| Not Yet Recruiting | Are Clinical Outcomes Unchanged by ALL Fixation at 0° or 30° of Knee Flexion in Combined ACL-ALL Reconstructio NCT07451743 | ASL Lecce | N/A |
| Recruiting | ACL Reconstruction With Shark Screw® or Biocomposite-interference Screws NCT06357091 | Alexander Rofner-Moretti | N/A |
| Recruiting | Investigation of the Effects of Proprioceptive Exercises After Anterior Cruciate Ligament Surgery NCT07333092 | Uskudar University | N/A |
| Recruiting | Cross Bracing Protocol Versus Surgery for Acute Anterior Cruciate Ligament Rupture NCT06956339 | University of Melbourne | N/A |
| Recruiting | Effect of the Hockey Slideboard Training Combined With Blood Flow Restriction (BFR) in the Rehabilitation Foll NCT06955026 | Spitalul Municipal Odorheiu Secuiesc | N/A |
| Completed | Early Treatment Based Neuroscience Education in Knee NCT05440890 | University of Malaga | N/A |
| Recruiting | Vitamin D to Improve Quadricep Muscle Strength NCT05174611 | Chinese University of Hong Kong | Phase 2 |
| Recruiting | Assessing the Efficacy of a Preoperative Navigation System in Anterior Cruciate Ligament Reconstruction NCT06858930 | Beijing Tsinghua Chang Gung Hospital | N/A |
| Active Not Recruiting | The Comparison of Tunnel Morphology and Graft Healing in Anterior Cruciate Ligament Reconstructions Using Pero NCT06769711 | Karadeniz Technical University | N/A |
| Not Yet Recruiting | Benefits of Ballistic Tests After the Anterior Cruciate Ligament Surgery NCT06720649 | Almaviva Sante | N/A |
| Recruiting | Effect of Preoperative Exercise Habits on Knee Function and Recurrence Rate After Anterior Cruciate Ligament R NCT06608394 | Peking University Third Hospital | — |
| Enrolling By Invitation | Obtain Safety and Effectiveness of CT-ACL001, a Regenerative Ligament Using Biological Tissue, in ACLR NCT07129694 | CoreTissue BioEngineering Inc. | N/A |
| Recruiting | Over-the-Top vs. Anteromedial ACLR With Lateral Extraarticular Tenodesis NCT06664047 | Ankara City Hospital Bilkent | N/A |
| Recruiting | Comparison of Clinical Outcomes Between All-Inside and Complete Tibial Tunnel Techniques in Anterior Cruciate NCT07023653 | Indonesia University | N/A |
| Recruiting | A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (AC NCT06979804 | Illinois Center for Orthopaedic Research and Education | N/A |
| Recruiting | Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction NCT06511232 | The Methodist Hospital Research Institute | Phase 4 |
| Active Not Recruiting | Utilization of a 3D Printed Customized Knee Extender and At-Home Rehabilitation Program on Patient Outcomes Fo NCT06524349 | Sanford Health | N/A |
| Not Yet Recruiting | Mg Wire for Augmentation of ACL Reconstruction NCT05983692 | Chinese University of Hong Kong | N/A |
| Recruiting | Comparison of Two Different Rehabilitation Approaches Applied After Anterior Cruciate Ligament Reconstruction NCT06831279 | Marmara University | N/A |
| Recruiting | Stopping OsteoARthritis After an ACL Tear NCT06195423 | University of British Columbia | N/A |
| Recruiting | Return to Play After ACL Reconstruction With Bone Marrow Aspirate, DBM, and an Internal Brace NCT06294314 | Marshall University | — |
| Recruiting | Anterior Cruciate Ligament (ACL) Revision Surgery: French National Study NCT06379308 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Unknown | Isoinertial Rehabilitation in Recovering Hamstring Strength Following Surgical Anterior Cruciate Ligament Reco NCT06063915 | Università degli studi di Roma Foro Italico | N/A |
