| Recruiting | DELINEATE-Prospective NCT07197736 | Columbia University | — |
| Not Yet Recruiting | TAVR for Aortic Regurgitation Under TTE Guidance NCT07458672 | Chinese Academy of Medical Sciences, Fuwai Hospital | N/A |
| Recruiting | ART Trial: Transcatheter J-VALVE Versus Surgery for Aortic Regurgitation Therapy NCT07453407 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Not Yet Recruiting | TAVR for Aortic Regurgitation Under TEE Guidance NCT07453849 | Chinese Academy of Medical Sciences, Fuwai Hospital | N/A |
| Not Yet Recruiting | Mild and Moderate Aortic Regurgitation: Risk Factors for Progress and Outcome NCT07104968 | Uppsala University | — |
| Enrolling By Invitation | 3-Dimensional Simulation Guided Transcatheter Aortic Valve Replacement in Aortic Regurgitation(DIGITAL) NCT07398911 | Xijing Hospital | N/A |
| Recruiting | Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve NCT07097740 | Mitrassist Lifesciences Limited Co., Ltd. | N/A |
| Recruiting | ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™ NCT06608823 | JenaValve Technology, Inc. | N/A |
| Recruiting | TRanscAtheter TreatMent of PurE Aortic Regurgitation With VitaFlow Liberty System NCT06818084 | Ruijin Hospital | Phase 4 |
| Recruiting | Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease NCT06780241 | The Cleveland Clinic | — |
| Recruiting | The JenaValve ALIGN-AR LVAD Registry NCT06594705 | JenaValve Technology, Inc. | N/A |
| Active Not Recruiting | J-Valve TF Early Feasibility Study NCT06034028 | JC Medical, Inc., an affiliate of Edwards Lifesciences LLC | N/A |
| Recruiting | Safety and Effectiveness of TaurusTrio™ Heart Valve System in Patients With Severe Aortic Regurgitation (AR) NCT06101888 | Peijia Medical Technology (Suzhou) Co., Ltd. | N/A |
| Enrolling By Invitation | CT-evaluation of Coronary Ostia Height After Surgical Aortic Valve Replacement. NCT05714293 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Unknown | TAVR in Adults With Pure Severe Aortic Regurgitation NCT05737264 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Withdrawn | HLT® Meridian® TAVR Valve System Early Feasibility Study for Aortic Regurgitation NCT05409378 | HLT Inc. | N/A |
| Unknown | Performance of Currently Available traNscaTHEter Aortic Valve Platforms in Inoperable Patients With Pure Aorti NCT05319171 | IRCCS Policlinico S. Donato | — |
| Completed | Fate of Moderate Secondary Mitral Regurgitation in Patients Undergoing Aortic Valve Surgery for Severe Aortic NCT05774808 | Michele De Bonis | — |
| Completed | Aortic Valve-sparing Root Replacement, According to the Inclusion Technique Described by Tirone David NCT05515848 | Nantes University Hospital | — |
| Completed | LOng-Term Fate of Moderate Aortic Regurgitation Left Untreated at the Time of Mitral Valve Surgery NCT05774795 | Michele De Bonis | — |
| Active Not Recruiting | The JenaValve ALIGN-AR Pivotal Trial NCT04415047 | JenaValve Technology, Inc. | N/A |
| Recruiting | Comparative Imaging Assessment of Valvular Heart Disease NCT04126018 | The Cleveland Clinic | — |
| Unknown | Evaluate the Transcatheter Artificial Aortic Valve and Transcatheter Artificial Heart Values Delivery System NCT03788590 | Ningbo Jenscare Biotechnology Co., Ltd. | N/A |
| Completed | Study to Evaluate the Effect on Improvement of LVH by the Control of BP in Hypertension Patients With AV Disea NCT03666351 | Hanmi Pharmaceutical Company Limited | Phase 4 |
| Terminated | Evaluation of Effectiveness and Safety of Evolut R Valve In Patients With Pure Aortic Regurgitation NCT03578952 | Seung-Jung Park | N/A |
| Unknown | Transcatheter Aortic Valve Replacement With Extracorporeal Life System Support NCT04160624 | Xijing Hospital | N/A |
| Completed | China S3: Safety and Effectiveness of Edwards Lifesciences SAPIEN 3 THV in the Chinese Population NCT03466918 | Edwards Lifesciences | N/A |
| Unknown | Accuracy of Left Subclavian Regurgitation Evaluated by Ultrasound Doppler and 4D Flow MRI NCT03549091 | Fondation Hôpital Saint-Joseph | N/A |
| Active Not Recruiting | THE ALIGN-AR EFS TRIAL: JenaValve Pericardial TAVR Aortic Regurgitation Study NCT02732704 | JenaValve Technology, Inc. | N/A |
| Unknown | Expiratory Flow Limitation and Mechanical Ventilation During Cardiopulmonary Bypass in Cardiac Surgery NCT02633423 | Ospedale San Raffaele | N/A |
| Completed | China XT: Safety and Effectiveness of Edwards Lifesciences SAPIEN XT THV in the Chinese Population NCT03314857 | Edwards Lifesciences | N/A |
| Active Not Recruiting | Transcatheter Aortic Valve Replacement Versu Surgical Aortix Valve Replacement for Treating Elderly Patients W NCT03383445 | Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | N/A |
| Unknown | Rivaroxaban or Aspirin for Biological Aortic Prosthesis NCT02974920 | Christian Torp-Pedersen | Phase 4 |
| Completed | Cardiac T1 Mapping Enables Risk Prediction of LV Dysfunction After Surgery for Aortic Regurgitation NCT05332184 | Universitätsklinikum Hamburg-Eppendorf | — |
| Terminated | Mitroflow DL Post Approval Study- North America NCT02351726 | LivaNova | N/A |
| Completed | Investigation of Patients With BAV Requiring Valve and/or Aortic Repair (GISSI Outliers VAR) NCT02283970 | Gruppo di Ricerca GISSI | — |
| Completed | JUPITER Study: Transapical Aortic Valve Implantation for Aortic Regurgitation NCT01598844 | JenaValve Technology, Inc. | — |
| Completed | HAART Model 300 Annuloplasty Ring NCT01400841 | Biostable Science & Engineering | N/A |
| Unknown | Comparison Study of Echocardiography and Cardiovascular Magnetic Resonance Imaging in the Assessment of Mitral NCT04038879 | Atlantic Health System | — |
| Completed | Velocity Vector Imaging in Patients With Moderate-to-Severe Aortic Regurgitation NCT00624884 | Florence Nightingale Hospital, Istanbul | — |
| Completed | The Fate of Aortic Valve After SAS Surgery in Children NCT06751368 | Chinese Academy of Medical Sciences, Fuwai Hospital | — |
| Completed | Diastolic Dysfunction in Aortic Regurgitation NCT00976625 | University of Bern | N/A |