| Active Not Recruiting | Effects of Saccharomyces Boulardii CNCM I-745 on Antibiotic-Associated Perturbation in Children Treated for Ac NCT07015736 | Eskisehir Osmangazi University | Phase 4 |
| Not Yet Recruiting | Comparison of Amoxicillin and Amoxicillin + Clavulanic Acid in Treating Acute Otitis Media in Children NCT06895135 | University of Health Sciences Lahore | N/A |
| Recruiting | Interventions to De-implement Unnecessary Antibiotic Prescribing for Children With Ear Infections NCT06034080 | Intermountain Health Care, Inc. | N/A |
| Active Not Recruiting | RELAX: Reducing Length of Antibiotics for Children With Ear Infections NCT05608993 | Intermountain Health Care, Inc. | N/A |
| Recruiting | Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Re NCT05915078 | Smith & Nephew, Inc. | — |
| Completed | Supporting Parents to Choose Wisely NCT06005337 | University of Alberta | N/A |
| Completed | Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventio NCT06027593 | Children's Hospital of Philadelphia | N/A |
| Terminated | Analgesic Ear Drops for Children With Acute Otitis Media NCT05651633 | UMC Utrecht | Phase 3 |
| Active Not Recruiting | Dynamic Change and Immune Response to Nasopharyngeal Carriage and Acute Otitis Media Pathogens NCT04946084 | Rochester General Hospital | N/A |
| Completed | Evaluation of Cellphone Based Otoscopy in Pediatric Patients NCT04296448 | Johns Hopkins University | N/A |
| Completed | An Epidemiological Survey to Establish the Spectrum of Circulating Serotypes of S. Pneumoniae, in Patients Old NCT04464291 | The Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC) | N/A |
| Completed | A Study to Assess the Safety, Tolerability and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Med NCT03818815 | Novus Therapeutics, Inc | Phase 2 |
| Completed | Evaluation of Safety and Reduction of Ear Pain in Adults With Acute Otitis Media and Reduction of Ear Pain in NCT03766373 | Novus Therapeutics, Inc | Phase 1 |
| Completed | Effect of a New Probiotic Strain on Recurrent Acute Otitis Media in Children (PROMAR) NCT03614117 | ProbiSearch SL | N/A |
| Withdrawn | Efficacy of the EarPopper Device in Children With Recurrent Otitis Media NCT03534219 | Northwell Health | N/A |
| Unknown | Bio-Kult Infantis® in AAD Prevention in Infants NCT03516409 | Probiotics International Ltd. | N/A |
| Unknown | Taste Changes in Acute Otitis Media NCT03315156 | Tel-Aviv Sourasky Medical Center | — |
| Unknown | Xylitol for the Prevention of Acute Otitis Media Episodes in Children NCT03055091 | Unity Health Toronto | N/A |
| Completed | Shared Decision Making in Parents of Children With Acute Otitis Media NCT02872558 | Mayo Clinic | N/A |
| Unknown | The Effect of Early Non-Surgical Treatment of Children With Middle Ear Effusion on the Hearing NCT02549612 | Vastra Gotaland Region | N/A |
| Completed | Phase III Study Evaluating Topical Benzocaine for Treatment of Acute Otitis Media in Children NCT03116737 | Lachlan Pharma Holdings | Phase 3 |
| Completed | Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children NCT02935374 | University of Oulu | Phase 4 |
| Completed | Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto) NCT02918773 | Emory University | N/A |
| Completed | Preliminary Testing of the Vitaliti CVSM Wearable, Vitaliti Spirotoscope, and Vitaliti IVD Station NCT02856633 | Cloud DX Inc. | — |
| Completed | Impact of Pneumococcal Conjugate Vaccines on Otitis Media and Acute Otitis Media in Swedish Children NCT02742753 | GlaxoSmithKline | — |
| Completed | Dose Ranging Study of OTO-201 in AOMT NCT02719158 | Otonomy, Inc. | Phase 2 |
| Completed | Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media NCT02630992 | Nader Shaikh | Phase 3 |
| Completed | Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media NCT02567825 | Alejandro Hoberman | N/A |
| Completed | Vaccination Impact Against Pneumococcal Disease on Acute Otitis Media Morbidity in Colombian Children < 5 Year NCT02567747 | GlaxoSmithKline | — |
| Completed | Mobile Otoscopy - Efficacy of Residents to Diagnose Acute Otitis Media Using a Smartphone Otoscope Attachment NCT02521597 | St. Justine's Hospital | N/A |
| Completed | Improving Antibiotic Prescribing for Pediatric Respiratory Infections by Family Physicians With Peer Compariso NCT04588376 | Herb Clegg | N/A |
| Completed | Open-Label Study of OTO-201 for Treatment of AOMT NCT02408796 | Otonomy, Inc. | Phase 2 |
| Completed | Comparative Effectiveness of Antibiotics for Respiratory Infections NCT02297815 | Children's Hospital of Philadelphia | — |
| Terminated | Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (A NCT02074007 | Arbor Pharmaceuticals, Inc. | Phase 3 |
