| Not Yet Recruiting | Identification of Possible Trigeminal Neuralgia NCT07453511 | University College, London | — |
| Not Yet Recruiting | Effect of Play Dough, Slime, and Plush Toys on Dental Anxiety and Pain in Children During Dental Treatment NCT07445594 | Afyonkarahisar Health Sciences University | N/A |
| Not Yet Recruiting | Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry NCT07231614 | Universidad Austral de Chile | Phase 4 |
| Recruiting | A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients NCT07239505 | Fayoum University | N/A |
| Not Yet Recruiting | A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Post NCT06269406 | S.LAB (SOLOWAYS) | N/A |
| Recruiting | Photobiomodulation and Tooth Analgesia NCT06691269 | University of Maryland, Baltimore | N/A |
| Recruiting | Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial NCT07130760 | Aula Dental Avanzada | N/A |
| Completed | Clinical Outcomes of Mandibular Primary Molar Extraction Using Physics Forceps in Children NCT07366788 | Damascus University | N/A |
| Recruiting | Exploration of the Utility of Dental-dedicated MRI for Dentistry NCT06948162 | Donald Nixdorf | — |
| Not Yet Recruiting | Meloxicam Versus Ibuprofen for Pain Control After Third Molar Exodontia in Adult Patients NCT06704113 | Universidad Austral de Chile | Phase 4 |
| Completed | Evaluation of Pulpal and Salivary Neuropeptides in Dental Pain NCT07330024 | Kahramanmaras Sutcu Imam University | — |
| Completed | The Effect of Rubber Dam on Objective and Subjective Parameters of Stress During Dental Treatment in Children NCT06779448 | Izmir Katip Celebi University | N/A |
| Completed | XP-Endo Finisher on Postoperative Pain in Retreatment Cases Using Mtwo R Files NCT06625853 | Hams Hamed Abdelrahman | N/A |
| Completed | Technology-based Distraction Techniques in Managing Children With Attention-deficit/Hyperactivity Disorder NCT07411157 | Alexandria University | N/A |
| Completed | Self-Reported Pain in Children Submitted to Single Infiltration of Articaine During Primary Molar Extraction NCT05443009 | Universidade Federal de Santa Catarina | Phase 4 |
| Withdrawn | Nonpharmacologic Reduction of Periprocedural Pain and Anxiety in Dentistry NCT05194449 | Hypnalgesics, LLC | N/A |
| Recruiting | Dental Block for Pain Relief in ED Dental Pain Patients NCT05351099 | University of California, San Francisco | — |
| Completed | Effect of EDDY Sonic Irrigation on Root Canal Microbiota and Pain in Asymptomatic Apical Periodontitis NCT07120126 | Abdulkadir Tiftik,DDS | N/A |
| Completed | Self Medication in Odontology (AUDE) NCT04949126 | University Hospital, Clermont-Ferrand | — |
| Completed | Buffered Local Anesthetic NCT05757648 | University Hospitals Cleveland Medical Center | Phase 4 |
| Completed | Comparison of Different Pain Rating Scales in Patients With Symptomatic Teeth NCT04231955 | Istanbul Medipol University Hospital | N/A |
| Completed | A Study of Acetaminophen for Post Surgical Dental Pain NCT04018612 | Nevakar, Inc. | Phase 2 |
| Completed | The Impact of Minimally Invasive Restorative Techniques on Dental Pain in Pregnant Women NCT04573608 | Nourhan M.Aly | Phase 2 |
| Completed | Validation of Child Drawing Hospital Scale (CD: H) and the Place of the Drawing in the Evaluation of Dental An NCT05236101 | Tokat Gaziosmanpasa University | N/A |
| Completed | Dental Pain Study of Analgesics in Patients Undergoing Molar Removal NCT03652818 | Nevakar, Inc. | Phase 2 |
| Completed | Pain Perception: on Relationships Between Dental Anxiety and Olfaction NCT05369936 | Qassim University | N/A |
| Completed | Nonpharmacologic Reduction of Periprocedural Distress and Drug Use NCT03328208 | Hypnalgesics, LLC | N/A |
