| Recruiting | Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation NCT06805253 | Petrovsky National Research Centre of Surgery | — |
| Recruiting | Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES NCT05408559 | Texas Tech University Health Sciences Center | Phase 1 / Phase 2 |
| Terminated | Parasympathetic Augmentation Via Respiratory Training for Patients With Systolic Heart Failure NCT05223751 | Lancaster General Hospital | N/A |
| Recruiting | Assessment of CCM in HF With Higher Ejection Fraction NCT05064709 | Impulse Dynamics | N/A |
| Unknown | Investigating Multimodally Endothelial Dysfunction in Ocular and Systemic Disease NCT06485128 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Completed | Effects of Postural Balance Exercises in Patients With Heart Failure NCT04937790 | Giresun University | N/A |
| Unknown | Diastolic dYsfunctioN AssessMent in critICally Ill Patients NCT04584203 | Humanitas Clinical and Research Center | — |
| Recruiting | Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure NCT04160000 | Electrophysiology Research Foundation | Phase 4 |
| Completed | 2 New Measurements Used to Describe the Filling Phase of the Left Ventricle (LV). NCT04154878 | AdventHealth | — |
| Completed | Personalized Pacing: A New Paradigm for Patients With Diastolic Dysfunction or Heart Failure With Preserved Ej NCT04721314 | University of Vermont | N/A |
| Recruiting | Purinergic Signaling and the Postmenopausal Heart NCT06015776 | Beth Israel Deaconess Medical Center | — |
| Completed | Cardiac Resynchronisation Therapy Versus Rate-responsive Pacing in Heart Failure With Preserved Ejection Fract NCT03338374 | Cardiff and Vale University Health Board | N/A |
| Completed | CMR Exercise Stress Testing in HFpEF NCT03260621 | University of Göttingen | N/A |
| Unknown | Pedometer-Based Walking Intervention in Patients With Chronic Heart Failure With Preserved Ejection Fraction NCT03041376 | Charles University, Czech Republic | N/A |
| Completed | ST2 for the Management of Heart Failure - STADE-HF NCT02963272 | University Hospital, Montpellier | N/A |
| Terminated | Positive Airway Pressure Therapy Study in Sleep Apnea and Diastolic Heart Failure NCT02254382 | ResMed | N/A |
| Completed | Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF NCT02589977 | Marvin W. Kronenberg, M.D. | Phase 4 |
| Unknown | Manipal Heart Failure Registry (MHFR) NCT03157219 | Manipal University | — |
| Completed | Non-invasive Evaluation of Myocardial Stiffness by Elastography NCT02537041 | French Cardiology Society | N/A |
| Unknown | CORolla® TAA for Heart Failure With Preserved Ejection Fraction (HFpEF) and Diastolic Dysfunction (DD) NCT02499601 | CorAssist Cadiovascular Ltd. | N/A |
| Completed | Pharmacokinetics, Pharmacodynamics, and Impact of Inorganic Nitrate on Exercise in HFpEF NCT02256345 | University of Pennsylvania | Phase 2 |
| Completed | Validation of New Non-Invasive Parameters of Diastolic Suction in the Left Ventricle NCT02315859 | Insel Gruppe AG, University Hospital Bern | — |
| Completed | High Intensity Interval Training Versus Moderate Continuous Training in Heart Failure With Preserved Ejection NCT02916225 | Hospital de Clinicas de Porto Alegre | N/A |
| Completed | A Study of a Technology-enabled Disease Management Program to Reduce Hospitalizations for Heart Failure NCT02084992 | Tufts Medical Center | N/A |
| Terminated | Improving Treatment Personalization of Pulmonary Hypertension Associated With Diastolic Heart Failure NCT02053246 | University of Florida | Phase 4 |
| Terminated | Mathematical Modeling to Determine Basic Muscle Properties in the Failing Heart NCT01778894 | University of Nebraska | — |
| Completed | Enhancement of Physical Activity in Elderly Patients With Diastolic Heart Failure by a Motivational Interventi NCT03402490 | University of Göttingen | N/A |
| Withdrawn | If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure NCT00757055 | St Vincent's University Hospital, Ireland | Phase 2 |
| Unknown | A Randomized Trial of Udenafil Therapy in Patients With Heart Failure With Preserved Ejection Fraction [ULTIMA NCT01599117 | Seoul National University Hospital | Phase 3 |
| Terminated | Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2) NCT01942395 | University of Michigan | N/A |
