| Not Yet Recruiting | Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis: A Trans-regional Digital Health E NCT07280871 | Luxembourg Institute of Health | — |
| Enrolling By Invitation | Clinical Impact Through AI-assisted MS Care - A Prospective Multi-center Study NCT07032246 | icometrix | N/A |
| Recruiting | Predictive Value of the Optic Nerve Involvement in Clinically Isolated Syndrome NCT06455332 | University Hospital, Lille | N/A |
| Recruiting | Glymphatic MRI in Clinically Isolated Syndrome NCT06274671 | University of Exeter | — |
| Recruiting | Clinical Impact Through AI-assisted MS Care - A Retrospective Multi-center Observational Study. NCT06280755 | icometrix | — |
| Recruiting | Sun Yat-Sen Cohort of CNS Idiopathic Inflammatory Demyelinating Diseases NCT06541626 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Completed | A Study to Assess the Effectiveness and Safety of Mayzent in Chinese Patients With Relapsing Forms of Multiple NCT06395909 | Novartis | — |
| Completed | Study to Assess Changes in Immunoglobulins in Patients With Relapsing Multiple Sclerosis Treated With Anti-CD2 NCT06526000 | Novartis | — |
| Unknown | Implementation of a Novel Functional Eye-Tracking Biomarker for Multiple Sclerosis NCT05277740 | McGill University | — |
| Enrolling By Invitation | Visual Processing Speed and Objective Analysis of Ocular Movements in Multiple Sclerosis NCT05706220 | Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA | — |
| Completed | A Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy NCT04998812 | Hoffmann-La Roche | Phase 4 |
| Recruiting | China National Registry of Neuro-Inflammatory Diseases NCT05154370 | Beijing Tiantan Hospital | — |
| Recruiting | Autoimmune Intervention Mastery Course Study NCT05057676 | Terry L. Wahls | N/A |
| Recruiting | MS-ResearchBiomarkerS NCT05204459 | Cedars-Sinai Medical Center | — |
| Recruiting | Pathogenicity of B and CD4 T Cell Subsets in Multiple Sclerosis NCT04798651 | University Hospital, Bordeaux | N/A |
| Completed | A Study Evaluating B Cell Levels In Infants Of Lactating Women With CIS Or MS Receiving Ocrelizumab NCT04998851 | Hoffmann-La Roche | Phase 4 |
| Terminated | Assessing the Feasibility of the MSPT Device in Routine Clinical Practice in the Swiss Healthcare System NCT04599023 | Insel Gruppe AG, University Hospital Bern | — |
| Active Not Recruiting | Impact of Ocrelizumab on Cerebrospinal Fluid Biomarkers at Multiple Sclerosis Onset NCT04466150 | University of California, San Francisco | Phase 4 |
| Completed | Ocrelizumab in Breastmilk NCT04387110 | University of California, San Francisco | — |
| Active Not Recruiting | Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis NCT04009005 | Terry L. Wahls | N/A |
| Terminated | Minocycline in MS: Confirmation of Benefit NCT04291456 | University of Calgary | Phase 3 |
| Unknown | Isoelectric Focusing of Tears in Children With Radiologically Isolated or Clinically Isolated Syndrome NCT03979391 | Lille Catholic University | N/A |
| Completed | Understanding Magnetic Resonance Imaging in Multiple Sclerosis NCT03872583 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Completed | Evaluation of an Automatic Segmentation Software (Pixyl.Neuro) to Track Lesions in Multiple Sclerosis Patients NCT03438357 | Centre Hospitalier Universitaire de Nīmes | — |
| Unknown | Risk Factors in Early Multiple Sclerosis NCT03586986 | University of Colorado, Denver | — |
| Unknown | Longitudinal Effect of Vitamin D3 Replacement on Cognitive Performance and MRI Markers in Multiple Sclerosis P NCT03610139 | American University of Beirut Medical Center | N/A |
| Completed | The Effect of a Gluten Free Diet on the Permeability of the Blood Brain Barrier in Patients With CIS NCT03451955 | University of Copenhagen | N/A |
| Completed | Social Cognition in Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculograp NCT04705610 | Association de Recherche Bibliographique pour les Neurosciences | N/A |
| Recruiting | Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA) NCT06940323 | University of California, San Francisco | — |
| Unknown | Clinical Importance of Glucose Regulation in Relapsing MS NCT03004079 | University of Virginia | — |
| Completed | Immunoadsorption vs. Plasmapheresis in the Escalation Therapy of Relapse in Multiple Sclerosis NCT02671682 | Albert Christian Ludolph, Prof. | N/A |
| Completed | Mitochondrial Dysfunction and Disease Progression NCT02549703 | Icahn School of Medicine at Mount Sinai | — |
| Completed | Effectiveness of Rebif® in Clinically Isolated Syndrome and Relapsing Multiple Sclerosis Using RebiSmart™ NCT02254304 | Merck KGaA, Darmstadt, Germany | Phase 4 |
| Completed | Clinical Monitoring, MRI and Neuro-Ophthalmology of a Cohort of Patients With a Clinically Isolated Syndrome ( NCT03541226 | University Hospital, Lille | — |
| Completed | Dose-related Effects of Vitamin D3 on Immune Responses in Patients With Clinically Isolated Syndrome NCT01728922 | University College Dublin | Phase 1 / Phase 2 |
| Completed | A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple Sclerosis NCT01737372 | John F. Foley, MD | — |
| Completed | Tear Analysis by Isoelectric Focusing in Clinically Isolated Syndrome as Multiple Sclerosis Criterion NCT02043964 | Lille Catholic University | N/A |
| Unknown | Cohort Study of Clinically Isolated Syndrome and Early Multiple Sclerosis NCT01371071 | Charite University, Berlin, Germany | — |
| Terminated | Nanocort in Acute Exacerbation of Relapsing-Remitting Multiple Sclerosis (MS) NCT01039103 | Galapagos NV | Phase 2 |
| Completed | Long-term Follow-Up of Patients Who Participated in Study 27025 (REFLEX) NCT00813709 | Merck KGaA, Darmstadt, Germany | Phase 3 |
| Terminated | Longitudinal Study in Clinically Isolated Syndrome (CIS) Patients Treated With Interferon Beta NCT00819897 | Centre Hospitalier Universitaire de Nice | — |
| Completed | AT RISK FOR MS - Clinical Conversion of Female Monozygotic Twins Discordant for CIS/MS NCT00617383 | The University of Texas Health Science Center, Houston | — |
| Terminated | Open Label Extension of Prior TERMS Study to Treat Relapsing Forms of Multiple Sclerosis NCT00595920 | Opexa Therapeutics, Inc. | Phase 2 |
| Completed | A Prospective Study Looking at the Use of Rebif® in Subjects With Clinically Isolated Syndrome NCT00287079 | Merck KGaA, Darmstadt, Germany | Phase 3 |
| Completed | Safety/Effectiveness of Adding Monthly Dexamethasone to Weekly Avonex for MS NCT00232193 | Providence Multiple Sclerosis Center | — |