NCT06745154

Evaluating the Impact of Quitting Using Executive Function Strategy Training (QUEST) on Smoking Cessation in Homeless Young Adult Smokers

QUEST (Quitting Using Executive Function Strategy Training) Research Protocol

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: Ohio State University Comprehensive Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years – 24 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial evaluates the impact of Quitting Using Executive Function Strategy Training (QUEST) on quitting smoking (cessation) in homeless young adult smokers with an acquired brain injury (ABI). Over 70% of youth and young adults experiencing homelessness (YYEH) smoke tobacco. More than half of YYEH who smoke have made at least one attempt to quit smoking but few use evidence-based methods to increase success. In addition, 9 out of 10 of these have an acquired brain injury which may have a negative impact on successful smoking cessation. QUEST may help homeless young adult smokers with an ABI quit smoking.

Detailed description

PRIMARY OBJECTIVES: I. Gather data needed to build QUEST (Quitting Using Executive function Strategy Training), an intervention to help youth and young adults (YYEH) with executive function dysregulation better 1) access evidence-based cessation; 2) adhere to processes of evidence-based treatment; and 3) address stress to prevent relapse. II. Establish the feasibility of collecting acquired brain injury (ABI) status, and impact data sensitive to change over time (clinical and epigenetic), from YYEH tobacco users in community settings. EXPLORATORY OBJECTIVE: I. Determine if 1) executive functioning 2) mild cognitive impairment and 3) epigenetic age \& other biomarkers of health risk measures are sensitive to difference by ABI status among YYEH past week combustible tobacco users. OUTLINE: Patients receive access to the Ohio Tobacco Quitline, receive nicotine patches, gum, or lozenges for up to 8 weeks. Patients also participate in tobacco cessation counseling sessions for 5 sessions over 8 weeks. Patients additionally undergo cognitive assessment and nasal swab collection on study.

Conditions

• Cigarette Smoking-Related Carcinoma

Interventions

Type	Name	Description
PROCEDURE	Biospecimen Collection	Undergo nasal swab collection
PROCEDURE	Cognitive Assessment	Undergo cognitive assessment
OTHER	Interview	Ancillary studies
DRUG	Nicotine Replacement	Given nicotine patches, gum, or lozenges
BEHAVIORAL	Smoking Cessation Intervention	Receive access to the Ohio Tobacco Quit Line
OTHER	Survey Administration	Ancillary studies
OTHER	Tobacco Cessation Counseling	Participate in counseling sessions

Timeline

• Start date: 2023-06-26
• Primary completion: 2023-08-30
• Completion: 2023-08-30
• First posted: 2024-12-20
• Last updated: 2024-12-20

Locations

1 site across 1 country: United States