| Completed | Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Oti NCT02044341 | Arbor Pharmaceuticals, Inc. | Phase 3 |
| Terminated | Proof-of-Concept Study of a Single Application of an Investigational Otic Suspension in Treatment of Acute Oti NCT01908803 | Alcon Research | Phase 2 |
| Completed | Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Media NCT02037893 | Currax Pharmaceuticals | Phase 2 |
| Completed | Does Tympanometry Predict Antibiotic Usage in Acute Otitis Media? NCT01941381 | University of Alberta | — |
| Completed | Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence NCT02345447 | University Hospital Tuebingen | Phase 3 |
| Completed | Study to Assess the Safety and Efficacy of Benzocaine for Pain Relief in Children Presenting With Acute Otitis NCT02092454 | Otic Therapy, LLC | Phase 2 |
| Completed | Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics) NCT01800747 | Asociacion Colaboracion Cochrane Iberoamericana | Phase 4 |
| Terminated | Efficacy of Short-Course Antimicrobial Treatment for Children With Acute Otitis Media and Impact on Resistance NCT01511107 | Alejandro Hoberman | Phase 2 |
| Completed | Clinical Study to Assess the Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle NCT01395966 | Salvat | Phase 3 |
| Completed | Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric P NCT01404611 | Salvat | Phase 3 |
| Completed | Lactobacillus Rhamnosus GG in the Middle Ear and Adenoid Tonsil NCT02110732 | Helsinki University Central Hospital | N/A |
| Unknown | Assessment of the Natural Antibody Response to Pneumococcal Surface Proteins During Acute Otitis Media in Chil NCT01214538 | NasVax Ltd | — |
| Completed | Evaluation of the Tympanostomy Tube Delivery System NCT01202578 | Integra LifeSciences Corporation | Phase 2 / Phase 3 |
| Terminated | Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in Taiwa NCT01072227 | GlaxoSmithKline | — |
| Completed | Impact of Prevnar 13 on Ear Infections in Children NCT01272999 | Pfizer | — |
| Completed | Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children NCT01044030 | Boston Children's Hospital | Phase 3 |
| Terminated | Safety and Efficacy of Moxidex Otic NCT01071902 | Alcon Research | Phase 3 |
| Completed | Topical Treatment of Acute Otitis Media Through Tympanostomy Tubes (AOMT) and Its Effect on Microbial Flora NCT01027494 | Alcon Research | — |
| Completed | Study to Identify and Characterize Bacteria Causing Acute Otitis Media in South African Children NCT01031082 | GlaxoSmithKline | — |
| Completed | Pharmacokinetics Of Azithromycin Immediate Release And Extended Release Formulation In Kids With Acute Otitis NCT00796224 | Pfizer | Phase 2 |
| Completed | Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus NCT00941993 | Integra LifeSciences Corporation | N/A |
| Completed | Ear Drops for Children With Otitis Media NCT00622518 | University of Washington | N/A |
| Completed | A Phase II Study of an Otic Formulation in Treating Peri-Operative Tube Otorrhea NCT00578773 | Alcon Research | Phase 2 |
| Withdrawn | Is There Hearing Loss After Acute Mastoiditis NCT00502450 | Rabin Medical Center | — |
| Completed | Acute Otitis Media (AOM) Therapy Trial in Young Children NCT00377260 | University of Pittsburgh | Phase 4 |
| Completed | PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers NCT00714064 | Menzies School of Health Research | Phase 3 |
| Unknown | PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear NCT00310349 | University of Melbourne | Phase 3 |
| Unknown | Amoxicillin Clavulanate in Treatment of Acute Otitis Media NCT00299455 | University of Turku | Phase 4 |
| Completed | Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes NCT00579189 | Alcon Research | Phase 3 |
| Completed | A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes NCT00578474 | Alcon Research | Phase 3 |
| Completed | A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children NCT00189462 | Deborah Gentile | Phase 4 |
| Completed | A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With NCT00645112 | Abbott | Phase 4 |
| Completed | A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatri NCT00644943 | Abbott | Phase 4 |
| Completed | A Single, High-Dose Azithromycin Extended Release (60 mg/kg) Compared With 10 Days of High-Dose Amoxicillin Cl NCT00643292 | Pfizer | Phase 3 |
| Completed | Safety and Efficacy Study of Cefdinir Oral Suspension, in Pediatric Subjects to Treat Acute Otitis Media NCT00645203 | Abbott | Phase 2 / Phase 3 |
| Completed | A Trial of Point of Care Information in Ambulatory Pediatrics NCT00368823 | University of Washington | Phase 3 |