NCT07253181

Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours

Tenecteplase Before inteRhospital Transfer for Endovascular Treatment in pAtientS With acUte Anterior ciRculation Large vEssel Occlusion at 4.5 to 24 Hours

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 572 (estimated)
• Sponsor: Xuanwu Hospital, Beijing · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will address the efficacy and safety of Tenecteplase administered in non-endovascular capable center (nECC) in patients with acute ischemic stroke (AIS) caused by anterior circulation large vessel occlusion (acLVO) who present in the 4.5- to 24-hour time window before interhospital transfer to an endovascular capable center (ECC) for endovascular treatment (EVT). * Primary objective: To evaluate the efficacy and safety of Tenecteplase administration at a nECC before EVT transfer compared with standard of care * Secondary objective: To evaluate the impact of time from needle-to-arterial puncture on clinical outcomes Patients who meet inclusion criteria will be randomized to Tenecteplase (0.25mg/kg, maximum 25mg) before transfer or standard of care. A single bolus dose should be injected over 5 seconds.

Conditions

• Acute Ischemic Stroke
• Large Vessel Occlusion
• Transportation of Patients

Interventions

Type	Name	Description
DRUG	Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)	Tenecteplase at a nECC before EVT transfer

Timeline

• Start date: 2026-01-06
• Primary completion: 2028-03-30
• Completion: 2028-03-30
• First posted: 2025-11-28
• Last updated: 2026-03-19

Locations

2 sites across 1 country: China