NCT07050212

Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation

A Comparative Study of the Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Maternal and Child Health Hospital of Hubei Province · Academic / Other
• Sex: All
• Age: 2 Years – 5 Years
• Healthy volunteers: Accepted

Summary

By comparing the application effects of three drugs in pediatric preoperative sedation, this study explores the optimal medication regimen, aiming to provide safer, more effective, and more personalized medication options for pediatric preoperative sedation. Additionally, this research will also focus on the impact of these three drugs on postoperative agitation in children, offering valuable references for the overall management of pediatric surgical anesthesia.

Detailed description

Participants will be randomly allocated to three groups: remimazolam group(Group A), dexmedetomidine group(Group B), esketamine group(Group C). Before entering the operating room, an intravenous access is established. Under the accompaniment of a parent, one of the three drugs is administered intravenously.

Conditions

• Remimazolam
• Dexmedetomidine
• Esketamine

Interventions

Type	Name	Description
DRUG	remimazolam group	remimazolam is administered intravenously at a dose of 0.3 mg/kg
DRUG	dexmedetomidine group	dexmedetomidine is administered intravenously at a dose of 1 μg/kg
DRUG	esketamine group	esketamine is administered intravenously at a dose of 0.5 mg/kg

Timeline

• Start date: 2025-04-01
• Primary completion: 2026-03-01
• Completion: 2026-03-01
• First posted: 2025-07-03
• Last updated: 2025-07-10

Locations

1 site across 1 country: China