Trials / Conditions / Depression - Major Depressive Disorder

Depression - Major Depressive Disorder

139 registered clinical trials studyying Depression - Major Depressive Disorder — 111 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Efficacy and Safety of Accelerated Intermittent Theta-burst Stimulation (a-iTBS) in Adolescents With Depressiv NCT07369713	First Affiliated Hospital of Chongqing Medical University	N/A
Not Yet Recruiting	Deaf CBT-TS to Reduce Suicide Risk NCT07279363	University of Rochester	N/A
Not Yet Recruiting	Sham-Controlled Rapid-Acting Neuromodulation for Depression NCT07487454	University of California, Davis	N/A
Not Yet Recruiting	Efficacy and Safety of a Theta Burst Stimulation Protocol of Repetitive Transcranial Magnetic Stimulation in T NCT07529574	Jung-Sun Lee	N/A
Not Yet Recruiting	Mindfulness-based Psilocybin Therapy for PTSD NCT07104916	Anthony P King	Phase 2
Not Yet Recruiting	Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Menta NCT07506070	The Royal Ottawa Mental Health Centre	N/A
Not Yet Recruiting	Using Integrated Care and Wearable Technology to Evaluate Outcomes of the Shields & Stripes Program for Vetera NCT07452900	Baylor University	—
Not Yet Recruiting	Effect of Mindfulness-based Psychoeducation in Depression NCT07484789	University of Gaziantep	N/A
Enrolling By Invitation	HIV-Mental Illness Stigma Reduction and Outcomes in Malawi NCT06951542	University of Pennsylvania	N/A
Not Yet Recruiting	Pharmacogenetic-Guided Antidepressant Treatment in Depression NCT07480486	Mohammed V University in Rabat	N/A
Not Yet Recruiting	An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to NCT07373470	University of Pittsburgh	N/A
Not Yet Recruiting	Enhancing Slow Wave Sleep in Depression NCT07143838	Wake Forest University Health Sciences	N/A
Not Yet Recruiting	Efficacy and Mechanisms of Escitalopram in Drug-Naïve First-Episode Major Depressive Disorder NCT07480525	Peking University	N/A
Not Yet Recruiting	ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major De NCT07474974	Polytechnic Institute of Porto	N/A
Not Yet Recruiting	Enhancing Operational Readiness With Digital Self-Managed Cognitive Behavioral Therapy for Insomnia (CBTI) NCT07335276	Madigan Army Medical Center	N/A
Not Yet Recruiting	Mechanisms Of Change in Psychotherapy: The Effects of Cognitive Behavioral Therapy and Psychodynamic Therapy i NCT07408687	University of Oslo	N/A
Recruiting	Nutritional Intervention for College Students With Depression NCT07490782	University of California, San Diego	N/A
Not Yet Recruiting	Depression Among Medical Students at Sohag University NCT07427277	Sohag University	—
Not Yet Recruiting	Tidal Model-Based ACT for Depression NCT07442253	Baskent University	N/A
Not Yet Recruiting	Evaluating The Impact of A Mental Health App on Depression and Resilience Among Medical Students NCT07397299	National University of Malaysia	N/A
Not Yet Recruiting	To Investigate the Change of Brain and Autonomic Function From Different Protocols of Repeated Transcranial Ma NCT07327385	Tri-Service General Hospital	N/A
Not Yet Recruiting	Dynamic Networks in Depression Treatment: Mechanisms of Change in Pharmacological, Psychological and Combined NCT07488910	Goethe University	Phase 4
Recruiting	Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use NCT06878859	Massachusetts General Hospital	N/A
Not Yet Recruiting	Interest of Adaptated Physical Activity (APA) on the K Recovery Constant, Reflecting the Rate of Muscle Oxygen NCT07417709	Centre Hospitalier Universitaire de Besancon	N/A
Not Yet Recruiting	Discontination of Antidepressants in Remitted Depression NCT07393919	Universita di Verona	Phase 4
Not Yet Recruiting	Ultra-brief Psychological Treatments for Emotional Symptoms and Disorders NCT06909669	Universidad de Córdoba	N/A