| Completed | A Split Mouth Trial to Compare Microneedles vs. Standard Needles in Dental Anaesthetic Delivery NCT02966067 | University of Dublin, Trinity College | N/A |
| Completed | Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction NCT02517905 | Pacira Pharmaceuticals, Inc | Phase 3 |
| Completed | Study of Acetaminophen (ACE) in Post-operative Dental Pain NCT02320708 | Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc. | Phase 2 |
| Terminated | Safety and Efficacy Study of NTC-510 to Treat Pain Following Dental Surgery of Third Molars NCT02161354 | NanoSHIFT LLC | Phase 2 |
| Completed | Methodological Validation of Ibuprofen Verses Placebo for Post Operative Pain After Third Molar Extraction Sur NCT02096926 | Lotus Clinical Research, LLC | Phase 4 |
| Completed | Study of Long-Acting Acetaminophen in Postoperative Dental Pain NCT01960114 | McNeil Consumer Healthcare Division of McNEIL-PPC, Inc. | Phase 2 |
| Completed | Maxigesic 325 Acute Dental Pain Study NCT01420653 | AFT Pharmaceuticals, Ltd. | Phase 3 |
| Completed | Impact of Dental Pain on the Quality of Life NCT02443207 | Ana Flavia Granville-Garcia | — |
| Completed | Efficacy of the Dental Vibe Unit for Use of Reduction or Elimination of Pain During Dental Anesthetic Injectio NCT02414620 | University of the Pacific | Phase 4 |
| Completed | Study of Naproxen Capsules to Treat Dental Pain NCT01229228 | Iroko Pharmaceuticals, LLC | Phase 2 |
| Completed | Efficiency Evaluation of Intradiploic Intra-osseus Anesthesia Versus Inferior Alveolar Nerve Block NCT01177423 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Evaluation of the Efficacy and Safety of Diclofenac HPBCD 75mg/ml in Treatment of Pain Following Dental Surger NCT00943098 | IBSA Institut Biochimique SA | Phase 3 |
| Completed | Evaluation of the Efficacy and Safety of Diclofenac HPBCD 25, 50 mg/ml in the Treatment of Post-surgical Pain NCT00942448 | IBSA Institut Biochimique SA | Phase 3 |
| Completed | Safety and Efficacy Study of XPF-001 to Treat Pain Following Wisdom Tooth Extraction NCT00954356 | Xenon Pharmaceuticals Inc. | Phase 2 |
| Completed | Study of Diclofenac Capsules to Treat Dental Pain NCT00985439 | Iroko Pharmaceuticals, LLC | Phase 2 |
| Completed | Phase 2 Study of Indomethacin Capsules to Treat Dental Pain NCT00964431 | Iroko Pharmaceuticals, LLC | Phase 2 |
| Completed | Study of Buprenorphine HCl Buccal Film in the Treatment of Dental Pain NCT00941304 | BioDelivery Sciences International | Phase 2 |
| Completed | Single Dose Study of N1539 in the Treatment of Pain Secondary to Dental Impaction Surgery NCT00945763 | Alkermes, Inc. | Phase 2 |
| Completed | The Effects of Potassium Nitrate in Reducing Dentinal Hypersensitivity NCT01587950 | GlaxoSmithKline | Phase 1 |
| Completed | Analgetic Effect of Nitrousoxide-oxygen Inhalation for Dental Treatment of Children NCT01022294 | University of Aarhus | N/A |
| Unknown | Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel NCT00846690 | The University of Texas Health Science Center, Houston | Phase 4 |
| Completed | Dose Response of a Tubule Occlusion Agent NCT01075256 | GlaxoSmithKline | Phase 4 |
| Completed | A Study of ARRY-371797 in Subjects Undergoing Third Molar Extraction NCT00663767 | Pfizer | Phase 2 |
| Completed | A Study of ARRY-371797 in Subjects Undergoing Third Molar Extraction NCT00542035 | Pfizer | Phase 2 |
| Completed | Dental Pain (Following Third Molar Tooth Extraction) Study NCT00114049 | GlaxoSmithKline | Phase 3 |
| Withdrawn | Maxi-Analgesic Phase 2 Study to Compare the Analgesic Effects in Different Dosing Groups to Treat Teeth Extrac NCT01104844 | AFT Pharmaceuticals, Ltd. | Phase 2 |