Efficacy of Low Glycemic Index Diet Versus Classic Ketogenic Diet in Pediatric Epilepsy Treatment NCT06703983 | Mashhad University of Medical Sciences | N/A |
| Recruiting | Temporal Interference for Drug Resistant Epilepsy NCT06708143 | Xuanwu Hospital, Beijing | N/A |
| Not Yet Recruiting | Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients NCT06665880 | Xuanwu Hospital, Beijing | — |
| Recruiting | Evaluating Modulation Effects of Temporal Interference Using SEEG NCT06663969 | Xuanwu Hospital, Beijing | N/A |
| Recruiting | A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patien NCT06388707 | NaviFUS Corporation | Phase 1 / Phase 2 |
| Recruiting | A Pilot Study to Evaluate the Efficacy and Safety of NaviFUS™ System Neuromodulating Treatment for Patients Wi NCT06492720 | NaviFUS Corporation | N/A |
| Not Yet Recruiting | Lentiviral Gene Therapy for Epilepsy NCT04601974 | University College, London | Phase 1 / Phase 2 |
| Recruiting | MiCrobiota-gut-brain Axis in Resistant Epilepsy NCT07010445 | Niguarda Hospital | N/A |
| Active Not Recruiting | A First in hUman Study for Resistant Epilepsy With the Vagus Nerve stimulatiOn Device by syneRgia medicAl NCT06340802 | Synergia Medical | N/A |
| Recruiting | Exploring the Characteristics of Epileptogenic Foci in Drug-Resistant Epilepsy Based on Multimodal Imaging Tec NCT06557720 | Xijing Hospital | — |
| Recruiting | StereoEEG Motor Neuronal Potentials Decoding NCT06432907 | Research Center of Neurology, Russia | N/A |
| Not Yet Recruiting | Assessment of Patients With Drug-resistant Temporal Lobe Epilepsy With EEG Extended With Intra-auricular Elect NCT06366009 | Przemyslaw Kunert | — |
| Not Yet Recruiting | Leucine Enriched Essential Amino Acid Powder as an Add-on to a Classic Ketogenic Diet in Refractory Epilepsy NCT06387186 | Elizabeth Anne Thiele | Phase 1 |
| Enrolling By Invitation | Real-World Study of Magnetic Resonance-guided Laser Interstitial Thermal Therapy for Drug-resistant Epilepsy NCT06341075 | Beijing Tiantan Hospital | N/A |
| Unknown | The Role of Vitamin D in Neuroinflammatory on Drug Resistant Epilepsy NCT06053281 | DINA KEUMALA SARI | EARLY_Phase 1 |
| Recruiting | Management of Drug-resistant Epilepsy in Infants and Children: a Real-life Study of the Use of the Ketogenic D NCT06075485 | Nutricia Nutrition Clinique | — |
| Recruiting | Investigating Surprise Signals in the Anterior Insula NCT05997758 | University Hospital, Geneva | — |
| Recruiting | Focused Ultrasound for Drug-resistant Epilepsy NCT06292494 | Taipei Veterans General Hospital, Taiwan | N/A |
| Recruiting | Epileptogenic Network Visualisation With Advanced MRI NCT06059157 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Recruiting | Evaluation of the NaviFUS System in Drug Resistant Epilepsy NCT05947656 | Genovate-NaviFUS (Australia) Pty Ltd. | N/A |
| Recruiting | Goals for Epilepsy Clinic Visits Trial NCT05928598 | University of Michigan | N/A |
| Unknown | Cathodal Transcranial Direct Current Stimulation in Patients With Drug-resistant Focal Epilepsy NCT05951244 | Koç University | N/A |
| Completed | The Mechanism of cTBS Targeting Dentate Nucleus for DRE NCT05809349 | Xijing Hospital | N/A |
| Unknown | The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children NCT05697614 | Dr Cipto Mangunkusumo General Hospital | Phase 4 |
| Recruiting | Exogenous Ketone Esters for Drug Resistant Epilepsy NCT05670847 | Sohag University | Phase 2 / Phase 3 |
| Recruiting | Neurosurgical Outcome Network NCT06724029 | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | — |
| Unknown | MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy NCT05555537 | Assiut University | — |
| Recruiting | Electroclinical Correlation of Anxiety NCT05393518 | University Hospital, Bordeaux | N/A |
| Completed | Clinical Study Evaluating the Safety of Lactobacillus Probiotic in Children With Drug Resistant Epilepsy NCT05539287 | Tanta University | Phase 2 |
| Completed | the Safety and Efficacy of N-acetyl Cysteine in Children With Drug-Resistant Epilepsy NCT05485558 | Tanta University | Phase 2 |
| Completed | Effects of Low Glycemic Index Diet in Children With Drug-resistant Epilepsy NCT06432231 | Izmir Katip Celebi University | N/A |
| Recruiting | The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy NCT05019885 | Madeline Fields | Phase 2 |
| Completed | Electrophysiologic Studies of Cognition in Epilepsy Patients NCT05769634 | Icahn School of Medicine at Mount Sinai | N/A |
