| Not Yet Recruiting | A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Adult Japan NCT07484230 | Sanofi | Phase 3 |
| Not Yet Recruiting | A Study to Investigate NPS and Symptoms in Chinese Adult Participants With CRSwNP Initiating Treatment With Te NCT07520162 | AstraZeneca | Phase 3 |
| Not Yet Recruiting | A Study to Investigate the Clinical Outcome and Quality of Life in Chinese Post-operative CRSwNP Patients NCT07446738 | AstraZeneca | — |
| Enrolling By Invitation | An Extension Study to Investigate the Long-term Safety and Tolerability of Itepekimab in Adult Participants Wi NCT07424144 | Sanofi | Phase 3 |
| Not Yet Recruiting | A Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate the Efficacy and Safety of CM326 in NCT07420257 | CSPC Baike (Shandong) Biopharmaceutical Co., Ltd. | Phase 3 |
| Recruiting | Efficacy and Safety of SHR-1905 Injection in Subjects With Chronic Rhinosinusitis With Nasal Polyps NCT07132827 | Guangdong Hengrui Pharmaceutical Co., Ltd | Phase 3 |
| Recruiting | Tapering of Biologics in Chronic Rhinosinusitis With Nasal Polyps NCT07187583 | Rigshospitalet, Denmark | Phase 4 |
| Recruiting | Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With NCT06914908 | Sanofi | Phase 2 |
| Recruiting | A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participant NCT06834347 | Sanofi | Phase 3 |
| Recruiting | A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participant NCT06834360 | Sanofi | Phase 3 |
| Completed | Efficacy of Long-Term Low Dose Macrolide Therapy in Preventing Early Recurrence of Nasal Polyps After Endoscop NCT07316959 | Fatima Jinnah Medical University | N/A |
| Not Yet Recruiting | Opening the "Black Box" on Tezepelumab's Effect on Chronic Rhinosinusitis With Severe Asthma NCT06740045 | Dr. Andrew Thamboo, MD | Phase 3 |
| Recruiting | A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polypo NCT06706817 | AstraZeneca | Phase 3 |
| Recruiting | Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis (CRS). NCT07184684 | Region Skane | Phase 2 / Phase 3 |
| Active Not Recruiting | A Study of GR1802 in Participants With Chronic Sinusitis With Nasal Polyps NCT06516302 | Genrix (Shanghai) Biopharmaceutical Co., Ltd. | Phase 3 |
| Not Yet Recruiting | Immunologic Impact of Dupilumab in Patients Suffering From Asthma and Chronic Rhinosinusitis With Polyps NCT06556264 | Dr. Andrew Thamboo, MD | Phase 4 |
| Active Not Recruiting | A Proof-of-concept Study of Lunsekimig Compared With Placebo in Adults With Chronic Rhinosinusitis With Nasal NCT06454240 | Sanofi | Phase 2 |
| Completed | A Extension Clinical Study of TQC2731 Injection in the Treatment of Chronic Sinusitis With Nasal Polyps NCT06451640 | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | Phase 2 |
| Unknown | Predictive Factors in Chronic Rhinosinusitis With Nasal Polyps NCT06459622 | Katrina Atef Habashy | N/A |
| Not Yet Recruiting | Study of CM326 in Participants With Chronic Rhinosinusitis With Nasal Polyposis NCT06372678 | Keymed Biosciences Co.Ltd | Phase 2 |
| Recruiting | Effect of Dupilumab on Nasal Epithelial Barrier Function in Patients With CRSwNP NCT06398873 | Medical University of Vienna | — |
| Withdrawn | Early-onset Dupilumab Effects in CRSwNP NCT06188871 | University of Rochester | Phase 4 |
| Not Yet Recruiting | th2 Modulation CRSwNP NCT06107101 | St. Paul's Sinus Centre | Phase 4 |
| Recruiting | Biomarkers of Response to Mepolizumab Treatment in Patients With Nasal Polyps With or Without Bronchial Asthma NCT05708300 | Aristotle University Of Thessaloniki | — |
