| Recruiting | ART Trial: Transcatheter J-VALVE Versus Surgery for Aortic Regurgitation Therapy NCT07453407 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Not Yet Recruiting | Comparison of Early Postoperative Outcomes Between Minimally Invasive Valve Surgery Via Right Thoracotomy and NCT07251660 | Chaudhry Pervaiz Elahi Institute of Cardiology | N/A |
| Not Yet Recruiting | Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice NCT07068633 | Yonsei University | — |
| Recruiting | ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™ NCT06608823 | JenaValve Technology, Inc. | N/A |
| Recruiting | The JenaValve ALIGN-AR LVAD Registry NCT06594705 | JenaValve Technology, Inc. | N/A |
| Recruiting | European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study NCT06235385 | Assistance Publique - Hôpitaux de Paris | — |
| Active Not Recruiting | Proximal Aortopathy in Scotland - Epidemiology and Surgical Outcomes NCT05389865 | Golden Jubilee National Hospital | — |
| Terminated | Evaluation of ARi With OpSens SavvyWire NCT06295068 | Opsens, Inc. | — |
| Recruiting | ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosth NCT05172973 | Edwards Lifesciences | N/A |
| Active Not Recruiting | Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR NCT05295628 | Emblok, Inc. | N/A |
| Active Not Recruiting | J-Valve TF Early Feasibility Study NCT06034028 | JC Medical, Inc., an affiliate of Edwards Lifesciences LLC | N/A |
| Enrolling By Invitation | CT-evaluation of Coronary Ostia Height After Surgical Aortic Valve Replacement. NCT05714293 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Completed | Aortic or Mitral Valve Replacement With the Braile Biomédica® Bovine Pericardium Valvular Bioprosthesis NCT05902897 | Braile Biomedica Ind. Com. e Repr. Ltda. | — |
| Unknown | Prevalence Study of Cardiovascular Diseases in a Population ≥ 65 Years in Italy NCT05892588 | Azienda Ospedaliero-Universitaria Careggi | — |
| Unknown | Open Label RCT for Chronic Severe AR : Entresto vs. CCB/ARB NCT05212597 | Samsung Medical Center | Phase 2 |
| Unknown | Clinical Investigation for the Foldax Tria Aortic Heart Valve- India NCT06192706 | Foldax, Inc | N/A |
| Completed | Effect of Anesthetics on Troponin I and С-reactive Protein NCT05742789 | Astana Medical University | Phase 1 |
| Completed | Short-term Clinical Follow-up of the Vascular Closure Device MANTATM in Minimally Invasive Cardiac Surgery NCT04802200 | Centre Hospitalier Universitaire Dijon | — |
| Completed | The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery NCT05695287 | Astana Medical University | Phase 1 |
| Terminated | HAART Annuloplasty Device Valve Repair Registry NCT04035356 | Biostable Science & Engineering | — |
| Recruiting | Avalus European Registry - an Observational Study to Evaluate Safety and Efficacy in a Real World Population NCT05572710 | Universitaire Ziekenhuizen KU Leuven | — |
| Active Not Recruiting | The JenaValve ALIGN-AR Pivotal Trial NCT04415047 | JenaValve Technology, Inc. | N/A |
| Recruiting | Results of the Aortic Valve Reconstruction in Children NCT04162444 | National Medical Research Center for Children's Health, Russian Federation | — |
| Completed | Influence of Anesthetics on Clinical Outcome in Mitral and Aortic Valve Replacement in Adults NCT05696509 | Astana Medical University | Phase 3 |
| Unknown | Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes NCT03728049 | University Hospital, Lille | N/A |
| Active Not Recruiting | Assessment of Paravalvular Leak After TAVI by Hemodynamic Measurements and Cardiac MRI NCT04281771 | Radboud University Medical Center | N/A |
| Recruiting | Transpacific TAVR Registry NCT03826264 | Duk-Woo Park, MD | — |
| Unknown | Online Videodensitometric Assessment of Aortic Regurgitation in the Cath-Lab NCT04047082 | Imperial College London | — |
| Completed | Anticoagulation for Aortic Bioprosthesis (ANTIPRO) NCT03807921 | Instituto Nacional de Cirugia Cardiaca, Uruguay | Phase 4 |
| Active Not Recruiting | Identification of Genetic Causes of Calcific Aortic Valve Disease NCT04149600 | Beth Israel Deaconess Medical Center | — |