| Recruiting | Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain. NCT05459090 | Neuromed IRCCS | — |
| Recruiting | Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients NCT06309251 | Danone Nutricia SpA Società Benefit | — |
| Recruiting | A Neuro-cognitive and Psychosocial Intervention Module in People With Epilepsy NCT06537986 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Not Yet Recruiting | PRediction of Vagal Nerve Stimulation EfficaCy In Drug-reSistant Epilepsy NCT04935567 | Masaryk University | N/A |
| Terminated | RNS System RESPONSE Study NCT04839601 | NeuroPace | N/A |
| Completed | NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy NCT04999046 | NaviFUS Corporation | N/A |
| Unknown | Role of the Gut Microbiota in Pediatric Epilepsy NCT04705298 | British Columbia Children's Hospital | Phase 4 |
| Unknown | Efficacy, Safety and Pharmacokinetics of ES-481 in Adult Patients With Drug Resistant Epilepsy NCT04714996 | ES Therapeutics Australia Pty Ltd | Phase 2 |
| Terminated | A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With NCT04378075 | PTC Therapeutics | Phase 2 / Phase 3 |
| Unknown | Cortical Resections in Drug Resistant Epilepsy NCT04553354 | Assiut University | — |
| Unknown | Ketonemia Through Menstrual Cycle NCT05234411 | University of Pavia | — |
| Recruiting | Impact of Mindfulness Intervention on Quality of Life in Patients With Drug-resistant Epilepsy. NCT04126369 | University Hospital, Grenoble | N/A |
| Completed | The GABAergic Inhibitory System in Drug Resistant Epilepsy NCT06789497 | University of Coimbra | N/A |
| Recruiting | MEG Versus EEG HR for the Localization of the Epileptogenic Zone as Part of the Pre-surgical Assessment of Epi NCT03893916 | Hospices Civils de Lyon | N/A |
| Completed | Safety of Using NaviFUS System in Patients With Drug Resistant Epilepsy NCT03860298 | NaviFUS Corporation | N/A |
| Completed | Feasibility, Tolerability and Efficacy of the Ketogenic Diet in Children With Drug-resistant Epilepsy in South NCT05697887 | Number 2 Children's Hospital, Ho Chi Minh City | N/A |
| Terminated | A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects W NCT03739840 | UCB Biopharma SRL | Phase 3 |
| Recruiting | Low Intensity Focused Ultrasound Epilepsy: A Pilot Trial NCT03868293 | Brigham and Women's Hospital | N/A |
| Terminated | Cannabis Extract in Refractory Epilepsy Study NCT03808935 | The Epilepsy Research Program of the Ontario Brain Institute | Phase 3 |
| Unknown | Comparison of Efficacy of LGIT and MAD Among Children With Drug Resistant Epilepsy NCT03764956 | All India Institute of Medical Sciences | Phase 4 |
| Terminated | Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult S NCT03370120 | UCB Biopharma SRL | Phase 2 |
| Completed | Vitamine D in Drug Resistant Epilepsy NCT03475225 | Centre Hospitalier St Anne | Phase 3 |
| Completed | Circulating microRNAs as Biomarkers of RESPIratory Dysfunction in Patients With Refractory epilePSY NCT03419000 | Hospices Civils de Lyon | N/A |
| Unknown | Comparison Between Efficacy of Daily and Intermittent Low Glycemic Index Therapy Diet NCT03464487 | All India Institute of Medical Sciences | N/A |
| Completed | Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults NCT03373383 | UCB Biopharma S.P.R.L. | Phase 2 |
| Completed | Registry of Subjects With Drug Resistant Epilepsy and Treated With the VNS Therapy System. NCT03529045 | LivaNova | — |
| Recruiting | Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain NCT03268824 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Completed | Novel Helmet Design in Patients With Seizures NCT03443388 | Michael A. Gelfand, MD, PhD | N/A |
| Completed | Effect of Magnesium Supplementation for Children With Drug Resistant Idiopathic Epilepsy NCT02982824 | Ain Shams University | N/A |
| Unknown | Dietary Therapy In Epilepsy Treatment (DIET-Trial): A Randomised Non Inferiority Trial Comparing KD, MAD & LGI NCT02708030 | All India Institute of Medical Sciences | N/A |
| Available | Cannabidiol for Drug Resistant Pediatric Epilepsy (Expanded Access Use) NCT03676049 | John | — |
| Available | Extended Access Program With Lorcaserin For The Treatment of Dravet Syndrome and Other Refractory Epilepsies NCT04457687 | Eisai Inc. | — |
| No Longer Available | Study of Cannabidiol for Drug-Resistant Epilepsies NCT03014440 | Eric Marsh, MD | — |