| Not Yet Recruiting | A Behavioral Application for Improving Smoking Cessation Among Smokers NCT07493252 | Fred Hutchinson Cancer Center | N/A |
| Not Yet Recruiting | A Smartphone Application (QuitBot) for the Improvement of Smoking Cessation Among American Indians and Alaska NCT06697496 | Fred Hutchinson Cancer Center | N/A |
| Not Yet Recruiting | A Novel Tobacco Cessation Resource for Smokers With a Diagnosed or Suspected Thoracic Cancer NCT07455513 | Ohio State University Comprehensive Cancer Center | N/A |
| Not Yet Recruiting | iCanQuit Smoking Cessation Among Hispanic Adults NCT06811038 | Fred Hutchinson Cancer Center | Phase 3 |
| Not Yet Recruiting | PK/PD of Vaping THC-containing Liquids vs. Smoked Cannabis NCT06055231 | Roswell Park Cancer Institute | Phase 1 |
| Recruiting | Understanding Tobacco and Cannabis Co-Use Practices: Initiation, Escalation, and Maintenance NCT07439471 | Roswell Park Cancer Institute | — |
| Withdrawn | EQQUAL-NM for the Promotion of Smoking Cessation in Sexual and Gender Minority Young Adults in New Mexico NCT06386432 | Fred Hutchinson Cancer Center | N/A |
| Recruiting | Sensory Tests of Cigarettes for Identification of Flavors in Current Daily Smoking Adults NCT06816459 | Roswell Park Cancer Institute | EARLY_Phase 1 |
| Recruiting | Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences NCT07111234 | Ohio State University Comprehensive Cancer Center | N/A |
| Recruiting | A Digital Smoking Cessation Intervention for Helping American Indians and Alaska Natives Quit Smoking, IndigeQ NCT06145763 | Fred Hutchinson Cancer Center | N/A |
| Recruiting | Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalac NCT06763536 | Ohio State University Comprehensive Cancer Center | N/A |
| Recruiting | Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study) NCT07167225 | Roswell Park Cancer Institute | — |
| Recruiting | CONNECTing to LungCare NCT06213532 | University of California, San Francisco | N/A |
| Active Not Recruiting | Evaluating the Episodic Future Thinking Intervention for Reducing Cigarette Consumption in Cigarette Smokers NCT05825001 | Roswell Park Cancer Institute | N/A |
| Recruiting | A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior NCT06260683 | Ohio State University Comprehensive Cancer Center | N/A |
| Active Not Recruiting | Evaluation of Canakinumab in High-Risk Former-Smokers NCT06038526 | Peter Shields | Phase 2 |
| Completed | Evaluating the Impact of Synthetic Cooling Agents in Combustible Cigarettes on Smoking Perceptions and Use NCT06230159 | Ohio State University Comprehensive Cancer Center | N/A |
| Completed | Avatar-Led Digital Therapeutic for Aiding Smoking Cessation in Sexual and Gender Minority Young Adults NCT05847673 | Fred Hutchinson Cancer Center | N/A |
| Completed | Evaluating the Impact of Quitting Using Executive Function Strategy Training (QUEST) on Smoking Cessation in H NCT06745154 | Ohio State University Comprehensive Cancer Center | N/A |
| Terminated | Culturally Tailored Educational Video to Promote Lung Cancer Screening in Vulnerable Communities NCT06010355 | Thomas Jefferson University | N/A |
| Recruiting | Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of To NCT05121051 | National Cancer Institute (NCI) | Phase 2 |
| Active Not Recruiting | An Innovative Conversational Agent (Quitbot) for Smoking Cessation NCT04308759 | Fred Hutchinson Cancer Center | Phase 3 |
| Completed | Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes NCT03856515 | M.D. Anderson Cancer Center | N/A |
| Completed | mHealth Mood Management Tool (Actify) to Improve Population-Level Smoking Cessation NCT04525222 | Fred Hutchinson Cancer Center | Phase 1 |
| Recruiting | Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program NCT05008848 | Alliance for Clinical Trials in Oncology | Phase 3 |
| Completed | Free-Base Nicotine or Nicotine Salt e-Liquids in Current E-Cigarette Smokers, PeloPET Study NCT05455086 | Ohio State University Comprehensive Cancer Center | N/A |
| Completed | Appeal of Nicotine Pouches Versus Cigarettes in the Ohio Appalachia Population NCT05236894 | Ohio State University Comprehensive Cancer Center | EARLY_Phase 1 |
| Completed | Pilot Trial of a Game Embedded in a Smartphone App for Smoking Cessation NCT05227027 | University of California, San Francisco | N/A |
| Active Not Recruiting | Impact of E-cigarette Use on the Body NCT04972513 | Ohio State University Comprehensive Cancer Center | — |
| Withdrawn | Evaluating Shared Decision-Making for Lung Cancer Screening Among Chinese Populations in the United States NCT05024955 | M.D. Anderson Cancer Center | — |
| Completed | Website Smoking Cessation Intervention for the Promotion of Smoking Cessation in Low-Income Veterans NCT04502524 | Fred Hutchinson Cancer Center | Phase 1 |
| Completed | Effects of Filter Ventilation and Ventilation Information on Product Use Behaviors in Cigarette Smokers NCT04744285 | Roswell Park Cancer Institute | N/A |
| Recruiting | Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial NCT04604509 | M.D. Anderson Cancer Center | Phase 4 |
| Active Not Recruiting | Increasing Access to Smoking Cessation and Smoke Free Home Services for Low-Income Pregnant Women in Northeast NCT05051345 | M.D. Anderson Cancer Center | N/A |
| Completed | Electronic Cigarette Use During Pregnancy NCT03480373 | UConn Health | — |
| Completed | Broccoli Sprout/Broccoli Seed Extract Supplement in Decreasing Toxicity in Heavy Smokers NCT03402230 | National Cancer Institute (NCI) | EARLY_Phase 1 |
| Completed | Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent NCT02964182 | M.D. Anderson Cancer Center | N/A |
| Recruiting | Smoking Cessation Intervention Development for Homeless Youth NCT06754215 | Ohio State University Comprehensive Cancer Center | N/A |
| Completed | SmartQuit Program for Smoking Cessation NCT04510077 | Fred Hutchinson Cancer Center | N/A |