| Not Yet Recruiting | Evaluation of Oral THC and CBD in Men and Women NCT05067387 | University of California, Los Angeles | Phase 1 |
| Not Yet Recruiting | Team-based Learning Intervention to Prevent Risk Factors for Chronic Diseases - a Cluster Randomized Trial NCT06894134 | Professor Fernando Figueira Integral Medicine Institute | N/A |
| Not Yet Recruiting | HARM REDUCTION INTERVENTION FOR PEOPLE WHO USE ANABOLIC ANDROGENIC STEROIDS: THE RANDOMIZED CONTROLLED TRIAL NCT07039539 | University of Sao Paulo | N/A |
| Completed | Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnan NCT06262347 | T. John Winhusen, PhD | N/A |
| Active Not Recruiting | OUD Smartphone Services NCT06134882 | Western Michigan University | N/A |
| Completed | An Evaluation of Healthcare Providers' Adherence to Pharmacovigilance Practices in an African Community NCT06428162 | Deraya University | — |
| Completed | Satir Model for Self-esteem, Mental Health, and Family Function Among Individuals With Substance Use Disorders NCT06044363 | Hong Kong Metropolitan University | N/A |
| Recruiting | Peer-led Personalized Support Program NCT05918601 | Chinese University of Hong Kong | N/A |
| Recruiting | Wakaya: Rising Up for Choctaw Youth Health NCT05818384 | University of Washington | N/A |
| Recruiting | AA on Drug Abusers by Nursing Students NCT05877742 | The Hong Kong Polytechnic University | N/A |
| Completed | An Explorative Pilot Study of a New Mobile Phone Application Measuring Eye Parameters of Eyes in Patients With NCT05737550 | Kontigo Care AB | N/A |
| Completed | A First Study in Healthy Volunteers of a New Mobile Phone Application Measuring the Eyes Before and After Medi NCT05731999 | Kontigo Care AB | N/A |
| Unknown | Effect of Folic Acid on the Presentation of Nuclear Abnormalities in People With a History Drug Abuse NCT05712044 | Centro Universitario de Tonalá | N/A |
| Completed | Evaluation of Smoked THC and CBD in Men and Women NCT05037487 | University of California, Los Angeles | Phase 1 |
| Unknown | ASSIST: A Surveillance Study of Illicit Substance Toxicity NCT05329142 | NHS Greater Glasgow and Clyde | — |
| Not Yet Recruiting | Neurobiological Effects of Transcranial Direct Current Stimulation Treatment in Alcohol Use Disorder NCT04897295 | ITAB - Institute for Advanced Biomedical Technologies | N/A |
| Completed | Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-stud NCT03911739 | T. John Winhusen, PhD | — |
| Unknown | Addiction in Intensive Cardiac Care Units NCT05063097 | Assistance Publique - Hôpitaux de Paris | — |
| Unknown | Peer-delivered Brief Motivational Interviewing Via Instant Messaging Interaction in Reducing the Drug Abuse Am NCT04672746 | The University of Hong Kong | N/A |
| Active Not Recruiting | Factors Predicting Outcome in Group Treatment of Alcohol Use Disorders (AUDs) NCT04822987 | The Hospital of Vestfold | — |
| Completed | Delivering Contingency Management in Outpatient Addiction Treatment NCT04544124 | University of Calgary | N/A |
| Completed | Peer-delivered Follow-up Text Communication After a Brief Motivational Interviewing (MI) for Adolescent Drug A NCT04634968 | The University of Hong Kong | N/A |
| Unknown | Hotline Service for Drug-abusing Youth and Young Adults NCT04461314 | The University of Hong Kong | N/A |
| Completed | Medication Treatment for Opioid Use Disorder in Expectant Mothers NCT03918850 | T. John Winhusen, PhD | Phase 3 |
| Completed | Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study NCT03911466 | T. John Winhusen, PhD | — |
| Completed | Hospitalisations of Teenagers and Young Adulthoods in Mayotte After Consumption of an Illegal Drug Called " Ch NCT04547751 | University Hospital, Bordeaux | — |
| Completed | Isolated During COVID-19: Effects of COVID-19's Social Restrictions on Loneliness and Psychosocial Symptomatol NCT04440098 | University of Miami | — |
| Completed | Nitrous Oxyde Misuse Among Teenagers Consulting in an Addictology Center Dedicated to Young Drug Users in Mont NCT04301024 | University Hospital, Montpellier | — |
| Recruiting | Structured Physical Exercise in Short-term Inpatient Treatment of Substance Use Disorder NCT04141202 | St. Olavs Hospital | — |
