| Not Yet Recruiting | Repeat Treatment With Metered Cryospray in Patients With Chronic Obstructive Pulmonary Disease With Chronic Br NCT07468617 | CSA Medical, Inc. | N/A |
| Recruiting | Clinical Study of the Pulsed Electric Field Ablation System in Chronic Obstructive Pulmonary Disease NCT07068438 | Suzhou Hengruihongyuan Medical Technology Co. LTD | N/A |
| Not Yet Recruiting | Pulmonary Deposition of Ultrasound Rock Salt Aerosol Inhalation Therapy NCT06891274 | Jingen Xia | N/A |
| Completed | Effects of Pursed Lip Breathing Technique Versus Stacked Breathing Technique Among Chronic Bronchitis Patients NCT06242210 | Riphah International University | N/A |
| Completed | Comparison Of Blow Bottle Positive Expiratory Pressure (BBPEP) Versus Acapella Among Patient With Chronic Bron NCT06086730 | Riphah International University | N/A |
| Completed | A Study to Explore if Long-term Use of Mucinex Can Help With Symptoms in Patients With Stable Chronic Bronchit NCT05843669 | American Health Research | Phase 4 |
| Active Not Recruiting | A Clinical Evaluation of the RheOx Bronchial Rheoplasty System NCT05641207 | Energenx Medical LTD. | N/A |
| Unknown | Feasibility Study of the Pulsed Electric Field Ablation System in Treating Chronic Bronchitis NCT05771129 | Jiayuan Sun | N/A |
| Unknown | Structuring of a Lung Cancer Screening Program Including Clinical, Radiological and Biological Phenotyping Use NCT05649046 | Assistance Publique Hopitaux De Marseille | N/A |
| Unknown | Resistive Breathing Versus Inspiratory Hold Technique in Patients With Chronic Bronchitis NCT05533931 | Riphah International University | N/A |
| Unknown | Early Mobilization With and Without Chest Physiotherapy in Chronic Bronchitis Patients. NCT05646225 | Riphah International University | N/A |
| Completed | Pulmonary and Cardiac Effects of E-Cigarette Use in Pulmonary Patients Who Smoke Cigarettes NCT05610514 | University of Vermont | Phase 2 |
| Completed | Evaluation of Immunological, Microbiological and Metabolomic Profiles in COPD NCT06826560 | Medical University of Warsaw | — |
| Completed | A Multicenter Clinical Trial of Sputum DNA Testing for Lung Cancer in China NCT05337163 | Creative Biosciences (Guangzhou) Co., Ltd. | — |
| Unknown | Immunogenicity and Safety of a Third Dose and Immune Persistence of BBIBP-Corv Vaccine in Elderly People With NCT05104216 | China National Biotec Group Company Limited | Phase 4 |
| Unknown | Immunogenicity and Safety of an Inactivated COVID-19 Vaccine in Elderly People With Chronic Bronchitis and COP NCT05075083 | China National Biotec Group Company Limited | Phase 4 |
| Unknown | Immunogenicity and Safety of an Inactivated COVID-19 Vaccine in Patients Aged ≥60 Years With Chronic Bronchiti NCT05075057 | China National Biotec Group Company Limited | Phase 4 |
| Unknown | Effect of Zhuli Capsule on Phlegm-heat Syndrome (Tan-re Zheng) NCT04834531 | Zhong Wang | Phase 4 |
| Unknown | Clinical Study of the RheOx Bronchial Rheoplasty System in Treating the Symptoms of Chronic Bronchitis NCT04677465 | Gala Therapeutics, Inc. | N/A |
| Terminated | A Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Participants With Mild to Moderate C NCT04441788 | Ionis Pharmaceuticals, Inc. | Phase 2 |
| Completed | A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD an NCT04631016 | AstraZeneca | Phase 2 |
| Active Not Recruiting | RejuvenAir® System Trial for COPD With Chronic Bronchitis NCT03893370 | CSA Medical, Inc. | N/A |
| Unknown | Metered Cryospray for the Treatment of Patients With Chronic Obstructive Pulmonary Disease With Chronic Bronch NCT03892694 | CSA Medical, Inc. | N/A |
| Completed | Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE) NCT04069312 | Johns Hopkins University | Phase 4 |
| Unknown | RheOx Registry Study in Europe NCT04182841 | Gala Therapeutics, Inc. | N/A |
| Withdrawn | VX-770 for the Treatment of Chronic Bronchitis NCT03251911 | University of Alabama at Birmingham | Phase 4 |
| Completed | Mortality and Symptom Burden Post Hospitalisation With COPD NCT03657121 | Northumbria Healthcare NHS Foundation Trust | — |
| Unknown | Gala Early Feasibility Study of RheOx NCT03631472 | Gala Therapeutics, Inc. | N/A |
| Withdrawn | Melodica Orchestra for Dyspnea: Safety and Feasibility Pilot NCT03653104 | VA Quality Enhancement Research Intiative | N/A |
| Completed | Gala Treatment for Chronic Bronchitis in Canada NCT03385616 | Gala Therapeutics, Inc. | N/A |
| Withdrawn | Crossover Blinded Trial of Cell Therapy Versus Placebo in COPD NCT03228121 | Lung Institute | N/A |
| Completed | The Topic Trial - Study to Determine the Safety and Efficacy of Ivacaftor NCT03085485 | University of Alabama at Birmingham | Phase 2 |
| Unknown | Studying the Airway Microenvironment in Patients Undergoing Surgical and Bronchoscopic Interventions for COPD NCT03010592 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Active Not Recruiting | BROnchoalveolar Investigations of Never-smokers With Chronic Obstruction From the Swedish CardioPulmonary bioI NCT03049202 | Karolinska Institutet | — |
| Completed | Gala FIH Feasibility Study for the Treatment of Chronic Bronchitis NCT03107494 | Gala Therapeutics, Inc. | N/A |
| Terminated | The Relationship Between GOLD Risk Group and Clinical Outcomes in a Community-based COPD Cohort NCT02838108 | Duke University | — |
| Completed | Activity Monitor Use in COPD Patients Undergoing Rehabilitation NCT02895152 | Northern Care Alliance NHS Foundation Trust | N/A |
| Withdrawn | Novel Therapies for Muco-Obstructive Lung Diseases: Testing the Transnasal Pulmonary Delivery Device in COPD/C NCT02341183 | University of North Carolina, Chapel Hill | N/A |
| Completed | Patient-Centred Innovations for Persons With Multimorbidity - Quebec NCT02789800 | Université de Sherbrooke | N/A |
| Terminated | Effect of Losartan on Airway Mucociliary Dysfunction in Patients With COPD and Chronic Bronchitis NCT02416102 | University of Miami | Phase 4 |
| Completed | Patient-Centred Innovations for Persons With Multimorbidity - Ontario NCT02742597 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Completed | The Effect of Physical Activity Promotion on Short and Long-term Outcomes in COPD NCT02099799 | VA Office of Research and Development | N/A |
| Recruiting | COPD Patient-Powered Research Network NCT02803242 | COPD Foundation | — |
| Terminated | Evaluation of the Safety of the Medical Device Simeox® NCT02061852 | Physio-Assist | N/A |
| Unknown | A Comparison Study of Two Respiratory Physical Therapy Methods and Standard Medical Treatment for Treating COP NCT02140892 | Sheba Medical Center | N/A |
| Completed | Mindfulness-based Cognitive Therapy for Chronic Obstructive Pulmonary Disease NCT02042976 | University of Aarhus | N/A |
| Completed | Postoperative Rehabilitation After Cardiac Surgery in Patients at Risk of Respiratory Complications. Effects o NCT01828788 | University Hospital, Clermont-Ferrand | Phase 2 |
| Completed | The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchit NCT03073798 | Johns Hopkins University | Phase 4 |
