| Not Yet Recruiting | Clinical Genetics Branch Eligibility Screening Survey NCT07005297 | National Cancer Institute (NCI) | — |
| Recruiting | Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors NCT06625190 | University of Florida | Phase 1 / Phase 2 |
| Completed | Descriptive Cohort of French Patients Treated With Carbonetherapy Since October 2010 Outside PHRC-ETOILE NCT06535997 | Hospices Civils de Lyon | — |
| Active Not Recruiting | A Study of ERAS-601 in People With Chordoma NCT06957327 | Memorial Sloan Kettering Cancer Center | Phase 1 / Phase 2 |
| Active Not Recruiting | A Study of BL-B01D1 in Patients With Locally Advanced or Metastatic Chordoma NCT06787664 | Sichuan Baili Pharmaceutical Co., Ltd. | Phase 2 |
| Recruiting | Pembrolizumab and Pemetrexed for Progressive Chordoma NCT06794645 | Saint John's Cancer Institute | Phase 2 |
| Unknown | Apatinib Combined With Camrelizumab in Treating Participants With Advanced Chordoma NCT06140732 | Xuanwu Hospital, Beijing | Phase 2 |
| Recruiting | Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton Therapy NCT06029218 | Centre Antoine Lacassagne | N/A |
| Active Not Recruiting | Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors NCT05407441 | Susan Chi, MD | Phase 1 / Phase 2 |
| Recruiting | Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull Base NCT05861245 | Quironsalud | N/A |
| Active Not Recruiting | Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma NCT05041127 | M.D. Anderson Cancer Center | Phase 2 |
| Recruiting | Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone NCT05033288 | Mayo Clinic | — |
| Recruiting | Image Assisted Optimization of Proton Radiation Therapy in Chordomas and Chondrosarcomas NCT04832620 | Leiden University Medical Center | — |
| Completed | TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer NCT04246671 | Bavarian Nordic | Phase 1 |
| Completed | Immunohistochemical Study of Chordomas to Improve Their Diagnosis and Prognosis Care NCT04486820 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Completed | Pemetrexed for the Treatment of Chordoma NCT03955042 | Saint John's Cancer Institute | Phase 1 |
| Unknown | Anlotinib Hydrochloride Versus Imatinib Mesylate in Locally Advanced, Unresectable or Metastatic Chordoma NCT04042597 | Peking University People's Hospital | Phase 2 |
| Recruiting | Long-Term Longitudinal QoL in Patients Undergoing EEA NCT04087902 | Ohio State University | — |
| Recruiting | Children and Adults With Chordoma NCT03910465 | National Cancer Institute (NCI) | — |
| Completed | Nivolumab and Relatlimab in Treating Participants With Advanced Chordoma NCT03623854 | Jonsson Comprehensive Cancer Center | Phase 2 |
| Completed | BN Brachyury and Radiation in Chordoma NCT03595228 | Bavarian Nordic | Phase 2 |
| Withdrawn | QUILT-3.091 NANT Chordoma Vaccine vs Radiation in Subjects With Unresectable Chordoma. NCT03647423 | ImmunityBio, Inc. | Phase 1 / Phase 2 |
| Completed | Afatinib in Locally Advanced and Metastatic Chordoma NCT03083678 | Leiden University Medical Center | Phase 2 |
| Completed | CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma NCT03110744 | University Hospital Heidelberg | Phase 2 |
| Completed | Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers NCT03190174 | Sarcoma Oncology Research Center, LLC | Phase 1 / Phase 2 |
| Unknown | Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. NCT03242382 | Grupo Espanol de Investigacion en Sarcomas | Phase 2 |
| Recruiting | Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease NCT02986516 | Italian Sarcoma Group | N/A |
| Active Not Recruiting | Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent, Advanced, or Metastat NCT02989636 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 1 |
| Active Not Recruiting | Nivolumab and Ipilimumab in Treating Patients With Rare Tumors NCT02834013 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas NCT01567046 | Children's Oncology Group | — |
| Completed | A Study of IMRT in Primary Bone and Soft Tissue Sarcoma NCT02520128 | University College, London | N/A |
| Completed | QUILT-3.011 Phase 2 Yeast-Brachyury Vaccine Chordoma NCT02383498 | NantCell, Inc. | Phase 2 |
| Unknown | Study of Imatinib, a Platelet-derived Growth Factor Receptor Inhibitor, and LBH589, a Histone Deacetylase Inhi NCT01175109 | Deric M Park MD | Phase 1 |
| Completed | Nilotinib With Radiation for High Risk Chordoma NCT01407198 | Massachusetts General Hospital | Phase 1 |
| Unknown | Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base NCT01182779 | Heidelberg University | Phase 3 |
| Completed | Stereotactic Body Radiotherapy for Spine Tumors NCT01347307 | Mercy Research | N/A |
| Completed | Hypoxia-positron Emission Tomography (PET) and Intensity Modulated Proton Therapy (IMPT) Dose Painting in Pati NCT00713037 | Massachusetts General Hospital | N/A |
| Completed | Trial of Dasatinib in Advanced Sarcomas NCT00464620 | Sarcoma Alliance for Research through Collaboration | Phase 2 |
| Active Not Recruiting | Proton Beam Therapy for Chordoma Patients NCT00496119 | M.D. Anderson Cancer Center | Phase 2 |
| Unknown | Polyvinylpyrrolidone-Sodium Hyaluronate Gel in Reducing Pain From Oral Mucositis in Young Patients With Cancer NCT00349024 | Children's Cancer and Leukaemia Group | N/A |
| Completed | Efficacy and Safety of Imatinib in Chordoma NCT00150072 | Novartis Pharmaceuticals | Phase 2 |
| Completed | Chordoma Family Study NCT00410670 | National Cancer Institute (NCI) | — |
| Completed | Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine NCT00592748 | Massachusetts General Hospital | Phase 1 / Phase 2 |
| Completed | Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Sof NCT00919269 | Children's Oncology Group | — |
| Completed | Genetic Aspects of Chordoma: A Collaboration With SEER Registries to Identify Chordoma Families NCT00341627 | National Cancer Institute (NCI) | — |
| Terminated | Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors NCT00003926 | Masonic Cancer Center, University of Minnesota | Phase 1 |
| Available | BLESSED: Expanded Access for DNG64-CAR-V for Advanced Pancreatic Cancer, Sarcoma and Carcinoma of Breast NCT04091295 | Aveni Foundation | — |