| Not Yet Recruiting | Sacituzumab Tirumotecan Plus Third-Generation TKI With/Without Radiotherapy for EGFR-Mutant NSCLC Brain Metast NCT07343479 | Zhejiang Cancer Hospital | Phase 2 |
| Not Yet Recruiting | A Phase II Clinical Study of Utidelone and Bevacizumab With or Without Etoposide in Patients With Brain Metast NCT07449481 | Tianjin Medical University Cancer Institute and Hospital | Phase 2 |
| Recruiting | Feasibility of a Cognitive Stepped Care Program for Adults With Brain Metastases NCT07355348 | University Health Network, Toronto | N/A |
| Not Yet Recruiting | Evaluation of Neoadjuvant Stereotactic Radiosurgery (SRS) and Multi-fraction SRS Alone for the Treatment of La NCT07329634 | Maciej Harat | Phase 3 |
| Withdrawn | Study of Lenvatinib Plus Pembrolizumab in IO Refractory mRCC Patients With Brain Metastases NCT07011849 | M.D. Anderson Cancer Center | Phase 2 |
| Not Yet Recruiting | Efficacy of the RayerKnife X Stereotactic Radiotherapy System in the Treatment of Brain Metastases NCT06852001 | Tianjin Medical University Cancer Institute and Hospital | N/A |
| Not Yet Recruiting | Sacituzumab Govitecan Combined With Head Radiotherapy for Her2-negative Breast Cancer Brain Metastases NCT06462079 | Guangzhou Medical University | Phase 2 |
| Recruiting | Elimination of PTV Margins Based on MRI-guided Adaptive Stereotactic Radiotherapy for Non-small Cell Lung Canc NCT06582940 | Sun Yat-sen University | Phase 2 |
| Not Yet Recruiting | SHR-A1921 Combined With Bevacizumab in Triple-negative Breast Cancer With Brain Metastases NCT06210438 | Fudan University | Phase 2 |
| Recruiting | 18F-FLUC PET/MR in Patients With Brain Mets NCT06159335 | University of Wisconsin, Madison | Phase 3 |
| Recruiting | Brain Metastasis Development Mechanism in BCBM Patients NCT06330870 | Samsung Medical Center | N/A |
| Recruiting | Stereotactic Radiotherapy in Oligometastatic Brain Disease: a Randomised Phase III Study Comparing Hypofractio NCT05102747 | Centre Francois Baclesse | N/A |
| Terminated | T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Br NCT03190967 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Unknown | PCI in Advanced Triple Negative Breast Cancer Patients Who Response to 1st Line Chemotherapy NCT02448576 | wang shusen | N/A |
| Terminated | Nivo/Ipi Combination Therapy in Symptomatic Brain Metastases NCT02621515 | University Medical Center Groningen | Phase 2 |
| Unknown | A Clinical Trial on Whole-brain Radiotherapy With Temozolomide Concurrent Chemotherapy or Avoidance of Hippoca NCT02832635 | Sun Yat-sen University | Phase 2 |
| Completed | Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung NCT02681549 | Yale University | Phase 2 |
| Withdrawn | NovoTTF-100A Therapy for Refractory CNS Involved Small Cell Lung Cancer NCT02425072 | John Villano | Phase 2 |
| Unknown | Neurocognitive Impact and Dose-Effect Relationship of Hippocampal Avoidance During Whole Brain Radiotherapy Pl NCT03223675 | Chang Gung Memorial Hospital | N/A |
| Terminated | Pharmacokinetics of Systemic Anti-Cancer Therapies in the Cerebrospinal Fluid (CSF) of Patients With Advanced NCT02580045 | Duke University | — |
| Recruiting | Hippocampal-Sparing Prophylactic Cranial Irradiation in Pathologically Nodal Positive Non-Small-Cell Lung Canc NCT02448992 | Chang Gung Memorial Hospital | Phase 2 / Phase 3 |
| Terminated | Methionine and PBR28-PET (Peripheral Benzodiazepine Receptors) in Brain Metastases Following Radiosurgery NCT02433171 | Yale University | — |