| Completed | Westlake Personalized Nutrition and Health Cohort for Drug Addicts NCT04105621 | Westlake University | — |
| Withdrawn | A Community-University Approach to Preventing HIV NCT03938077 | University of Michigan | N/A |
| Completed | A Family-based Intervention for Drug-abusing Adults in Hong Kong NCT04725266 | The University of Hong Kong | N/A |
| Unknown | Population Screening Using Smartphone in Milpa Alta NCT04067063 | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | — |
| Unknown | Massive Mental Health Screening Using Smartphones in 24 Pre-graduate Education Centers in Mexico City: TEDUCA NCT04067076 | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | — |
| Completed | Leveraging Implementation Science to Increase Access to Trauma Treatment for Incarcerated Drug Users NCT04007666 | University of Arkansas | N/A |
| Completed | Ketamine IV Classic Protocol : Five Years Follow up NCT04824157 | Sheba Medical Center | — |
| Unknown | Motivational Strategies in Batterer Intervention Programs for Offenders With Alcohol/Drug Abuse Problems (IMP- NCT03885349 | University of Valencia | N/A |
| Completed | CBT4CBT for Women in Residential Treatment for Substance Use Disorders NCT03678051 | Virginia Commonwealth University | N/A |
| Completed | Drug Abuse Among Elective Surgeries: an Observational Study. NCT05123521 | Cairo University | — |
| Completed | Naloxone Nasal Spray Compared With Naloxone Injection for Opioid Overdoses Outside the Hospital NCT03518021 | Norwegian University of Science and Technology | Phase 3 |
| Completed | Preventing HIV/STI in Urban Adolescents Via an mHealth Primary Care Intervention NCT03368456 | University of Michigan | N/A |
| Completed | Arsha Vidya Program for Preventing Drug Abuse Among Disadvantaged Children in Urban Slums NCT03472222 | NMP Medical Research Institute | N/A |
| Completed | A Prospective Investigation of the Risks of Opioid Misuse, Abuse, and Addiction Among Patients Treated With Op NCT02751762 | Member Companies of the Opioid PMR Consortium | — |
| Completed | Determination the Abuse Potential of Pitolisant in Healthy, Non-Dependent Recreational Stimulant Users NCT03152123 | Bioprojet | Phase 1 |
| Unknown | Double Blind Placebo Control Opipramol-Baclofen Treatment for Addiction NCT03065998 | Ministry of Health, Israel | EARLY_Phase 1 |
| Completed | A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses NCT02922959 | University of Cincinnati | N/A |
| Unknown | 90-Day Online Substance Use Program NCT03069118 | Workit Health | N/A |
| Terminated | Discontinuation vs Continuation of Long-term Opioid Therapy in Suboptimal and Optimal Responders With Chronic NCT02741076 | Member Companies of the Opioid PMR Consortium | Phase 4 |
| Completed | Testing a Multilevel Preventive Intervention in Youth Courts NCT02764099 | National Health Promotion Associates, Inc. | N/A |
| Completed | Crossover Study to Evaluate the Abuse Potential of Intranasal Esketamine Compared to Racemic Intravenous Ketam NCT02682225 | Janssen Research & Development, LLC | Phase 1 |
| Completed | A Study to Evaluate Abuse Potential of Istradefylline NCT02609477 | Kyowa Kirin Co., Ltd. | Phase 1 |
| Recruiting | Suicidal Behavior in Patients Diagnosed With Bipolar Disorder NCT02604277 | Emory University | N/A |
| Completed | Validation of PRISM-5-Op, Measure Of Addiction To Prescription Opioid Medication NCT02660619 | Member Companies of the Opioid PMR Consortium | — |
| Completed | Enhancing Housing First Programs With a Social Network Substance Use Intervention NCT02140359 | RAND | N/A |
| Completed | An Observational Study to Develop Algorithms for Identifying Opioid Abuse and Addiction Based on Admin Claims NCT02667262 | Member Companies of the Opioid PMR Consortium | — |
| Completed | Study to Validate Coded Medical Terms Used to Identify Opioid-Related Overdose in Databases Used for PMR Study NCT02667197 | Member Companies of the Opioid PMR Consortium | — |
| Completed | A Quantitative Study to Assess the Construct Validity of the Prescription Opioid Misuse and Abuse Questionnair NCT02678507 | Member Companies of the Opioid PMR Consortium | — |
