| Not Yet Recruiting | Phase 3 Bunionectomy Study NCT07490496 | Cali Pharmaceuticals LLC | Phase 3 |
| Completed | CPL-01 in the Management of Postoperative Pain After Bunionectomy NCT05831449 | Cali Pharmaceuticals LLC | Phase 3 |
| Unknown | Clinical Trial on Patient-Specific-Instrumentation Assisted Lapidus Fusion for Hallux Valgus NCT05602844 | Chinese University of Hong Kong | N/A |
| Completed | A Study to Evaluate Analgesic Efficacy and Safety of PRF-110 for Post-surgical Pain NCT05773846 | PainReform LTD | Phase 3 |
| Terminated | Early Weight-Bearing After the Lapiplasty Mini-Incision Procedure (Mini3D) NCT05082012 | Treace Medical Concepts, Inc. | N/A |
| Recruiting | LSTR in Chevron Osteotomy NCT06486753 | The Methodist Hospital Research Institute | N/A |
| Completed | Study to Evaluate the Safety and Tolerability of FX301 in Patients Undergoing Bunionectomy NCT04826328 | Pacira Pharmaceuticals, Inc | Phase 1 |
| Completed | Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl NCT04518462 | Pacira Pharmaceuticals, Inc | Phase 3 |
| Unknown | Liposomal Bupivacaine Versus Bupivacaine Plain for Operative Pain Management of Forefoot Surgery NCT04751344 | Alexandra Black | Phase 4 |
| Withdrawn | Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, an NCT03954639 | Pacira Pharmaceuticals, Inc | Phase 3 |
| Completed | Multi-Plane Hallux Valgus Correction With the Phantom® Nail NCT04084262 | Paragon 28 | — |
| Completed | Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety, of EXPAREL Administered as Sciatic Nerve NCT04002089 | Pacira Pharmaceuticals, Inc | Phase 1 |
| Active Not Recruiting | Early Weight-Bearing After the Lapiplasty Procedure NCT03740282 | Treace Medical Concepts, Inc. | N/A |
| Completed | Efficacy of Tranexamic Acid in Foot and Ankle Surgeries NCT03653429 | Icahn School of Medicine at Mount Sinai | Phase 4 |
| Terminated | Early Weight-Bearing After Lapidus Arthrodesis NCT03257540 | Paragon 28 | — |
| Completed | Study of Wafermine™ for Post-bunionectomy or Abdominoplasty Pain NCT03246971 | iX Biopharma Ltd. | Phase 2 |
| Terminated | Pericapsular Exparel for Pain Relief in Bunionectomy and Related Procedures NCT02499575 | OhioHealth | N/A |
| Completed | Mid-term Outcomes of First MTP Arthroplasty With Primus™ FGT Implant. NCT02350881 | Stryker Trauma and Extremities | — |
| Completed | Safety and Efficacy Study of COV155 for Post-operative Bunionectomy Pain NCT01743625 | Mallinckrodt | Phase 3 |
| Completed | Safety and Efficacy of COV795 in Moderate to Severe Post-Operative Bunionectomy Pain With an Open-label Extens NCT01484652 | Mallinckrodt | Phase 3 |
| Completed | Intravenous Tapentadol in Post-Bunionectomy Pain NCT01435577 | Grünenthal GmbH | Phase 2 |
| Terminated | Ketorolac Effects on Post-operative Pain and Bone Healing NCT01133639 | Beth Israel Deaconess Medical Center | N/A |
| Completed | Study of Postoperative Analgesia in Bunionectomy NCT00890682 | Pacira Pharmaceuticals, Inc | Phase 3 |
| Completed | A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain From Bu NCT00613938 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |
| Completed | A Study to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) in the Treatment of Acute Pain From Bun NCT00364247 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |