NCT00406835

Prospective Randomized Trial Between WBRT Plus SRS Versus SRS Alone for 1-4 Brain Metastases

Phase 3 Study of Whole Brain Radiation Therapy Plus Stereotactic Radiosurgery Versus Stereotactic Radiosurgery Alone for 1-4 Brain Metastases

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 180 (planned)
• Sponsor: Hokkaido University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if WBRT combined with SRS resulted in improvements in survival, brain tumor control, functional preservation rate, and frequency of neurologic death.

Detailed description

Whole-Brain Radiation Therapy (WBRT) had been a mainstay in the treatment of brain metastases. However, treatment strategy which rely on Stereotactic Radiosurgery (SRS) has becoming popular in Japan. It is not well understood if the Whole-Brain Radiation Therapy (WBRT) combined with Stereotactic Radiosurgery (SRS) resulted in improvements in survival, brain tumor control, functional preservation rate, and frequency of neurologic death. In orer to determine the role of WBRT, we conducted prospective randomized trial between WBRT+SRS and SRS-alone for 1-4 brain metastatic patients.

Conditions

• Brain Metastasis

Interventions

Type	Name	Description
PROCEDURE	Whole-Brain Radiation Therapy, Stereotactic Radiosurgery

Timeline

• Start date: 1999-10-01
• Completion: 2005-04-01
• First posted: 2006-12-04
• Last updated: 2006-12-04

Locations

1 site across 1 country: Japan