| Enrolling By Invitation | The Clinical Efficacy of Anterolateral Complex Augmentation in Patients With ACL Rupture Combined With Excessi NCT06961292 | Peking University Third Hospital | — |
| Enrolling By Invitation | Reconstruction of the ACL With QT Graft With Bone Plug vs BPTB NCT06189573 | Instituto Nacional de Rehabilitacion | N/A |
| Recruiting | Anterior Cruciate Ligament Study NCT06194682 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Recruiting | Anterior Cruciate Ligament Reconstruction With a Periosteal - Patellar Tendon - Bone Autograft - The Kocabey P NCT06190223 | Ankara City Hospital Bilkent | — |
| Recruiting | Exploring Prolonged AMR in ACL Reconstructed Patients NCT06430775 | University Ghent | — |
| Not Yet Recruiting | FNB in ACL Recon Under GA NCT06048848 | Chuncheon Sacred Heart Hospital | N/A |
| Not Yet Recruiting | FNB in ACL Recon Under SA NCT06048874 | Chuncheon Sacred Heart Hospital | N/A |
| Withdrawn | Bilateral Versus Unilateral Strength Training After ACLR NCT06032247 | University of Kansas | N/A |
| Recruiting | Effects of Preoperative Rehabilitation on Tendon Healing, Bone Mineral Density, and Cartilage After ACLR and P NCT05924178 | Peking University Third Hospital | N/A |
| Terminated | Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention Following an Acute Knee NCT05204836 | University of Calgary | Phase 1 |
| Completed | Arthrometry and Clinical Tests for Diagnosing ACL Tears NCT05416632 | Liverpool University Hospitals NHS Foundation Trust | N/A |
| Completed | Arthroscopic ACL Reconstruction: Quadriceps Tendon vs Hamstring Tendon Autograft - A Prospective RCT NCT07470944 | Sawai Mansingh Medical College | N/A |
| Recruiting | Optimized Rehabilitation After Anterior Cruciate Ligament Before Returning to Sport NCT05323474 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Unknown | BTB Graft Harvest and Donor Site Morbidity After ACL Reconstruction NCT06030791 | Clinical Center of Vojvodina | — |
| Completed | Functional Connectivity After Anterior Cruciate Ligament Reconstruction NCT05487768 | University Hospital, Ghent | N/A |
| Completed | Blood Flow Restriction After Anterior Cruciate Ligament Reconstruction (ACLR) NCT05500872 | Hacettepe University | N/A |
| Completed | The PreOperative Management of Patients Awaiting Anterior Cruciate Ligament Reconstruction NCT05529511 | University Hospitals of Derby and Burton NHS Foundation Trust | — |
| Recruiting | Combined Intra- and Extra-articular ACL Reconstruction Versus Isolated Intra-articular ACL Reconstruction NCT06505525 | Federal University of São Paulo | N/A |
| Unknown | Absorbable Interface Screw Clinical Trial NCT05431790 | Peking University Third Hospital | N/A |
| Completed | Adductor Canal Block and IPACK Block vs. Isolated Adductor Canal Block for Post-Operative Analgesia Following NCT05286307 | NYU Langone Health | Phase 4 |
| Unknown | "Online Surveys" in Perioperative Knee Anterior Cruciate Ligament (ACL) Reconstruction NCT05423314 | University Hospital, Toulouse | — |
| Unknown | Femoral Triangle + IPACK Blocks for ACL Reconstruction Analgesia NCT05068063 | University of Chile | N/A |
| Unknown | Physical Activity, Knee Joint Loading and Joint Health NCT05306054 | University of Bath | — |
| Completed | Effects of Corporal Visualisation Program of the Static and Dynamic Balance After an Operation of the LCA NCT05081661 | HES-SO Valais-Wallis | N/A |
| Recruiting | Vibration on Patellofemoral Joint Pain After ACLR NCT05501210 | Chinese University of Hong Kong | N/A |
| Unknown | Knee vs. Ankle Training on Knee Mechanics After ACLR NCT05241795 | October 6 University | N/A |