| Unknown | Mepolizumab in the Treatment of Patients With Severe Uncontrolled CRSwNP: a Multicentric Real Life Observation NCT06258772 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Not Yet Recruiting | Proof of Concept of Remote Management of Chronic Inflammatory Airway Diseases for Patient Empowerment NCT06217419 | Azienda Ospedaliero Universitaria di Sassari | N/A |
| Unknown | Study to Evaluate Safety and Activity of TRL1068 in Chronic Rhinosinusitis NCT05355207 | Trellis Bioscience LLC | Phase 1 |
| Recruiting | Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Poly NCT06129552 | Universitaire Ziekenhuizen KU Leuven | — |
| Completed | A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Participants With Chronic Rhinosinusi NCT06164704 | Upstream Bio Inc. | Phase 2 |
| Recruiting | Identifying Predictors Of Response To Mepolizumab In CRSwNP NCT05902325 | Centre hospitalier de l'Université de Montréal (CHUM) | Phase 4 |
| Recruiting | The Role of IL5 in Epithelial Cell Integrity NCT05895929 | Johns Hopkins University | EARLY_Phase 1 |
| Active Not Recruiting | Efficacy and Safety of SHR-1905 Injection in Patients With Chronic Rhinosinusitis With Nasal Polyps NCT05891483 | Guangdong Hengrui Pharmaceutical Co., Ltd | Phase 2 |
| Active Not Recruiting | Mepolizumab Effectiveness in Patients With Chronic Rhinosinusitis, Nasal Polyps and Comorbid Severe Eosinophil NCT06069310 | National and Kapodistrian University of Athens | — |
| Terminated | Evaluation of Patient Satisfaction During Treatment With Dupilumab in Severe and Recurrent Nasosinusal Polypos NCT06017427 | IHU Strasbourg | — |
| Unknown | The Study of Long-term Outcomes of GR1802 in Patients With Chronic Rhinosinusitis With Nasal Polyps NCT06015243 | Genrix (Shanghai) Biopharmaceutical Co., Ltd. | Phase 2 |
| Completed | Mechanisms of Smell Improvement With Dupilumab. NCT05964465 | Medical University of South Carolina | Phase 4 |
| Recruiting | Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment NCT05642806 | St. Paul's Sinus Centre | Phase 4 |
| Completed | Dupilumab in Chinese Adult Participants With CRSwNP NCT05878093 | Sanofi | Phase 3 |
| Active Not Recruiting | A Real-world, Head-to-head Comparison of Dupilumab Versus Mepolizumab in Danish Patients With Chronic Rhinosin NCT05942222 | Rigshospitalet, Denmark | Phase 4 |
| Unknown | Adherence in Global Airways - Steroid Intake and Effects on Chronic Rhinosinosinutis NCT05843019 | Christiane Haase | — |
| Active Not Recruiting | Mepolizumab to CRSwNP Through 12 Months - Randomised to FESS and Non-FESS Within the First 2 Weeks NCT05598814 | Vibeke Backer | Phase 4 |
| Active Not Recruiting | The Study of GR1802 in Patients with Chronic Rhinosinusitis with Nasal Polyps NCT05873803 | Genrix (Shanghai) Biopharmaceutical Co., Ltd. | Phase 2 |
| Completed | Regulatory Post-Marketing Surveillance of Xolair® for Chronic Rhinosinusitis With Nasal Polyps NCT05626257 | Novartis Pharmaceuticals | — |
| Unknown | CST1 Predictive Model of Oral Glucocorticoid Therapy Sensitivity for Chronic Rhinosinusitis With Polyps NCT05598424 | Beijing Tongren Hospital | Phase 4 |
| Completed | A Study in Male and Female Adult Participants With Chronic Rhinosinusitis With Nasal Polyps In the Greater Gul NCT05649813 | Sanofi | — |
| Unknown | CST1-Guided Oral Glucocorticoids Management for CRSwNP NCT05598411 | Beijing Tongren Hospital | Phase 4 |
| Unknown | Adherence in Global Airways NCT05553951 | Christiane Haase | N/A |
| Completed | A Study of CM326 in Patients With Chronic Rhinosinusitis With Nasal Polyps NCT05324137 | Keymed Biosciences Co.Ltd | Phase 1 / Phase 2 |
| Recruiting | Real Life Study of Biologicals in Patients With Severe CRSwNP NCT05938972 | University Hospital, Ghent | — |
| Recruiting | Dupilumab Treatment Effects in an Ethnically Diverse Population With Chronic Rhinosinusitis With Nasal Polypos NCT05246267 | Montefiore Medical Center | — |
