NCT01071161

The Effect of Azithromycin in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Chronic Productive Cough

Phase III (c) The Effect of Azithromycin in Patients With COPD and Chronic Productive Cough

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 84 (actual)
• Sponsor: Isala · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to demonstrate the efficacy of azithromycin to produce a significant change in the cough-related health status, measured with the Dutch version of the Leicester Cough Questionnaire in patiënts with COPD gold classification 2-4 and chronic productive coughing.

Detailed description

This study is a prospective double-centre, double blind randomised trial. Patients \> 40 years of age, referred to our outpatient clinic with chronic cough and sputum production due to COPD will be recruited after informed consent is obtained. Consenting patients will be randomises to a 12-week treatment with 250 mg azithromycin three times a week or placebo. Before randomisation all patients have to fill in the SF 36 , SGRQ and the Dutch version of the Leicester Cough Questionnaire (LCQ) for assessment of the baseline quality of life and the disease specific quality of life. The LCQ questionnaires will be performed at the beginning and every 3 weeks afterwards until 18 weeks, except the second LCQ which will be filled in after 2 weeks. Scores from this questionnaire will be used to calculate the 2-week repeatability. The SF 36 and SGRQ will be performed at the start of the study and after 12 weeks. Adverse events will be recorded during the whole treatment period. After 2 and 12 weeks a Global Rating of Change will be performed. This questionnaire will be used to validate the LCQ in COPD patients. Randomisation will take place using a computer allocation program (BAMI-computer) Azithromycin and placebo will be provided by Teva Pharmaceuticals. Placebo and azithromycin will be identical in appearance and packaging.

Conditions

• Cough
• Chronic Obstructive Pulmonary Disease
• Chronic Bronchitis

Interventions

Type	Name	Description
DRUG	azithromycin	azithromycin, tablets, during 12 weeks, three times a week, 250mg
DRUG	placebo	placebo

Timeline

• Start date: 2009-09-01
• Primary completion: 2012-02-01
• Completion: 2012-02-01
• First posted: 2010-02-19
• Last updated: 2015-09-18

Locations

1 site across 1 country: Netherlands