| Unknown | Comparative Evaluation of Functional Results and Survival Rate of Peroneus Longus Tendon - PLT and Hamstring T NCT05579067 | eMKa MED Medical Center | N/A |
| Completed | The Effectıveness Of Structured Myofascial Chain Exercise Training After Anterior Cruciate Ligament Reconstruc NCT05423184 | Bahçeşehir University | N/A |
| Completed | External Focus of Attention Posttraumatic Osteoarthritis NCT04922268 | University of North Carolina, Charlotte | N/A |
| Unknown | Motor Imagery After Reconstruction of the Anterior Cruciate Ligament NCT05168033 | University Ghent | N/A |
| Completed | The Effects of Remnant-Preserving Anterior Cruciate Ligament Reconstruction on Proprioception and Functionalit NCT05057442 | Acibadem University | — |
| Completed | Reliability and Validity of Inline Dynamometry Study for Measuring Knee Extensor Torque NCT05109871 | Liverpool University Hospitals NHS Foundation Trust | N/A |
| Unknown | Diagnostic Study of ACL Rupture With Anterior Drawer Test at 90° of Hip Flexion NCT04957706 | Peking University Third Hospital | — |
| Unknown | A Clinical Trial of the Round-tunnel and Flat-tunnel Technique of ACL Reconstruction NCT04953676 | Peking University Third Hospital | N/A |
| Unknown | Reconstruction of the Anterior Cruciate Ligament of the Knee Joint, by the Method of Stabilization of the Scre NCT05328544 | eMKa MED Medical Center | N/A |
| Completed | The Effect of Subtalar Joint Antipronation Taping on the Dynamic Knee Valgus in Female Volleyball Players with NCT06752109 | Ankara Yildirim Beyazıt University | N/A |
| Completed | Werewolf Flow 50 During ACL Reconstruction NCT04998656 | University of Colorado, Denver | N/A |
| Unknown | Oral Administration of Tranexamic Acid in Anterior Cruciate Ligament Surgery Reduce Postoperative Haemarthrosi NCT04855877 | University of Liege | Phase 4 |
| Unknown | A Cohort Study of Non-surgical Treatment and Exercise Rehabilitation in Patients With Anterior Cruciate Ligame NCT05403905 | Peking University Third Hospital | N/A |
| Completed | The Effects of Hormonal Contraceptives on Incidence of ACL Injury Within Menstrual Cycle Phases NCT04986267 | University of South Australia | — |
| Recruiting | Follow-up of Anterior Cruciate Ligament Reconstruction NCT04781920 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Completed | Quantifying the Benefits of Supervised vs. Unsupervised Pre-habilitation for Patients With Acute ACL Tears NCT04593264 | WellSpan Health | N/A |
| Completed | Comparison of Different Anterior Cruciate Ligament Surgery Techniques in Skeletally Immature Patients. NCT04644497 | Aarhus University Hospital | — |
| Completed | Return to Work and Functional Results of French Soldiers After Anterior Cruciate Ligament Reconstruction NCT04668677 | Direction Centrale du Service de Santé des Armées | — |
| Recruiting | BFRT in Adolescents After ACL Reconstruction NCT04390035 | Children's Healthcare of Atlanta | N/A |
| Completed | Are Opioids Needed After ACL Reconstruction NCT04285853 | Emory University | Phase 4 |
| Unknown | Anterior Cruciate Ligament Reconstruction With Quadriceps Tendon Bone Autograft NCT05673356 | Artromedical Konrad Malinowski Clinic | N/A |
| Active Not Recruiting | Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial NCT04039971 | University of Colorado, Denver | N/A |
| Unknown | ALL Ultrasound Predicts the Success of ACL Repair? NCT04373408 | Adrien Schwitzguebel | — |
| Unknown | Analysis of Radiological Features of Lateral Femoral Impaction Fracture / Lateral Femoral Notch Sign NCT05682820 | Artromedical Konrad Malinowski Clinic | — |