| Recruiting | BIOlogics in Severe Nasal POlyposis SurvEy NCT05228041 | University Hospital, Lille | — |
| Unknown | Role of Montelukast in the Management of Chronic Rhinosinusitis With Nasal Polyps. NCT05143502 | Assiut University | Phase 1 / Phase 2 |
| Completed | The Study of CM310 in Patients With Chronic Rhinosinusitis With Nasal Polyps NCT05131464 | Keymed Biosciences Co.Ltd | Phase 2 |
| Recruiting | 3D Printing to Improve Nasal Irrigation Outcome NCT06118554 | Ohio State University | N/A |
| Completed | Dupilumab in Japanese Patients With Chronic Rhinosinusitis With Nasal Polyp (SINUS-M52) NCT05049122 | Sanofi | Phase 4 |
| Unknown | Dupilumab in the Treatment of Severe Uncontrolled CRSwNP: a Multicentre Observational Real-life Study (DUPIREA NCT05529784 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Completed | EValuating trEatment RESponses of Dupilumab Versus Omalizumab in Type 2 Patients NCT04998604 | Sanofi | Phase 4 |
| Recruiting | Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Pat NCT05009758 | Medical University of Vienna | N/A |
| Completed | Aggravated Airway Inflammation: Research on Biological Treatment (Mepolizumab) NCT04823585 | Helsinki University Central Hospital | Phase 4 |
| Recruiting | Olfactory Outcomes of Dupilumab Treatment for Nasal Polyposis NCT04869436 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 4 |
| Completed | Role of Doxycycline in Chronic Rhinosinusitis With Nasal Polyps NCT05157412 | Assiut University | Phase 3 |
| Terminated | A Study to Evaluate CBP-201, Rademikibart, in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps NCT04783389 | Connect Biopharm LLC | Phase 2 |
| Completed | Dupilumab for Prevention of Recurrence of CRSwNP After ESS NCT04596189 | Centre hospitalier de l'Université de Montréal (CHUM) | Phase 4 |
| Completed | The Role of Budesonide Intrapolyp Injection in the Management of Type 2 Chronic Rhinosinusitis NCT05931744 | Kafrelsheikh University | Phase 2 / Phase 3 |
| Completed | Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis NCT04851964 | AstraZeneca | Phase 3 |
| Unknown | Endoscopic Frontal Sinus Surgery Draf III in Moderate to Severe Eosinophilic Chronic Rhinosinusitis With Polyp NCT05979662 | Ibrahim Talal Elshamy | N/A |
| Completed | Preclinical Studies of Omalizumab in Chronic Rhinosinusitis With Nasal Polyposis NCT04583501 | Johns Hopkins University | EARLY_Phase 1 |
| Completed | Tissue Immune Interaction in Nasal Polyposis NCT04628442 | University of California, San Francisco | — |
| Active Not Recruiting | Effect of Celecoxib on Postoperative Analgesia and Disease Severity in AERD Patients with CRS NCT04147013 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 4 |
| Terminated | Olfaction and Inflammation in Chronic Rhinosinusitis With Nasal Polyps NCT04104594 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Unknown | Comparing Budesonide Via MAD or INSI Prospective Cohort Study NCT04267042 | St. Paul's Hospital, Canada | EARLY_Phase 1 |
| Unknown | Mediators in Nasal Hyperreactivity in Allergic Rhinitis and Chronic Rhinosinusitis NCT04286542 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Unknown | Polysomnographic Findings in Nasal Polyposis NCT03725956 | University Hospital, Lille | N/A |
| Unknown | Effect of Oral Vitamin D3 on Chronic Rhinosinusitis Treatment in Adults With Lower Vitamin D Levels NCT02668861 | The First Affiliated Hospital of Shanxi Medical University | Phase 3 |
| Completed | Study Of PF-06817024 In Healthy Subjects, In Patients With Chronic Rhinosinusitis With Nasal Polyps And in Pat NCT02743871 | Pfizer | Phase 1 |
| Completed | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 282 in Healthy Sub NCT02170337 | Amgen | Phase 1 |