| Completed | Cross-Sectional Study to Define and Validate "Doctor/Pharmacy Shopping" as Outcomes Suggestive of Abuse and/or NCT02668549 | Member Companies of the Opioid PMR Consortium | — |
| Completed | A Qualitative Study to Assess the Content Validity of the Prescription Opioid Misuse and Abuse Questionnaire NCT02660606 | Member Companies of the Opioid PMR Consortium | — |
| Completed | Implementing Screening for Cannabis and Other Drug Use Disorders in Primary Care: Impact on Diagnosis and Trea NCT06249542 | Kaiser Permanente | N/A |
| Completed | A Survey to Eval the Relation Between Doctor/Pharmacy Shopping and Outcomes Suggestive of Misuse, Abuse and/or NCT02667158 | Member Companies of the Opioid PMR Consortium | — |
| Completed | Study to Eval Relation Btw Doctor/Pharmacy Shopping & Outcomes of Misuse, Diversion, Abuse, Addiction by Med R NCT02667210 | Member Companies of the Opioid PMR Consortium | — |
| Completed | Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks NCT02224508 | Kaiser Permanente | — |
| Completed | Phone Interview to Prevent Recurring Opioid Overdoses NCT02282306 | University of Cincinnati | N/A |
| Completed | A Pilot, Proof-of-concept Cohort Study of the Prevalence of Comorbid Mental Illness and Substance Abuse NCT02476877 | Advanced Clinical Laboratory Solutions, Inc. | — |
| Withdrawn | Trial of Computerized MET for Adolescent Substance Use NCT01784653 | Boston Children's Hospital | Phase 1 |
| Completed | Computerized Brief Intervention vs. Delayed Computerized Brief Intervention NCT01936623 | Friends Research Institute, Inc. | N/A |
| Withdrawn | Reducing Problematic Substance Use in Youth With Chronic Medical Conditions NCT01709201 | Boston Children's Hospital | N/A |
| Completed | A Web App for Patients With Alcohol and Drug Use Problems in Primary Care NCT01830114 | Behavior Therapy Associates, LLP | N/A |
| Withdrawn | The Therapeutic Workplace Intervention in Community Settings NCT01841892 | University of Maryland, Baltimore County | N/A |
| Completed | Brief Intervention for Rural Women at High Risk for HIV/HCV NCT01840722 | Michele Staton | N/A |
| Completed | Preventing Drug Abuse Among Hispanic Adolescents NCT02375516 | Columbia University | N/A |
| Completed | Multi-court Trial of NBP to Prevent Substance Abuse and Mental Health Disorders (MTC) NCT06132971 | Arizona State University | N/A |
| Completed | Indirect Assessment and Intervention for Perinatal Drug Use NCT01650675 | Wayne State University | Phase 2 |
| Completed | A Study to Assess the Abuse Potential of Hydrocodone Extended-Release Tablet in Recreational Opioid Users NCT01596673 | Cephalon | Phase 1 |
| Unknown | Prevention and Reduction of Alcohol and Drug Problems in a Clinical Psychiatric Youth Population NCT01595568 | St. Justine's Hospital | N/A |
| Withdrawn | Study in Healthy Recreational Polydrug Users to Measure the Abuse Potential of TC-5214 NCT01500018 | AstraZeneca | Phase 1 |
| Completed | Development and Testing of Adolescent Twelve-Step Facilitation NCT01449981 | Massachusetts General Hospital | N/A |
| Completed | Family-Skills Training to Prevent Tobacco and Other Substance Use in Latino Youth NCT01442753 | University of Minnesota | N/A |
| Withdrawn | cSBIRT to Reduce Teen Tobacco, Alcohol and Drug Use NCT01275391 | Boston Children's Hospital | Phase 1 / Phase 2 |
| Completed | Impact of Online Patient Feedback (OQ) to Therapist NCT01891045 | Oslo University Hospital | N/A |
| Completed | Multimedia Toolkits to Implement 12-Step Recovery Concepts in Group Counseling NCT02333357 | Treatment Research Institute | N/A |
| Completed | Healthier You: Optimizing Screening, Brief Interventions, and Referral to Treatment (SBIRT) in the Emergency D NCT01113190 | University of Michigan | N/A |
| Completed | Screening, Motivational Assessment, Referral, and Treatment in Emergency Departments NCT01207791 | University of New Mexico | N/A |
| Completed | Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use NCT00907309 | Boston Children's Hospital | Phase 1 / Phase 2 |
| Completed | Screening Brief Intervention Referral to Treatment (SBIRT) in New Mexico NCT01131520 | Friends Research Institute, Inc. | N/A |