| Recruiting | SEQUAR SEmitendinosus vs QUadriceps in Anterior Cruciate Ligament Reconstruction NCT04295148 | Karolinska Institutet | N/A |
| Terminated | Treatment of Acute ACL Injuries in Young Patients Using a Rebound ACL Brace NCT04185532 | Frida Hansson, MD | N/A |
| Completed | Improvement of Knowledge About the Arthrogenic Muscle Inhibition in the Aftermath of Knee Trauma. NCT03950024 | University Hospital, Toulouse | N/A |
| Completed | Central Sensitization Symptoms and Psychosocial Factors in Athletes After ACL Reconstruction NCT04393129 | University of Thessaly | — |
| Completed | Effects of Platelet Rich Plasma Injections on Biomarkers After Anterior Cruciate Ligament Tears NCT04088227 | Andrews Research & Education Foundation | Phase 2 |
| Unknown | Evaluation of the Effects of Home-based Functional Exercise on Patients With ACL NCT03890848 | Peking University Third Hospital | N/A |
| Unknown | Anatomic and Biomechanical Investigation on ACL: A Cadaveric Study NCT04957797 | Peking University Third Hospital | N/A |
| Unknown | Effect of LIA on Postoperative Pain Following ACL Reconstruction NCT03873077 | Algemeen Ziekenhuis Maria Middelares | N/A |
| Completed | Functional and Self-reported Outcomes in Participants With a History of Musculoskeletal Knee Injury NCT03617991 | Johanna M. Hoch | N/A |
| Completed | Acupuncture ACL (Anterior Cruciate Ligament) NCT03711734 | Hospital for Special Surgery, New York | N/A |
| Completed | Blood Flow Restriction Following ACL Reconstruction NCT03758755 | Inova Health Care Services | N/A |
| Completed | Combined Saphenous Nerve and IPACK Blocks Versus Infiltration Analgesia After Anterior Cruciate Ligament Recon NCT03680716 | Centre Hospitalier Universitaire Vaudois | N/A |
| Unknown | Association of ALL and ACL Reconstruction Versus Isolated ACL Reconstruction in High-risk Population: a RCT. NCT03229369 | Federal University of São Paulo | N/A |
| Terminated | Evaluation After Reconstruction of the Anterior Cruciate Ligament of the Knee Using the Bioresorbable Interfer NCT03529552 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Active Not Recruiting | Number One Overall Graft Pick? Hamstring vs Bone-Patellar-Tendon-Bone vs Quadriceps Tendon NCT03671421 | Panam Clinic | N/A |
| Unknown | Does Gabapentin Reduce Quadriceps Muscle Weakness After Anterior Cruciate Ligament Reconstruction? NCT03496389 | Hospital Authority, Hong Kong | Phase 2 / Phase 3 |
| Active Not Recruiting | The BEAR III Trial for Bridge-Enhanced ACL (Anterior Cruciate Ligament) Restoration NCT03348995 | Miach Orthopaedics | N/A |
| Active Not Recruiting | LIBRE (Ligamys, Internal Bracing, REconstruction) Study: Comparing Three Surgery Techniques After an Acute ACL NCT03441295 | University Hospital, Antwerp | N/A |
| Completed | Prospective Clinical Results of 3 Different Femoral Fixation in ACL Reconstruction NCT04677218 | Emre Kocazeybek | N/A |
| Unknown | Single and Double Bundle ACL Reconstructions, in Term of Cartilage Damage Due to Remaining Instability After S NCT04626999 | Indonesia University | N/A |
| Completed | BioCleanse Tibialis Tendon Anterior Cruciate Ligament (ACL) Study NCT00975845 | RTI Surgical | — |
| Enrolling By Invitation | Biologic Augmentation With Mesenchymal Stem Cells in Patients Undergoing Anterior Cruciate Ligament Reconstruc NCT04650568 | Rush University Medical Center | N/A |
| Enrolling By Invitation | Pain Management of ACL Reconstruction NCT03365908 | University of California, Davis | N/A |