| Terminated | Denervation of the renAl sympathetIc nerveS in hearT Failure With nOrmal Lv Ejection Fraction NCT01583881 | UMC Utrecht | Phase 2 / Phase 3 |
| Completed | The Metabolic Road to Diastolic Heart Failure: Diastolic Heart Failure Study NCT02446327 | Central Hospital, Nancy, France | N/A |
| Completed | The Regulation of Pulmonary Vascular Resistance in Patients With Heart Failure NCT02275793 | University of Toledo Health Science Campus | — |
| Completed | Left Ventricular Torsional Hysteresis: A Global Parameter for Diastolic Function NCT01431027 | University of Alabama at Birmingham | — |
| Completed | High Intensity Interval Exercise in Diastolic Heart Failure NCT02147613 | Arizona State University | N/A |
| Completed | Physiological Effects of Grape Seed Extract in Diastolic Heart Failure NCT01185067 | University of Michigan | Phase 1 |
| Completed | Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patients With Diastolic Failing Heart NCT01944384 | National Taiwan University Hospital | Phase 4 |
| Unknown | Diastolic Heart Failure Management by Nifedipine NCT01157481 | Demand Investigators | N/A |
| Completed | Ranolazine in Diastolic Heart Failure NCT01163734 | Gilead Sciences | Phase 2 |
| Completed | Metoprolol XR in Heart Failure With Normal Ejection Fraction NCT03882710 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 2 |
| Completed | Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet in Diastolic Heart Failure NCT00939640 | University of Michigan | N/A |
| Completed | Perhexiline Therapy in Heart Failure With Preserved Ejection Fraction Syndrome NCT00839228 | University of Aberdeen | Phase 2 |
| Completed | Role of Exercise in Diastolic Heart Failure NCT01047631 | University of Michigan | N/A |
| Withdrawn | Aliskiren and Renin Inhibition in Diastolic Heart Failure NCT00773084 | Texas Tech University Health Sciences Center | N/A |
| Completed | Rheos® Diastolic Heart Failure Trial NCT00718939 | CVRx, Inc. | N/A |
| Completed | Classification of Heart Failure With Preserved Ejection Fraction NCT01030991 | Northwestern University | — |
| Completed | Pulsatile and Steady State Hemodynamics in Diastolic Heart Failure NCT00720525 | Klinikum Wels-Grieskirchen | — |
| Terminated | Beginning a Randomized Evaluation of the AGE Breaker Alagebrium in Diastolic Heart Failure (BREAK-DHF-I) NCT00662116 | Synvista Therapeutics, Inc | Phase 2 |
| Terminated | A Randomized Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Effects of Alagebrium on Ex NCT01913301 | Cardiovascular Clinical Sciences Inc | Phase 2 |
| Terminated | Effect of Ranolazine on Echocardiographic Indices of Diastolic Dysfunction NCT00574756 | University of California, San Diego | N/A |
| Completed | Psychosocial Patterns and Prognosis in Patients With Heart Failure NCT00709241 | Assistance Publique - Hôpitaux de Paris | — |
| Unknown | Markers of Oxidative Stress Diastolic Dysfunction NCT00846404 | Emory University | — |
| Completed | The Effect of Eplerenone and Atorvastatin on Markers of Collagen Turnover in Diastolic Heart Failure NCT00505336 | St Vincent's University Hospital, Ireland | N/A |
| Completed | A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure NCT00303498 | Pfizer | Phase 2 |
| Completed | Phosphodiesterase-5 (PDE5) Inhibition and Pulmonary Hypertension in Diastolic Heart Failure NCT01156636 | University of Milan | Phase 2 / Phase 3 |
| Terminated | Effects of Statin Therapy on Vascular Properties and Outcomes in Diastolic Heart Failure Patients NCT00585611 | University of Wisconsin, Madison | N/A |
| Completed | PIE II: Pharmacological Intervention in the Elderly II NCT00123955 | Wake Forest University | Phase 3 |
| Terminated | Use of Nesiritide in the Management of Acute Diastolic Heart Failure NCT00083772 | M.D. Anderson Cancer Center | Phase 4 |
| Terminated | Reversing Endothelial and Diastolic Dysfunction and Improving Collagen Turnover in Diastolic Heart Failure NCT00293150 | The Cleveland Clinic | Phase 4 |
| Completed | Study of Nesiritide in Diastolic Heart Failure. NCT00309868 | Massachusetts General Hospital | Phase 1 / Phase 2 |
| Unknown | Essential Hypotension and Allostasis Registry NCT02018497 | CES University | — |