Recruiting	Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot NCT07390786	Medical University of South Carolina	N/A
Recruiting	Behavioral Health Collaborative Care Model in an ICU Recovery Clinic NCT07372586	Medical University of South Carolina	N/A
Enrolling By Invitation	Clinical Impact of an Anti-Inflammatory Diet in Anxiety and Depression With AI NCT07398040	Universidad de Zaragoza	N/A
Recruiting	No Time to Wait: Single Session Intervention NCT07383467	United Christian Hospital	N/A
Not Yet Recruiting	Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental NCT07060690	Francesc Colom, PsyD, PhD	N/A
Not Yet Recruiting	Escitalopram Plasma Concentrations in Premenopausal and Postmenopausal Women NCT07259525	Eskisehir Osmangazi University	—
Not Yet Recruiting	Psilocybin to Treat Depression in Spinal Cord Injury NCT07251491	James J. Peters Veterans Affairs Medical Center	Phase 1 / Phase 2
Not Yet Recruiting	Selenium Supplementation for Improving Depression in Children and Adolescents: Efficacy and Mechanistic Study NCT07203144	First Affiliated Hospital of Chongqing Medical University	Phase 2
Not Yet Recruiting	Video Intervention to Reduce Depression-related Stigma Among Adolescents NCT07282366	Jian-Jun Ou	N/A
Recruiting	Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided Intermittent Theta Burs NCT07026461	Region Örebro County	Phase 4
Recruiting	Real-world Clinical Response to Trazodone in Italy, Poland, and Romania NCT07377682	Aziende Chimiche Riunite Angelini Francesco S.p.A	—
Recruiting	A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder NCT06793397	Cybin IRL Limited	Phase 3
Not Yet Recruiting	Development and Validation of a Comprehensive Management Service Package for Older Adults With Multimorbidity NCT07151430	Xuanwu Hospital, Beijing	N/A
Recruiting	Improving Treatment for Depression in General Practice Using a Step-by-Step Care Plan. NCT07263321	Aalborg University Hospital	N/A
Not Yet Recruiting	Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder NCT07282678	Pulvinar Neuro, LLC	N/A
Recruiting	IMST for Dementia Risk Reduction NCT07349706	Florida State University	N/A
Recruiting	Epigenetic Enhancement of Cognitive Training in Aging Mood Disorder Populations NCT07404085	Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital	N/A
Recruiting	Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects NCT07490353	Medical University of Vienna	Phase 1
Recruiting	Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression NCT07250893	St. Joseph's Healthcare Hamilton	N/A
Not Yet Recruiting	Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Pr NCT07210112	Centre Hospitalier St Anne	Phase 2
Not Yet Recruiting	Mental Health Mission Mood Disorder Cohort Study NCT07189689	University of Oxford	—
Enrolling By Invitation	Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients NCT07200739	Zealand University Hospital	—
Not Yet Recruiting	Clinical Study of Compound Ciwujia Granules in the Treatment of Depression NCT07085143	Shanghai Mental Health Center	Phase 4
Recruiting	Integrated Care for Older Adults With Major Depression and Physical Multimorbidity - The I-CONNECT NCT07211750	KU Leuven	N/A
Recruiting	Fluoxetine on Emotional Experience (FLEX) Study NCT07424781	University of Oxford	N/A
Not Yet Recruiting	Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) in Adolescents With First-episode D NCT07185464	First Affiliated Hospital of Chongqing Medical University	N/A
Not Yet Recruiting	Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) Combined With Stable Medication in NCT07185451	First Affiliated Hospital of Chongqing Medical University	N/A
Recruiting	Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression NCT07188623	Stanford University	N/A
Recruiting	The Effectiveness and Efficacy of an Online Cognitive Behavioral Psychotherapeutic Program NCT07255131	Rakitzi, Stavroula	N/A
Recruiting	Digital Intervention for Physical Activity NCT07130734	Auburn University	N/A
Recruiting	Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression NCT07422519	Hospital Universitari Vall d'Hebron Research Institute	N/A
Recruiting	Efficacy and Safety of Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) i NCT07185438	First Affiliated Hospital of Chongqing Medical University	N/A
Recruiting	Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression NCT07082998	Massachusetts General Hospital	N/A
Not Yet Recruiting	Intermittent Fasting for Inflammation and Depression in Spinal Cord Injury NCT06807528	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	N/A
Not Yet Recruiting	Stratified Pharmacological Approaches for Regulating Circuit-Level Effects NCT07022405	Stanford University	Phase 2
Recruiting	Feasibility and Acceptability of an E-learning Dialectical Behavior Therapy Skills Course NCT07088939	University of Windsor	N/A
Enrolling By Invitation	Effect of Theta-burst rTMS Therapy on the Clinical and Cognitive Symptoms of Patients With Therapy Resistant D NCT07207239	Semmelweis University	N/A
Recruiting	PERSONAE - a Personalized Online Treatment of Depression NCT07113548	Region of Southern Denmark	N/A
Completed	A Qualitative Analysis of Youth Responses to Depression Education Delivered on Social Media NCT07100548	Ludwig-Maximilians - University of Munich	—
Withdrawn	Investigating the Protective Impact of LY-2940094 on Stress-induced Depression- and Anxiety-related Phenotypes NCT06786637	Mclean Hospital	Phase 2
Recruiting	Integrating Digital Phenotypes and AI-Driven Cognitive-Behavioral Therapy: Advancing Precision Medicine in Dep NCT07500714	National Science and Technology Council, Taiwan	N/A
Recruiting	Brief Trial of ACT-i for Adults With Chronic Insomnia NCT07048600	Babes-Bolyai University	N/A
Recruiting	Clinical Trial to Investigate the Safety and Efficacy of Two Dexamfetamine Sulfate Formulations in Adults With NCT06967857	Prof. Dr. Frank Behrens	Phase 2
Enrolling By Invitation	The Effect of Digital Markers in the Self-management of Depressive Symptoms NCT06919133	Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital	N/A
Recruiting	Unified Protocol Group Treatment in a University Outpatient Clinic NCT07129941	University of Bergen	N/A
Active Not Recruiting	A Randomized Controlled Trial of Robotic Support for Enhanced Later Life (RoSELL) NCT07102017	Shanghai Jiao Tong University School of Medicine	N/A
Recruiting	ACT_for Alcohol Use Disorder and Depression NCT06620276	Centre hospitalier de l'Université de Montréal (CHUM)	N/A
Not Yet Recruiting	Designing and Pilot Testing a Just-in-time Adaptive Intervention (JITAI) for Adolescent Depression Treatment i NCT06875726	University of Washington	N/A
Recruiting	Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use NCT06920238	Trustees of Dartmouth College	Phase 1
Recruiting	Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder NCT06874374	Pulvinar Neuro, LLC	N/A
Enrolling By Invitation	Intern Health Study 2025 NCT07052357	University of Michigan	N/A
Recruiting	TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children NCT07478796	Poznan University of Medical Sciences	Phase 4
Completed	Enhancing Depression Literacy and Reducing Stigma in Adolescents Through Social Media NCT07061600	Ludwig-Maximilians - University of Munich	N/A
Recruiting	Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort NCT07485387	Korea University	—
Not Yet Recruiting	Efficacy and Mechanism of Transcranial Temporal Interference Stimulation (tTIS) in the Treatment of Adolescent NCT06902064	Xijing Hospital	N/A
Recruiting	Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression NCT06854367	Centre for Addiction and Mental Health	N/A
