NCT07207239

Effect of Theta-burst rTMS Therapy on the Clinical and Cognitive Symptoms of Patients With Therapy Resistant Depression and Response Prediction With Neuroimaging Methods.

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 54 (estimated)
• Sponsor: Semmelweis University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary aim of the study is to find the combination of neuroimaging-related markers, demographics, and clinical characteristics that predict the response of patients with therapy-resistant depression to theta-burst rTMS treatment. The secondary aim is to monitor the cognitive effects of TMS therapy.

Conditions

• Transcranial Magnetic Stimulation, Repetitive
• Depression - Major Depressive Disorder

Interventions

Type	Name	Description
DEVICE	repetative Transcranial Magnetic Stimulation (rTMS), theta-burst protocol	Theta-burst rTMS treatment stimulates the left Dorsolateral Prefrontal Cortex (DLPFC). The TBS parameters the investigators adopted follows the standard TBS protocols, with 3-pulse 50-Hz bursts given every 200 ms (at 5 Hz) and an intensity of 100% active motor threshold. The investigators plan to deliver 1800 stimuli to the left DLPFC daily in 9.5-minute blocks for four weeks.

Timeline

• Start date: 2025-06-13
• Primary completion: 2028-06-13
• Completion: 2028-06-13
• First posted: 2025-10-03
• Last updated: 2025-10-03

Locations

1 site across 1 country: Hungary