| Completed | Dynamic Assessment and Referral System - Evaluation NCT01153373 | University of Massachusetts, Worcester | Phase 2 |
| Completed | The Effects of Expectation on Natural and Drug -Induced Rewards NCT01036230 | National Institute on Drug Abuse (NIDA) | — |
| Completed | Screening, Brief Intervention, and Referral to Treatment for Drug Use NCT01683227 | San Diego State University | N/A |
| Completed | Oral Fluid, Plasma and Whole Pharmacokinetics and Stability Following Smoked Cannabis NCT01071616 | National Institute on Drug Abuse (NIDA) | Phase 1 |
| Completed | Multidisciplinary Approach to Reduce Injury and Substance Abuse NCT01048359 | University of Texas at Austin | Phase 3 |
| Withdrawn | Multiple Behavior Screening, Brief Intervention and Referral to Treatment (SBIRT) Model of Drug Abuse in Prima NCT01439334 | University of Florida | N/A |
| Completed | Prenatal Drug Exposure: Effects on the Adolescent Brain and Behavior Development NCT01020669 | National Institute on Drug Abuse (NIDA) | — |
| Terminated | Brain Glutamate Receptors and Cocaine Dependence NCT00951314 | National Institute on Drug Abuse (NIDA) | — |
| Completed | Developing Field Tools for Real-Time Assessment of Exposure to Psychosocial Stress and Drug Use in an Outpatie NCT00787423 | National Institute on Drug Abuse (NIDA) | — |
| Completed | Behavioral Couples Therapy for Female Drug-Abusing Patients NCT01189305 | Harvard University | Phase 2 |
| Completed | Prevention of Post Sexual Assault Stress NCT01430624 | Medical University of South Carolina | Phase 1 / Phase 2 |
| Completed | Assessing Screening Plus Brief Intervention's Resulting Efficacy (ASPIRE) to Stop Drug Use NCT00876941 | Boston Medical Center | Phase 3 |
| Completed | Abuse Potential of Single Doses of Lorcaserin in Healthy Recreational Polydrug Users NCT00828659 | Eisai Inc. | Phase 1 |
| Completed | Effects of Levetiracetam (Keppra) on Alcohol Consumption NCT01168687 | University of California, San Francisco | N/A |
| Completed | Disulfiram Interactions With HIV Medications: Clinical Implications NCT00878306 | University of California, San Francisco | Phase 1 |
| Completed | Alcohol, Suicide and HIV Prevention for Teens in Mental Health Treatment NCT02228044 | George Mason University | N/A |
| Completed | Acceptability and Safety of Switching From Subutex or Other Opioid Drug Dependence Therapy to Suboxone (NIS P0 NCT00725608 | Indivior Inc. | — |
| Completed | Contingency Management of Psychostimulant Abuse in the Severely Mentally Ill NCT00809770 | University of Washington | N/A |
| Completed | Treatment of Opioid Dependent Patients With Suboxone: Acceptability & Safety Data From Real Life Scenario (Stu NCT00723749 | Indivior Inc. | — |
| Completed | Quetiapine for the Reduction of Cocaine Use NCT00631748 | Seattle Institute for Biomedical and Clinical Research | N/A |
| Completed | Pharmacological, Clinical and Statistical Assessment of a New Tool Available for Pharmacodependence Report Eva NCT01052675 | Nantes University Hospital | — |
| Completed | Stimulant Abuser Groups to Engage in 12-Step NCT00573183 | University of Washington | Phase 3 |
| Withdrawn | Brief Integrative Alcohol Interventions for Adolescents NCT01427465 | University of Florida | N/A |
| Completed | Preference for Subutex® (Buprenorphine) Versus Suboxone® (Buprenorphine/Naloxone) in Opioid Dependent Patients NCT00684073 | Indivior Inc. | Phase 4 |
| Completed | Observational Study of Misuse of High Dose Buprenorphine (Subutex® or Generic) in Opiate-Addicted Patients in NCT00723697 | Indivior Inc. | — |
| Completed | Adventure: Teacher Delivered Personality-targeted Interventions for Substance Misuse NCT00776685 | King's College London | Phase 2 / Phase 3 |
| Completed | Clinical Studies on the Therapeutic Effects of Mirtazapine on Drug-craving in Cocaine Addicts. NCT01949571 | Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente | Phase 2 |
| Completed | Fetal Neurobehavior in Non-methadone Maintained Women in Substance Abuse Treatment NCT00522626 | Johns Hopkins University | — |
| Completed | Prometa Pharmacotherapy for Methamphetamine Dependence NCT00260481 | University of California, Los Angeles | Phase 2 / Phase 3 |