| Completed | Sustained Effects of Hypertonic Saline on Mucociliary Clearance in Subjects With Chronic Bronchitis NCT01792271 | University of North Carolina, Chapel Hill | N/A |
| Terminated | N-Acetylcysteine for Patients With COPD and Chronic Bronchitis NCT01739790 | University of Minnesota | N/A |
| Unknown | N-Acetylcysteine for Patients With COPD and ChronicBronchitis NCT01599884 | Center for Veterans Research and Education | N/A |
| Completed | Safety/Tolerability and Efficacy of YHD001 in Patients With Acute and Chronic Bronchitis NCT01420445 | Yuhan Corporation | Phase 2 |
| Unknown | Sunovion Brovana Versus Serevent Inspiratory Capacity High Resolution Computed Tomography NCT01361984 | University of California, Los Angeles | Phase 4 |
| Completed | A Study to Evaluate the Integrated Dose Counter on an Albuterol Hydrofluoroalkane (HFA) Metered Dose Inhaler ( NCT01302587 | Teva Branded Pharmaceutical Products R&D, Inc. | — |
| Unknown | Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Obstructive Chronic Pu NCT01431625 | Hospitales Universitarios Virgen del Rocío | Phase 4 |
| Active Not Recruiting | Study of COPD Subgroups and Biomarkers NCT01969344 | University of North Carolina, Chapel Hill | — |
| Completed | Epidemiology of Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary Disease (COPD) NCT02128529 | AstraZeneca | — |
| Completed | Evaluation of the Treatment With Klacid®SR in Patients With Lower Respiratory Tract Infection NCT01108185 | Abbott | — |
| Completed | Evaluation of Effectiveness of the Treatment After Repeated Administration of Klacid®SR NCT01130883 | Abbott | — |
| Completed | SYMPROVE III: Health Services Research Study for Treatment of the Moderate and Severe Acute Exacerbations of C NCT00879008 | Bayer | — |
| Completed | The Effect of Azithromycin in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Chronic Productiv NCT01071161 | Isala | Phase 3 |
| Completed | The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and NCT00974064 | Weill Medical College of Cornell University | — |
| Completed | VICTOR - Avelox® Intravenous (i.v.) in Acute Exacerbations of Chronic Bronchitis NCT00876577 | Bayer | — |
| Withdrawn | CryoSpray Ablation(tm)Thoracic Patient Registry NCT00785239 | CSA Medical, Inc. | — |
| Completed | Efficacy of Losartan in Preventing Progression of COPD NCT00720226 | Johns Hopkins University | Phase 4 |
| Completed | PROCHYMAL™ (Human Adult Stem Cells) for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Dise NCT00683722 | Mesoblast, Inc. | Phase 2 |
| Withdrawn | Perforomist Versus Foradil Evaluated by Inspiratory Capacity and High Resolution Computed Tomography (HRCT) NCT00633776 | University of California, Los Angeles | Phase 4 |
| Completed | Moxifloxacin Versus Amoxicillin Clavulanic Acid in Treatment of Acute Exacerbation of Chronic Bronchitis NCT00656747 | Bayer | Phase 4 |
| Completed | The Effects of Tiotropium on the Cough Reflex in Patients With Chronic Obstructive Pulmonary Disease (COPD) NCT00870896 | ThomasTruncale | EARLY_Phase 1 |
| Completed | Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Pa NCT00680056 | Federal University of São Paulo | Phase 4 |
| Completed | Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard NCT00642447 | Baqiyatallah Medical Sciences University | Phase 2 / Phase 3 |
| Completed | Pulmonary Function Changes in 10 Pack Year Smokers With Chronic Bronchitis NCT00454675 | Westside Family Medical Center, P.C. | — |
| Active Not Recruiting | Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease NCT02627872 | Karolinska Institutet | — |
