| Not Yet Recruiting | The Effect of Caffeine Therapy in Cardiovascular Stability in Preterm Neonates at Assiut University Children H NCT07274969 | Assiut University | — |
| Not Yet Recruiting | Caffeine Citrate in Preterm Infants at Risk of Apnea in Zambia NCT06518603 | University of Alabama at Birmingham | Phase 4 |
| Not Yet Recruiting | The Role of Electroencephalography in Caffeine Discontinuation Timing in Premature Infants NCT07324941 | Uludag University | — |
| Not Yet Recruiting | Caffeine Citrate to Improve Neonatal Outcomes. NCT06972849 | University of Melbourne | N/A |
| Recruiting | "Prapela® SVS Incubator Pad for Apnea of Prematurity NCT06374147 | Tufts Medical Center | N/A |
| Recruiting | Efficacy of PIMUN by Reducing Intermittent Hypoxia Events NCT07396103 | Pontificia Universidad Catolica de Chile | N/A |
| Active Not Recruiting | Apnea of Prematurity Results in Respiratory Distress and Cyanosis. Caffeine Citrate Can Treat It. NCT06905496 | Nishtar Medical University | Phase 1 |
| Recruiting | The PARS Study: Paediatric Advanced Respiratory Service Study - An Observational Diagnostic Feasibility Study NCT06292299 | NHS Greater Clyde and Glasgow | — |
| Active Not Recruiting | Caffeine Use in the Management of Preterm Infants NCT06327152 | University of California, Irvine | Phase 2 |
| Recruiting | The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate NCT06401083 | Semmelweis University | Phase 4 |
| Completed | Non-Invasive Neurally Adjusted Ventilatory Assist (NAVA) Prone vs Supine in Premature Infants NCT05968586 | Milton S. Hershey Medical Center | N/A |
| Completed | Nasal Olfactory Stimulation and Its Effect on Respiratory Drive in Preterm Infants NCT05878925 | University of Zurich | N/A |
| Active Not Recruiting | Detection of CardioRespiratory Events Using Acoustic Monitoring in Preterm Infants on CPAP NCT05196646 | McGill University Health Centre/Research Institute of the McGill University Health Centre | — |
| Completed | Pilot Study to Evaluate Doses of Mechanical Stimulus on the Effectiveness of Preterm Breathing NCT06639581 | Pontificia Universidad Catolica de Chile | N/A |
| Recruiting | The Effect of Womb Recordings on Maturation of Respiratory Control in Preterm Infants NCT05298748 | Case Western Reserve University | N/A |
| Completed | Caffeine Citrate Use and Electronic Activity of the Diaphragm (EDI) Changes NCT05393817 | Seoul St. Mary's Hospital | — |
| Completed | Target Weaning Oxygen to Determine Cafffeine Duration for AOP NCT04868565 | Children's Hospital of Chongqing Medical University | Phase 4 |
| Recruiting | Doxapram Therapy in Preterm Infants (DOXA Trial) NCT04430790 | Erasmus Medical Center | Phase 3 |
| Completed | Effect of High Frequency Oscillatory Highflow Nasal Cannula on Desaturations and Bradycardia in Preterm Infant NCT04327466 | University of Zurich | N/A |
| Completed | Apnea Treatment in Premature Infants Using an Automatic Vibro-tactile Stimulator Triggered by the Detection of NCT03651648 | Rennes University Hospital | N/A |
| Unknown | Caffeine as Respiratory Stimulant in Preterm Infants NCT04144712 | Ain Shams University | Phase 1 |
| Terminated | Moderately Preterm Infants With Caffeine at Home for Apnea (MoCHA) Trial NCT03340727 | NICHD Neonatal Research Network | Phase 3 |
| Completed | Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants NCT03695900 | University of Miami | N/A |
| Completed | The Effect of Standardizing the Definition of a Clinically Significant Cardiopulmonary Event on Length of Stay NCT03414671 | Pediatrix | — |
| Completed | Hemodynamic Responses to Cardio-respiratory Events in Preterm Infants NCT04184245 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Completed | Cardio-respiratory Events in Preterm Infants During Transition NCT04123691 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Completed | A Comparison of Non-invasive Ventilation Methods Used to Prevent Endotracheal Intubation Due to Apnea in Very NCT03298035 | The University of Texas Health Science Center, Houston | N/A |
| Unknown | Caffeine for Preterm Infants With Apnea of Prematurity(AOP) NCT03298347 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | N/A |
| Terminated | CPAP vs.Unsynchronized NIPPV at Equal Mean Airway Pressure NCT03670732 | Women and Infants Hospital of Rhode Island | N/A |
| Completed | A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation NCT03292562 | The University of Texas Health Science Center, Houston | N/A |
| Unknown | Early Caffeine in Preterm Neonates NCT03086473 | Jennifer Shepherd | Phase 4 |
| Completed | NIV-NAVA Versus Nasal Continuous Positive Airway Pressure (nCPAP) or Non Synchronized NIPPV NCT02860325 | Complejo Hospitalario Universitario Insular Materno Infantil | N/A |
| Terminated | Early Versus Late Caffeine for ELBW Newborns NCT02524249 | Wayne State University | N/A |
| Unknown | Influence of Oxygen Target Range on Intermittent Hypoxemia in Preterm Infants NCT02743988 | University of Ulm | N/A |
| Completed | Effect of Caffeine on Preterm Infants' Bone Mineral Content NCT03084432 | Ain Shams University | — |
| Completed | Effect of Feedings on Caffeine in Premature Infants NCT02293824 | Duke University | — |
| Completed | Non-invasive Intervention for Apnea of Prematurity NCT02641249 | University of California, Los Angeles | N/A |
| Completed | Effect of Three-Stair-Position on Improvement of Apnea of Prematurity NCT02346864 | Children's Hospital of Fudan University | N/A |
| Completed | Stochastic Resonance Mattress (Physiological Interventions) and Biomarkers for Enhancing Neonatal Health NCT01643057 | Wyss Institute at Harvard University | — |
| Terminated | Inhalation of Low Concentration of CO2 in Preterm Infants Not Responding to Caffeine for the Treatment of Apne NCT01911182 | University of Manitoba | Phase 2 / Phase 3 |
| Completed | Clinical Study of Caffeine for Apnea of Prematurity NCT01408173 | Nobelpharma | Phase 3 |
| Completed | Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study NCT01020357 | McMaster University | Phase 3 |
| Completed | MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine NCT00809055 | Washington University School of Medicine | Phase 4 |
| Terminated | A Trial of Infant Flow Biphasic Nasal Continuous Airway Pressure (NCPAP) Versus Infant Flow NCPAP for the Faci NCT00308789 | Mount Sinai Hospital, Canada | Phase 2 |
| Completed | Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study NCT00296231 | Tarah T Colaizy | Phase 1 |
| Terminated | Use of Sucrose to Relieve Pain During Eye Exams in Infants NCT00161694 | Weill Medical College of Cornell University | N/A |
| Terminated | Randomized Trial Investigating Four Nasal CPAP Systems in the Management of Apnea of Prematurity NCT00482040 | University Hospital Tuebingen | N/A |
| Completed | CO2 Inhalation as a New Treatment Modality for Apnea of Prematurity NCT01066728 | University of Manitoba | Phase 2 / Phase 3 |
| Completed | Caffeine for Apnea of Prematurity (CAP) NCT00182312 | McMaster University | Phase 3 |