NCT00976625

Diastolic Dysfunction in Aortic Regurgitation

Persistent Diastolic Dysfunction Late After Valve Replacement in Severe Aortic Regurgitation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: University of Bern · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Follow-up study in patients with severe aortic regurgitation after successful valve replacement. Systolic and diastolic function were assessed and persistent diastolic dysfunction was observed late (7-10 years) after operation.

Detailed description

Background Patients with severe aortic regurgitation show eccentric LV hypertrophy and structural changes of the myocardium. Reversibility of functional and structural changes after successful valve replacement may be limited. Persistent diastolic dysfunction has been observed in the present study late after aortic valve replacement. This finding has been explained by incomplete regression of the extra-cellular matrix 7 years after valve replacement. Interstitial fibrosis remains unchanged compared to the preoperative situation but was increased early after operation due to the reduction in LV muscle mass. Regression of LV hypertrophy was 40% after 2 and 55% after 7 years of valve replacement. Myocardial muscle fibers decreased slightly but remained hypertrophied even late after operation. Interstitital fibrosis was found to be positively correlated to myocardial stiffness and inversely to LV ejection fraction. Thus, persistent diastolic dysfunction with maintained systolic ejection performance can be observed late after successful valve replacement in patients with severe aortic regurgitation. Altered diastolic function has been associated with increased filling pressures during strenuous exercise with signs of dyspnea. Objective Evaluation of myocardial structure and function in patients with chronic volume overload before and after valve replacement(LV-remodeling). Methods Pressure-volume measurements and myocardial biopsy samples for assessing myocardial function and structure.

Conditions

• Aortic Regurgitation

Interventions

Type	Name	Description
PROCEDURE	Aortic Valve Replacement	Surgical valve replacement of the aorta

Timeline

• Start date: 1996-01-01
• Primary completion: 2006-12-01
• Completion: 2007-12-01
• First posted: 2009-09-14
• Last updated: 2009-09-14

Locations

1 site across 1 country: Switzerland