| Completed | Project Health Link: Connecting Patients With Services NCT00251173 | University of Michigan | N/A |
| Completed | Effect of Functional Genetic Polymorphisms on Brain Morphology and Function NCT01035723 | National Institute on Drug Abuse (NIDA) | — |
| Completed | Brief Intervention for Drug Abusing Adolescents NCT00350909 | University of Minnesota | Phase 2 |
| Completed | Integration of Buprenorphine Into HIV Clinical Settings - Primary Care Model (PCM) NCT00798538 | Yale University | Phase 4 |
| Completed | Cognitive Task Development and Implementation for Functional MRI Studies NCT01036685 | National Institute on Drug Abuse (NIDA) | — |
| Completed | Adolescent Family-Based Alcohol Prevention NCT00858065 | Pacific Institute for Research and Evaluation | N/A |
| Completed | Reward Processing in Cocaine Addiction NCT01036074 | National Institute on Drug Abuse (NIDA) | — |
| Completed | Youth Drug Abuse Family and Cognitive-Behavioral Therapy NCT00198874 | University of Florida | Phase 2 |
| Completed | Brief Youth Substance Use Intervention for Primary Care NCT00292240 | RAND | N/A |
| Terminated | Behavioral Therapy Development for Methamphetamine Abuse NCT00252434 | University of California, Los Angeles | Phase 1 |
| Completed | Prevention Program for Problem Behaviors in Girls in Foster Care NCT00239837 | Oregon Social Learning Center | N/A |
| Completed | Personality-targeted Interventions for Adolescent Alcohol Misuse NCT00344474 | King's College London | Phase 2 / Phase 3 |
| Recruiting | Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging NCT01036581 | National Institute on Drug Abuse (NIDA) | N/A |
| Completed | Improving Hepatitis C Treatment in Injection Drug Users NCT00148031 | State University of New York - Upstate Medical University | Phase 4 |
| Completed | Behavioral and Subjective Efficacy of Ramelteon in Subjects With a History of Polydrug Abuse NCT00671632 | Takeda | Phase 2 |
| Completed | Effects of Nicotine on Cognitive Task Performance and Brain Activity as Measured by fMRI NCT01036711 | National Institute on Drug Abuse (NIDA) | — |
| Completed | Self-Selected Brief Alcohol Intervention for Adolescents NCT00383838 | RAND | N/A |
| Completed | Effects of Nicotine on Brain Activity as Measured by fMRI NCT01037153 | National Institute on Drug Abuse (NIDA) | — |
| Completed | Reinforcement-Based Treatment and Abstinence-Contingent Housing for Drug Abusers NCT00685620 | National Institute on Drug Abuse (NIDA) | Phase 4 |
| Completed | Neurobehavioral Model of HIV in Injection Drug Users NCT00198861 | The City College of New York | — |
| Completed | Cognitive Behavioral Stress Management for HIV+ Drug Abusers NCT00722644 | National Institute on Drug Abuse (NIDA) | Phase 1 |
| Completed | Student Athlete Testing Using Random Notification NCT00451854 | National Institute on Drug Abuse (NIDA) | N/A |
| Completed | PET Assays of Striatal Dopamine Marker in Cocaine Craving NCT01036516 | National Institute on Drug Abuse (NIDA) | — |
| Completed | Acute Intervention to Reduce Distress Following Sexual Assault NCT01622855 | Medical University of South Carolina | Phase 1 / Phase 2 |
| Unknown | ER/LA Opioid Analgesics - Surveillance Monitoring of State Medical Examiner Databases NCT02897414 | ER/LA Opioid REMS Program Companies (RPC) | — |
| Unknown | Monitoring Patterns of Prescribing to Identify Changes in Access to ER/LA Opioid Analgesics NCT02920775 | ER/LA Opioid REMS Program Companies (RPC) | — |
| Unknown | Surveillance Monitoring of Opioid Abuse in Poison and Drug Treatment Centers NCT02871232 | ER/LA Opioid REMS Program Companies (RPC) | — |
| Unknown | Evaluation of Changes in Prescribing Behavior of ER/LA Opioid Prescribers NCT02920762 | ER/LA Opioid REMS Program Companies (RPC) | — |
| Unknown | Evaluation of Drug Utilization Patterns for Extended Release/Long Acting Opioids and Comparator Products NCT02925806 | ER/LA Opioid REMS Program Companies (RPC) | — |
| Unknown | ER/LA Opioid Surveillance for Emergency Department Visits and Hospitalizations for Overdose and Poisoning NCT02866266 | ER/LA Opioid REMS Program Companies (RPC) | — |