| Withdrawn | FLT PET/MR for Evaluation of Pseudoprogression in Patients With Brain Lesions NCT02328300 | UNC Lineberger Comprehensive Cancer Center | — |
| Completed | Hypofractionated Stereotactic Radiation Therapy of Brain Metastases: Evaluation of Whole-brain Radiotherapy NCT02913534 | Institut de Cancérologie de Lorraine | — |
| Completed | Study of SBRT Efficacy on Intra and Extra -Cranial Tumors or Metastasis in Pediatrics Population (SBRT Pediatr NCT02013297 | Centre Leon Berard | N/A |
| Withdrawn | Evaluation of Cabazitaxel in Patients With Brain Metastasis Secondary to Breast Cancer and NSCLC NCT01913067 | Jules Bordet Institute | Phase 2 |
| Unknown | VEGFRs Predict Bevacizumab Benefit in Advanced Non Small Cell Lung Cancer NCT01891708 | Li Liu | — |
| Completed | Evaluation of the Efficacy of Hippocampal Avoidance on the Cognitive Toxicity of Whole-Brain Radiation Therapy NCT01942980 | Institut Paoli-Calmettes | Phase 3 |
| Recruiting | A Prospective Study of the Impact of Hippocampal Avoidance During Whole Brain Radiotherapy on Neurocognitive F NCT02504788 | Chang Gung Memorial Hospital | N/A |
| Completed | Icotinib or Whole Brain Irradiation in EGFR-mutant Lung Cancer NCT01724801 | Guangdong Association of Clinical Trials | Phase 3 |
| Completed | Ipilimumab Combined With a Stereotactic Radiosurgery in Melanoma Patients With Brain Metastases NCT02662725 | University Hospital, Lille | Phase 2 |
| Terminated | Vorinostat and Concurrent Whole Brain Radiotherapy for Brain Metastasis NCT01600742 | National Taiwan University Hospital | Phase 2 |
| Terminated | Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors NCT01324635 | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | Phase 1 |
| Terminated | Pilot Study of Vardenafil and Carboplatin in Patients With Gliomas and Brain Metastases NCT02279992 | Cedars-Sinai Medical Center | EARLY_Phase 1 |
| Terminated | Assess the Efficacy of Whole Brain Radiation Therapy in Lung Cancer Patients With Brain Metastasis NCT01363557 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Phase I Trial of Stereotactic Radiosurgery Following Surgical Resection of Brain Metastases NCT01395407 | Emory University | Phase 1 |
| Completed | Evaluation of the Use of Trental and Vitamin E For Prophylaxis of Radiation Necrosis NCT01508221 | University of Cincinnati | Phase 2 |
| Terminated | Study of Whole-brain Irradiation With Chloroquine for Brain Metastases NCT01894633 | Instituto Nacional de Cancerologia de Mexico | Phase 2 |
| Completed | Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases NCT01445483 | National Cancer Institute (NCI) | — |
| Completed | IDO2 Genetic Status Informs the Neoadjuvant Efficacy of Chloroquine (CQ) in Brain Metastasis Radiotherapy NCT01727531 | Main Line Health | N/A |
| Unknown | Efficacy of Gefitinib for Brain Metastasis of Non-Small Cell Lung Cancer NCT00614809 | Guangdong Provincial People's Hospital | Phase 2 |
| Completed | Study of Patupilone in Patients With Brain Metastasis From Non-small Cell Lung Cancer NCT00219297 | Novartis Pharmaceuticals | Phase 2 |
| Completed | Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases NCT00587964 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Completed | Prospective Randomized Trial Between WBRT Plus SRS Versus SRS Alone for 1-4 Brain Metastases NCT00406835 | Hokkaido University Hospital | — |