Recruiting	A Novel Blood Test as a Biomarker in Mental Health NCT06856161	Fraser Health	—
Completed	A Megastudy of Single-Session Interventions for Depression NCT06856668	Northwestern University	N/A
Recruiting	Personalized Ultrasonic Brain Stimulation for Depression (R61) NCT06902298	Brian Mickey	Phase 1 / Phase 2
Enrolling By Invitation	Digital Phenotypes for Predicting Depression NCT07151846	Korea University Anam Hospital	—
Recruiting	Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic D NCT06795451	University of Cincinnati	Phase 1 / Phase 2
Active Not Recruiting	Relief From Stress Via Social Protection in Senegal NCT06698471	Georgetown University	N/A
Recruiting	Prevalence and Severity of Depression in Coronary Artery Disease Patients NCT06740396	Al-Nahrain University	—
Recruiting	Mood And Kids diEt (MAKE-It) Pilot Trial NCT06716034	The Hospital for Sick Children	N/A
Enrolling By Invitation	Mental Health, Intellectual and Neurodevelopmental Disorder Detection With Artificial Intelligence Models NCT06792175	Psyrin Inc.	—
Recruiting	A Feasibility Study of Nature-based Health Interventions for People With Mild to Moderate Anxiety, Depression NCT06981000	University of Copenhagen	N/A
Enrolling By Invitation	Evaluating the Effectiveness and Acceptability of a GPT-4o and RAG-Based Voice Chatbot for Depression Screenin NCT06801925	University College, London	—
Recruiting	Internet-based Support for Adjustment to Prostate Cancer NCT06766526	Linkoeping University	N/A
Recruiting	Assessment of the Efficacy and Safety of Fecal Microbiota Transplantation (FMT) in Patients With Major Depress NCT06692361	Gang Wang	N/A
Not Yet Recruiting	Association of Beta Blocker Use with Depressive Outcomes NCT06743633	Chitkara University	—
Not Yet Recruiting	Impact of Behavioral Activation on Depression and Quality of Life in Patients with Colon Cancer NCT06745700	Region Västmanland	N/A
Active Not Recruiting	Perioperative Depression, an Observational Cohort Study NCT06783842	Karolinska Institutet	—
Recruiting	Precision Subclassification of Mental Health in Diabetes: Digital Twins for Precision Mental Health to Track S NCT07212075	Forschungsinstitut der Diabetes Akademie Mergentheim	—
Enrolling By Invitation	Intervention to Reduce HIV Related Stigma Among Pregnant and Postpartum Women NCT07064928	University of California, San Francisco	N/A
Active Not Recruiting	Link Between Reduction of Suicide Ideation by Esketamine in Add-On and Initial Levels of Psychological Pain an NCT07199179	University Hospital, Montpellier	—
Recruiting	Meditative Neurofeedback for Depression NCT06675240	University of California, San Diego	N/A
Recruiting	Development of Attentional Biases for Affective Cues in Infants of Mothers With Depression NCT06835855	Binghamton University	N/A
Recruiting	Development and Application of Precision Treatment Strategies for Common Mental Disorders NCT06729541	Peking University	N/A
Recruiting	The Effect of PROSE or Scleral Lenses on Mental Health NCT07195721	Boston Sight	—
Completed	Peer-Supported E-Health Intervention for College Student Weight Management and Mental Health NCT06966661	Jinan University Guangzhou	N/A
Recruiting	Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking NCT07050355	Medical University of South Carolina	N/A
Not Yet Recruiting	Lithium for Prevention of Cognitive Declining in Mood Illnesses NCT06662526	University of Chile	Phase 4
Recruiting	Effects of Low-intensity Transcranial Magnetic Stimulation on Major Depressive Disorder, and on 5-hydroxyindol NCT06667180	Universidad de Guanajuato	Phase 1 / Phase 2
Enrolling By Invitation	Combined Effect of TCC-I and BATD on Depressive Symptoms and Insomnia NCT06633263	University of Liege	N/A
Recruiting	Open-Label Psilocybin Study in Transdiagnostic Population NCT06442423	Yale University	Phase 1
