NCT07325175

Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (estimated)
• Sponsor: Children's Hospital Medical Center, Cincinnati · Academic / Other
• Sex: All
• Age: 6 Years – 21 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are: How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)? Participants will: * Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task. * Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.

Conditions

• Dystonia
• Pediatric
• Deep Brain Stimulation
• Motor Development

Interventions

Type	Name	Description
DEVICE	DBS	Subjects with DBS will complete protocol with and without active stimulation

Timeline

• Start date: 2024-01-01
• Primary completion: 2029-12-31
• Completion: 2029-12-31
• First posted: 2026-01-08
• Last updated: 2026-01-08

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study