NCT07165054

Periodontal Pathogens and Atherom Plaque The Number of Mitochondrial DNA Copies

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 51 (actual)
• Sponsor: Istanbul Saglik Bilimleri University · Academic / Other
• Sex: All
• Age: 25 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.

Detailed description

Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream. Periodontal bacteria produce endotoxins in the form of lipopolysaccharide (LPS). Circulating LPS reacts with Toll-like receptors, promoting the production of reactive oxygen species and phagocytosis in the intima layer. Oxidative stress has been reported to be associated with mtDNA copy number.

Conditions

• Periodontal Inflammation
• Biofilm
• Endothelial Dysfunction
• Oral Bacteria

Interventions

Type	Name	Description
OTHER	atheroma plaque	Before the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.
OTHER	Dental plaque	Subgingival plaque samples will be collected from patients before the endarterectomy procedure.

Timeline

• Start date: 2025-04-10
• Primary completion: 2025-11-01
• Completion: 2025-12-01
• First posted: 2025-09-10
• Last updated: 2026-01-30

Locations

1 site across 1 country: Turkey (Türkiye)