Recruiting	Nurse-led Primary Healthcare Intervention Model in Women's Health Management in Hong Kong NCT06628388	The University of Hong Kong	N/A
Completed	Generated AI-informed Intervention (Emohaa) vs Group ACT vs WL on Emotional Distress NCT06735807	Central University of Finance and Economics, China	N/A
Active Not Recruiting	Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder NCT06670040	Children's Hospital Medical Center, Cincinnati	N/A
Recruiting	Individualized Exploration of Aerobic Exercise-assisted Treatment of Depression NCT06594588	Peking University	N/A
Active Not Recruiting	Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections: Translating Epidemiology NCT07453420	Shalvata Mental Health Center	—
Completed	Effectiveness of Behavioral Activation Group Therapy for Patients With Depression at the Community in Thanh Ho NCT07527312	Hanoi Medical University	N/A
Recruiting	Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health Trajectories NCT06978452	Douglas Mental Health University Institute	—
Completed	Autism Genomics Sweden - Genetic Guidance and Information Trial NCT06740760	Karolinska Institutet	N/A
Completed	Integrative Group Psychotherapy (Terebenin's Method) in Adults With Subclinical and Mild/Moderate Anxiety and NCT06863948	S.LAB (SOLOWAYS)	N/A
Recruiting	Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women NCT06646692	University of California, Los Angeles	N/A
Completed	A Precision Medicine Approach to the Prevention of Depression in Patients With Atrial Fibrillation NCT07178691	University of Southern Denmark	N/A
Completed	Is Betwixt App Effective and Acceptable? NCT06958887	University of Nottingham	N/A
Active Not Recruiting	Racial Disparities in Antidepressant Treatment After a Psychiatric Consultation NCT06799078	Centre for Addiction and Mental Health	—
Recruiting	RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS NCT05977439	Medical University of South Carolina	—
Recruiting	Baby Swim As an Intervention for Depressive Symptoms and Lacking Attachment During the Postpartum Period NCT06807801	Uppsala University	N/A
Recruiting	AtWork: The Relation Between Cognitive Functioning, Common Mental Disorders and Work Functioning NCT07349550	Norwegian University of Science and Technology	—
Completed	Sustained Ketamine Effectiveness for Suicidal Ideation NCT06806475	University Hospital, Montpellier	—
Recruiting	Investigating the Impacts of Early Life Experience on the Brain & Behaviour NCT06823492	University of Manchester	—
Completed	Cognitive Flexibility in Depression and TMS Response NCT06775054	Gulhane Training and Research Hospital	N/A
Completed	BIOMARKERS FOR DRUG SELECTION IN DEPRESSION NCT07269886	Neomente SAS	—
Completed	Chart Review of Patients Undergoing Ketamine Treatments for Depression NCT07099235	Sunnybrook Health Sciences Centre	—
Completed	An Interactive Mobile Health (mHealth) App as Intervention for High Anxiety and Depression in College Students NCT07017569	Texas A&M University	N/A
Active Not Recruiting	Measurement of Serum Inflammatory Markers in Patients Treatment-resistant Depression Given Psilocybin NCT07164755	King's College London	—
Completed	Sleep/Wake Cycle and Depression: An Imaging and Treatment Study NCT04350567	Stony Brook University	N/A
Completed	2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and NCT07097025	Dr.Yoav Domany	—
Recruiting	Brain Imaging of Cognition Inn Schizophrenia and Depression NCT04159662	The Royal Ottawa Mental Health Centre	—
Completed	Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System NCT03272230	Institut National de la Santé Et de la Recherche Médicale, France	N/A
Completed	Phase 1 Study To Test the Bioequivalence Between Two 25 mg Tablets vs. One 50 mg Tablet Under Fast/Fed Conditi NCT01190514	Pfizer	Phase 1