Trials / Unknown
UnknownNCT06485128
Investigating Multimodally Endothelial Dysfunction in Ocular and Systemic Disease
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 1,000 (estimated)
- Sponsor
- Universitaire Ziekenhuizen KU Leuven · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
To explore the distribution of retinal vasculature parameters in patients with different subtypes of cardiovascular and ocular disease.
Detailed description
In this interventional cohort study, the investigators aim to evaluate retinal vascular function as assessed by optical coherence tomography angiography, fundus photography and dynamic vessel analysis in patients who share microvascular involvement of their pathology (e.g. chronic kidney disease, cardiac decompensation, neuronal small vessel disease and glaucoma) and age-matched healthy controls. Plasm and skin samples for comparative proteomics and transcriptomics are also taken.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Optical coherence tomography(-angiography) OCT(A) | OCTA is a non-invasive diagnostic tool capable of generating cross-sectional coupes of the retina and choroid. Novel algorithms allow to render a 3-dimensional model of the ocular microcirculation based merely on the motion contrast of the circulating blood. |
| DIAGNOSTIC_TEST | Fundus pictures | Visucam (Zeiss), Topcon NW8 fundus camera, NFC 600 (Crystalvue) |
| DIAGNOSTIC_TEST | DVA 3.0 | IMEDOS GmbH |
| DIAGNOSTIC_TEST | Hyperspectral retinal images | Ximea SNm4x4 hyperspectral snapshot camera |
| DIAGNOSTIC_TEST | SphygmoCor | Sphygmocor Excell |
| DIAGNOSTIC_TEST | Sphygmomanometer | For the measurement of the blood pressure. |
| DIAGNOSTIC_TEST | Blood sample | For both routine cardiovascular health biomarkers as well as genetic markers (DNA, mRNA, miRNA). |
| DIAGNOSTIC_TEST | Skin biopsy | Spatial proteomics and transcriptomics for endothelial function. |
| DIAGNOSTIC_TEST | Neuropsychological examination | Moca, Stroop color word test, concept shifting test, COWAT, (R)AVLT, Beck depression inventory, GDS |
Timeline
- Start date
- 2021-07-06
- Primary completion
- 2024-12-31
- Completion
- 2024-12-31
- First posted
- 2024-07-03
- Last updated
- 2024-07-03
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT06485128. Inclusion in this directory is not an endorsement.