NCT00592748

Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine

Randomized Study of Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 381 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better.

Detailed description

* Participants will be assigned to a dose level by random chance, like flipping a coin. * A treatment plan will be determined by a treatment planning CT scan and will either involve 40-44 treatments or 37-40 treatments.

Conditions

• Chordoma
• Chondrosarcoma

Interventions

Type	Name	Description
RADIATION	Charged Particle Radiation Therapy	Radiation doses will be determined by planning CT

Timeline

• Start date: 1999-06-01
• Primary completion: 2007-07-01
• Completion: 2015-05-01
• First posted: 2008-01-14
• Last updated: 2017-06-16

Locations

1 site across 1 country: United States