| Terminated | Evaluation of Effectiveness and Safety of Evolut R Valve In Patients With Pure Aortic Regurgitation NCT03578952 | Seung-Jung Park | N/A |
| Unknown | Polish Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI) Registry NCT03361046 | Medical University of Warsaw | — |
| Completed | Protocoled Quantitative Assessment of Aortic Regurgitation Using Videodensitometry in a Multicontinental Trial NCT03644784 | Imperial College London | — |
| Unknown | China Valve Registry Study-1 NCT02623907 | Shanghai Zhongshan Hospital | — |
| Terminated | Mitroflow DL Post Approval Study- North America NCT02351726 | LivaNova | N/A |
| Unknown | Pilot Trial: Comparison of Flow Patterns NCT02288871 | Medical University of Vienna | N/A |
| Completed | Enable® Aortic Sutureless Bioprosthesis Evaluation NCT01720342 | Medtronic Cardiac Rhythm and Heart Failure | — |
| Active Not Recruiting | ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New T NCT01757665 | Edwards Lifesciences | N/A |
| Terminated | Enable I Long-term Follow-up Study NCT01636648 | Medtronic Cardiac Rhythm and Heart Failure | — |
| Completed | Trifecta™ Long Term Follow-Up (LTFU) Study NCT01593917 | Abbott Medical Devices | — |
| Completed | Clinical Trial of the Edwards Aortic Bioprosthesis, Model 11000 NCT01651052 | Edwards Lifesciences | N/A |
| Completed | Study of Aortic Root Reimplantation Procedure NCT01787604 | Meshalkin Research Institute of Pathology of Circulation | N/A |
| Completed | Effect of Beta Blockade on Left Ventricular Remodeling and Function in Moderate to Severe Asymptomatic Aortic NCT01157572 | Oslo University Hospital | Phase 4 |
| Completed | Biomarkers in Aortic Stenosis - B.A.S.S. NCT01334801 | Mayo Clinic | — |
| Terminated | German Aortic Valve Registry NCT01165827 | German Aortic Valve Registry | — |
| Unknown | The Italian Society of Invasive Cardiology Registry on Percutaneous Aortic Valve NCT02713932 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Completed | CryoValve® SG Aortic Human Heart Valve Combination Study NCT01236469 | CryoLife, Inc. | — |
| Completed | CryoValve SG Pulmonary Human Heart Valve Post Clearance Study NCT01092442 | CryoLife, Inc. | — |
| Unknown | Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Su NCT01201070 | University of Bari | Phase 4 |
| Completed | German TAVI-Register NCT02815514 | Stiftung Institut fuer Herzinfarktforschung | — |
| Completed | An Observational, Prospective Evaluation of the Trifecta™ Valve NCT00727181 | Abbott Medical Devices | N/A |
| Completed | Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX NCT01171625 | Edwards Lifesciences | N/A |
| Completed | Aortic Valve Replacement With Trifecta(TM) NCT00475709 | Abbott Medical Devices | N/A |
| Completed | Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root. CAVIAAR NCT00478803 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | Aortic Valve Replacement With Trifecta(TM) NCT00475267 | Abbott Medical Devices | N/A |
| Completed | Aortic or Mitral Valve Replacement With the Biocor and Biocor Supra NCT00636987 | Abbott Medical Devices | N/A |
| Enrolling By Invitation | Outcomes of Aortic Dissection Repair NCT05927090 | Centre Cardiologique du Nord | — |
| Completed | Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery NCT00082121 | Avant Immunotherapeutics | Phase 2 |
| Terminated | Echocardiographic Assessment of Cardiovascular Changes in Long Term Space Flight NCT00598598 | The Cleveland Clinic | — |
| Terminated | Three Dimensional Imaging and Wireless Technologies to Enhance Medical Care in Space NCT00598767 | The Cleveland Clinic | — |
| Withdrawn | Diagnostic Three Dimensional Echocardiography Study Protocol NCT00598754 | The Cleveland Clinic | — |
| Completed | Investigation of Heart Function in Patients With Heart Valve Defects NCT00001314 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Unknown | Aortic Regurgitation After Surgical Repair of Outlet-Type Ventricular Septal Defect NCT00173186 | National Taiwan University Hospital | — |
| No Longer Available | J-Valve Compassionate Use NCT03876964 | JC Medical, Inc., an affiliate of Edwards Lifesciences LLC | — |