| Not Yet Recruiting | Short Course or Long Course Radiotherapy as Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer NCT07258797 | Rajiv Gandhi Cancer Institute & Research Center, India | N/A |
| Recruiting | A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer NCT06637462 | Memorial Sloan Kettering Cancer Center | N/A |
| Recruiting | A Study of Tucatinib and Trastuzumab in People With Rectal Cancer NCT05672524 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Recruiting | The Utility and Feasibility of Mt-sDNA as a Surveillance Procedure in Colorectal Cancer Survivors NCT04624555 | Case Comprehensive Cancer Center | — |
| Recruiting | Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps NCT05080673 | NRG Oncology | N/A |
| Completed | MoLiMoR - A Study With FOLFIRI-based First-line Therapy With or Without Intermittent Cetuximab NCT04554836 | TheraOp | Phase 2 |
| Recruiting | Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation NCT04668872 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Pembrolizumab In Combination With Debio 1143 In Pancreatic and Colorectal Advanced/Metastatic Adenocarcinoma NCT03871959 | Centre Leon Berard | Phase 1 |
| Unknown | Human Intestinal Microbiome and Surgical Outcomes in Patients Undergoing Colorectal Cancer Surgery NCT04005118 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits NCT03303547 | Imperial College London | N/A |
| Active Not Recruiting | Can We Save the Rectum by Watchful Waiting or TransAnal Surgery Following (chemo)Radiotherapy Versus Total Mes NCT02945566 | University of Birmingham | Phase 2 / Phase 3 |
| Completed | Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum NCT02641691 | Washington University School of Medicine | Phase 2 |
| Terminated | Study of Colorectal Cancer Patients (Stage IIIC) With Either Regorafenib or Standard of Care (No Treatment) Af NCT02425683 | US Oncology Research | Phase 2 |
| Withdrawn | Phase II Study of Zaltrap and Chemotherapy for Advanced Resectable Colorectal Cancer NCT02046538 | Weill Medical College of Cornell University | Phase 2 |
| Completed | Midostaurin (PKC412) for Locally Advanced Rectal Cancer NCT01282502 | Massachusetts General Hospital | Phase 1 |
| Completed | Laparoscopy-Assisted Transanal Endoscopy Rectosigmoid Resection for Rectal Cancer NCT01340755 | Massachusetts General Hospital | N/A |
| Completed | Study of AUY922 and Cetuximab in Patients With KRAS Wild-Type Metastatic Colorectal Cancer NCT01294826 | Swedish Medical Center | Phase 1 |
| Withdrawn | Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients With Metastatic Colore NCT01270438 | National Cancer Institute (NCI) | Phase 2 |
| Unknown | Optimum Timing for Surgery After Pre-operative Radiotherapy 6 vs 12 Weeks NCT01037049 | Royal Marsden NHS Foundation Trust | Phase 2 |
| Completed | Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer NCT01037790 | Abramson Cancer Center at Penn Medicine | Phase 2 |
| Completed | Vorinostat, Fluorouracil, and Leucovorin Calcium in Treating Patients With Metastatic Colorectal Cancer That H NCT00942266 | Roswell Park Cancer Institute | Phase 2 |
| Completed | Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat NCT00707889 | AbbVie (prior sponsor, Abbott) | Phase 2 |
| Completed | Pertuzumab and Cetuximab in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorecta NCT00551421 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Completed | Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Nec NCT00397384 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery NCT00433576 | National Cancer Institute (NCI) | Phase 1 |
| Terminated | AZD0530 (NSC 735464) in Treating Patients With Previously Treated Metastatic Colon Cancer or Rectal Cancer NCT00397878 | National Cancer Institute (NCI) | Phase 2 |
| Terminated | Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III Rectal Cancer NCT00303628 | ECOG-ACRIN Cancer Research Group | Phase 3 |
| Completed | Bevacizumab, Erlotinib and 5-Fluorouracil With External Beam Radiation Therapy in Locally Advanced Rectal Canc NCT00307736 | Massachusetts General Hospital | Phase 1 / Phase 2 |
| Completed | Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer NCT00100841 | National Cancer Institute (NCI) | Phase 2 |
| Terminated | Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced, Metastatic, or Recurrent NCT00070122 | National Cancer Institute (NCI) | Phase 3 |
| Terminated | Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent Colorectal Cancer NCT00052585 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Bevacizumab, Fluorouracil, and External-Beam Radiation Therapy in Treating Patients With Stage II or Stage III NCT00052559 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Hepatic Arterial Infusion Plus Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Live NCT00026234 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Erlotinib in Treating Patients With Recurrent or Metastatic Colorectal Cancer NCT00032110 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Vaccine Therapy With or Without Sargramostim in Treating Patients With Advanced or Metastatic Cancer NCT00028496 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Recurrent or Persistent Metastatic Colorect NCT00023933 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With NCT00025337 | National Cancer Institute (NCI) | Phase 3 |
| Completed | Oxaliplatin, Fluorouracil, and External-Beam Radiation Therapy Followed by Surgery in Treating Patients With L NCT00006094 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Completed | SU5416 and Irinotecan in Treating Patients With Advanced Colorectal Cancer NCT00005818 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Completed | Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Rectal Cancer NCT00003799 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal Cancer NCT00003873 | National Cancer Institute (NCI) | Phase 3 |