| Completed | Risk Factor of Anterior Cruciate Ligament Rupture After Ligamentoplasty : What is the Importance of a Relative NCT03668210 | Rennes University Hospital | — |
| Unknown | Intra-articular Administration of 3.0g Tranexamic Acid Has no Effect on Reducing Intra-articular Hemarthrosis NCT04042688 | Korea University Guro Hospital | Phase 4 |
| Completed | Hamstring Muscle Strength After ACL Hamstring Reconstruction NCT05464485 | Isala | — |
| Unknown | Anterior Cruciate Ligament Rupture NCT02740452 | University Hospital, Clermont-Ferrand | N/A |
| Completed | Arthroscopic ACL Reconstruction: Hamstring Versus Quadriceps NCT04137250 | Universidad Autonoma de Nuevo Leon | N/A |
| Unknown | Anterior Cruciate Ligament Radiology Follow-up Study NCT02816606 | Royal Devon and Exeter NHS Foundation Trust | — |
| Completed | Improving Maximal Strength in the Initial Postoperative Phase After Anterior Cruciate Ligament Reconstruction NCT04224376 | Hannover Medical School | N/A |
| Unknown | Comparison of Remnant Preserving Versus Remnant Resecting Anterior Cruciate Ligament Reconstruction NCT02555917 | The Catholic University of Korea | N/A |
| Unknown | Comparative Study of Anterior Tibial Translation Measurement by Four Laximeters in Anterior Cruciate Ligament NCT02875210 | Versailles Hospital | N/A |
| Completed | Tolerance, Efficacy, revAlidation, Myostim NCT04684771 | Alternativa International S.A | N/A |
| Unknown | Efficacy of Preoperative Re-education on Patients With an Anterior Cruciate Ligament Rupture NCT02505659 | University Hospital, Clermont-Ferrand | N/A |
| Completed | Comparison of Functional Outcome Between BQT and SBHT ACL Reconstruction NCT04536246 | Indonesia University | N/A |
| Completed | Liposomal Bupivacaine for Pain Control Following Anterior Cruciate Ligament Reconstruction NCT02189317 | Emory University | Phase 4 |
| Completed | Induced ACL Healing With the Ligamys Technique: a Prospective, Multicenter Observational Case Series NCT02203214 | Mathys Ltd Bettlach | — |
| Unknown | Safety and Efficacy of the Knee-T-nol Anterior Cruciate Ligament (ACL) Prosthesis NCT01450332 | Tavor Ltd. | N/A |
| Completed | Evaluation of Tibial and Femoral Tunnel Position After Arthroscopic Reconstruction of the Anterior Cruciate Li NCT01267435 | Isfahan University of Medical Sciences | Phase 2 |
| Completed | Single Bundle Anterior Cruciate Ligament Reconstruction in Active Young Men NCT01533025 | National Police Hospital | N/A |
| Completed | Femoral Tunnel Position on Conventional MRI After Anterior Cruciate Ligament Reconstruction-Transtibial Techni NCT01513434 | National Police Hospital | N/A |
| Completed | Comparison of Three Methods for Anterior Cruciate Ligament Reconstruction NCT00529958 | University of Calgary | N/A |
| Completed | Allogeneic Bone-patellar Tendon-bone Transplantation NCT04951531 | Peking University Third Hospital | N/A |
| Completed | Initial Graft Tension and ACL Surgery NCT00434837 | Rhode Island Hospital | N/A |
| Completed | Effect of Tunnel Placements on Clinical and MRI Findings Two Years After ACL Reconstruction With DB Technique NCT02000258 | Tampere University Hospital | N/A |
| Unknown | The Clinical Outcome of Anterior Cruciate Ligament Reconstruction NCT03984474 | Peking University Third Hospital | — |
| Completed | RCT of PEP Program to Reduce ACL Injuries in Female Collegiate Soccer Players NCT00140270 | Centers for Disease Control and Prevention | Phase 2 |
| Completed | Pain Relief Results After Anterior Cruciate Ligament (ACL) Reconstruction NCT00022854 | University of Pittsburgh | Phase 4 |