NCT07491627

Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment

Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment, in Conventional and Non Smokers: a Controlled Clinical Trial

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 56 (estimated)
• Sponsor: University of Liege · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Impact of nicotine gingival intoxication on the clinical outcomes after periodontitis non surgical treatment

Detailed description

In patients suffured of periodontitis, to evaluate the effect of nicotine gingival tissue intoxication and others smoking indicators on the severity of periodontitis and outcomes after nonsurgical periodontal treatment."

Conditions

• Periodontitis
• Smoking Cessation
• Tobacco Dependence

Interventions

Type	Name	Description
PROCEDURE	periodontal non-surgical treatment	The procedure will consist of non-surgical periodontal treatment (NSPT), consisting of the removal of supra- and subgingival plaque using ultrasonic instruments. Prior to the NSPT, all unstimulated saliva will be collected using Eppendorf. During local anesthesia for the NSPT, a gingival tissue biopsy will be performed using a 2mm wide and 4mm deep punch in the maxillary retromolar area behind the last tooth in the arch.

Timeline

• Start date: 2025-01-06
• Primary completion: 2029-06-01
• Completion: 2029-06-01
• First posted: 2026-03-24
• Last updated: 2026-03-24

Locations

1 site across 1 country: Belgium