NCT05037487

Evaluation of Smoked THC and CBD in Men and Women

Evaluation of Smoked THC and CBD in Oral Fluid, Pharmacokinetics, and Subjective and Neurocognitive Effects in Men and Women

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 21 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of inhaled cannabis with varying amounts of delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD) and to evaluate detection of recently smoked THC in oral fluid.

Detailed description

This double-blind placebo controlled, within-subject study study will assess testing devices that can measure biochemical markers in oral fluid and neurocognitive-performance markers of recent cannabis use. Other pharmacodynamic effects of inhaled cannabis with CBD and THC will be determined and the pharmacokinetics of THC, CBD, and respective metabolites will be assessed in whole blood.

Conditions

• Drug Abuse
• Intoxication by Drug
• Impairment

Interventions

Type	Name	Description
DRUG	Placebo Cannabis	Smoked placebo cannabis
DRUG	20 mg CBD Cannabis	Smoked cannabis with CBD
DRUG	20 mg CBD + 20 mg THC Cannabis	Smoked cannabis with CBD and THC
DRUG	20 mg THC Cannabis	Smoked cannabis with THC

Timeline

• Start date: 2022-09-01
• Primary completion: 2025-01-07
• Completion: 2025-06-08
• First posted: 2021-09-08
• Last updated: 2026-03-20

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study