| Completed | Mucus Dehydration and Evolution of Chronic Obstructive Pulmonary Disease (COPD) Lung Disease NCT00903955 | University of North Carolina, Chapel Hill | — |
| Terminated | Bronchiectasis in Chronic Obstructive Pulmonary Disease (COPD) Patients: Role of Prophylaxis NCT00524095 | University of Milan | Phase 2 |
| Completed | Real-Time Support for Exercise Persistence in COPD NCT00373932 | University of Washington | Phase 1 / Phase 2 |
| Completed | Phase 2 Study - Erdosteine in Patients With CB/COPD NCT00338507 | Adams Respiratory Therapeutics | Phase 2 |
| Completed | A Trial To Evaluate Two Antibiotics For The Treatment Of Acute Exacerbation Of Chronic Bronchitis (AECB) NCT00254566 | Pfizer | Phase 3 |
| Terminated | A Trial to Evaluate the Efficacy and Safety of Faropenem Medoxomil In the Treatment of Chronic Bronchitis NCT00255983 | Replidyne | Phase 3 |
| Completed | Macrophage Phagocytosis in COPD NCT00298389 | Imperial College London | — |
| Withdrawn | Macrophages in Smokers' Lung NCT00298402 | Imperial College London | — |
| Completed | Improving the Quality of End-of-Life Communication for Patients With Chronic Obstructive Pulmonary Disease (CO NCT00106080 | VA Office of Research and Development | N/A |
| Terminated | KEYS: Study Comparing Clinical Health Outcomes of Telithromycin Versus Azithromycin in Outpatients With Commun NCT00132951 | Sanofi | Phase 4 |
| Completed | Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation NCT00181207 | Johns Hopkins University | Phase 4 |
| Completed | Leukocyte Function in Asthma and COPD NCT00147069 | Imperial College London | — |
| Completed | Standard vs. Biofilm Susceptibility Testing in Cystic Fibrosis (CF) NCT00153634 | Seattle Children's Hospital | N/A |
| Completed | PERSPECTIVE: Telithromycin - Acute Exacerbation of Chronic Bronchitis NCT00132938 | Sanofi | Phase 4 |
| Terminated | Evaluating Genes in Sputum to Measure Drug Response in COPD NCT00233051 | National Jewish Health | N/A |
| Completed | Yoga for Treating Shortness of Breath in Chronic Obstructive Pulmonary Disease (COPD) NCT00051792 | National Center for Complementary and Integrative Health (NCCIH) | Phase 1 / Phase 2 |
| Completed | Dietary and Genetic Factors in Asthma & Chronic Bronchitis in a Cohort of Chinese Singaporeans NCT00342030 | National Institute of Environmental Health Sciences (NIEHS) | — |
| Completed | Adherence to Guidelines for Antibiotic Use in Respiratory Infections at Hospitals NCT00129883 | Radboud University Medical Center | N/A |
| Completed | To Evaluate the Long-term Safety of (R,R)-Formoterol in Subjects With COPD NCT00064415 | Sumitomo Pharma America, Inc. | Phase 3 |
| Completed | Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD NCT00064402 | Sumitomo Pharma America, Inc. | Phase 3 |
| Completed | Inhaled Steroid Reduces Systemic Inflammation in COPD NCT00175565 | University of British Columbia | Phase 4 |
| Completed | A Study of the Effectiveness and Safety of High Dose, Short-course Levofloxacin in the Treatment of Acute Bact NCT00042718 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |
| Completed | Regulation of the Release of Inflammatory Mediators From Lung Macrophages. NCT00147017 | Imperial College London | — |
| Completed | Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD) NCT00147082 | Imperial College London | — |
| Recruiting | Emphysema Research Registry and Biosample Repository NCT00307281 | University of Pittsburgh | — |
| Completed | Study of Expectorant Activity of Oral N-acetylcystein (NAC) in Patients With Stable Chronic Bronchitis NCT00205647 | Wake Forest University | Phase 2 |