NCT06729541

Development and Application of Precision Treatment Strategies for Common Mental Disorders

Development and Application of Precision Treatment Strategies for Patients with Depression, Bipolar Disorder, and Schizophrenia: a Multicenter Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: Peking University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Schizophrenia (SCH), major depressive disorder (MDD), and bipolar disorder (BPD) are prevalent, disabling psychiatric conditions that not only cause significant suffering for affected individuals and their families but also impose a substantial socioeconomic burden and challenge societal well-being. Addressing the mental health challenges faced by patients, their families, and the healthcare system is a critical global public health priority. However, a comprehensive and systematic precision treatment approach for mental disorders remains largely absent in current clinical practice. This study leveraged pharmacogenomic insights tailored specifically to the Chinese Han population to guide individualized medication selection. The approach incorporated quantitative assessment-based treatment protocols alongside therapeutic drug monitoring throughout the treatment process. The overarching goal was to establish a systematic precision treatment model that integrates "quantitative assessment-based treatment + pharmacogenomics + therapeutic drug monitoring." This model aims to optimize treatment outcomes, enhance safety, improve efficiency, and reduce costs, ultimately benefiting patients with psychiatric disorders.

Conditions

• Depression - Major Depressive Disorder
• Schizophrenia Disorders
• Bipolar Disorder (BD)

Interventions

Type	Name	Description
OTHER	Multigenetic Pharmacogenomics-Guided Treatment (MPGT)	In the guidance group, drug types and dosages were adjusted based on the results of Pharmacogenetic TESTING.

Timeline

• Start date: 2024-11-11
• Primary completion: 2026-07-01
• Completion: 2026-12-01
• First posted: 2024-12-11
• Last updated: 2024-12-12

Locations

1 site across 1 country: China