| Recruiting | Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients NCT07479602 | Peking University First Hospital | Phase 4 |
| Not Yet Recruiting | Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery NCT07523321 | Peking University First Hospital | Phase 4 |
| Not Yet Recruiting | Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients NCT07523334 | Peking University First Hospital | Phase 4 |
| Not Yet Recruiting | Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery NCT07525999 | Peking University First Hospital | Phase 4 |
| Recruiting | Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery NCT07308756 | Peking University First Hospital | Phase 4 |
| Recruiting | Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study NCT07247968 | Min Su | EARLY_Phase 1 |
| Not Yet Recruiting | Dexmedetomidine-Esketamine Combination for Sedation and Analgesia in ICU Patients NCT06468436 | Peking University First Hospital | N/A |
| Recruiting | Sedation With Dexmedetomidine-esketamine Combination and Delirium in ICU Patients NCT07151716 | Peking University First Hospital | Phase 4 |
| Recruiting | The Efficacy and Safety of Short Term S-ketamine Infusion as an Adjunctive Therapy in Patients With Fibromyalg NCT07230171 | Beijing Tiantan Hospital | N/A |
| Completed | Dexmedetomidine-esketamine-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia NCT07145775 | Peking University First Hospital | Phase 4 |
| Not Yet Recruiting | Etomidate and Esketamine on Postoperative Pain After Tonsillectomy Undergoing Children NCT07062601 | Anqing Municipal Hospital | N/A |
| Recruiting | Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation NCT07050212 | Maternal and Child Health Hospital of Hubei Province | N/A |
| Recruiting | Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery NCT06859892 | Peking University First Hospital | Phase 4 |
| Recruiting | Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine f NCT06853431 | Second Affiliated Hospital of Wenzhou Medical University | Phase 4 |
| Not Yet Recruiting | Effects of Esketamine on Oxygenation and Quality of Recovery in Patients Undergoing Thoracoscopic Surgery NCT06822088 | Jinqiao Qian | Phase 4 |
| Recruiting | Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT) NCT06817239 | Nanfang Hospital, Southern Medical University | N/A |
| Recruiting | Effect of Subanesthetic Dose of Esketamine on Sleep Quality NCT06773143 | Nanjing First Hospital, Nanjing Medical University | N/A |
| Completed | Different Doses of Dexmedetomidine Combined With Esketamine in Women Undergoing Cesarean Delivery NCT06613243 | Peking University First Hospital | Phase 4 |
| Recruiting | Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA NCT06566482 | Peking University First Hospital | Phase 4 |
| Completed | Dexmedetomidine-esketamine Combined Nasal Administration and Emergence Delirium NCT06566469 | Peking University First Hospital | Phase 4 |
| Recruiting | Esketamine in Microelectrode Recording-guided Subthalamic Deep-Brain Stimulation for Parkinson's Disease NCT06543563 | Beijing Tiantan Hospital | N/A |
| Completed | Effect of Esketamine on Anxiety State in Patients Undergoing Abdominal Tumor Surgery NCT06530706 | Zhejiang Cancer Hospital | N/A |
| Recruiting | Esketamine on Postoperative Sleep Disturbance of Patients Undergoing Spinal Surgery NCT06451627 | Beijing Tiantan Hospital | N/A |
| Recruiting | Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort NCT06399185 | Peking University First Hospital | Phase 4 |
| Recruiting | Effect of Esketamine on Conscious State in Patients With pDoC NCT06389344 | Beijing Tiantan Hospital | N/A |
| Recruiting | Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes NCT06087510 | Peking University First Hospital | Phase 4 |
| Recruiting | Fentanyl or Esketamine for Traumatic PAIN (FORE-PAIN) Trial NCT06051227 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 3 |
| Unknown | Esketamine Combined With Pregabalin on CPSP in Spinal Patients. NCT06117917 | Beijing Tiantan Hospital | Phase 2 / Phase 3 |
| Recruiting | Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality NCT05950646 | Peking University First Hospital | Phase 4 |
| Completed | Night-time Dexmedetomidine-esketamine Infusion and Sleep Quality in ICU Patients NCT05718024 | Peking University First Hospital | Phase 4 |
| Active Not Recruiting | Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correctio NCT06062550 | Peking University First Hospital | Phase 4 |
| Completed | Dexmedetomidine-esketamine for Percutaneous Radiofrequency Liver Ablation NCT06003218 | Peking University First Hospital | N/A |
| Unknown | Effect of Subanesthetic Dose Esketamine on Propofol-refentanil Closed-loop Targeted Controlled Infusion NCT05943028 | bo xu | EARLY_Phase 1 |
| Completed | Dexmedetomidine-esketamine Combined Nasal Administration and Perioperative Sleep Quality NCT05732064 | Peking University First Hospital | Phase 4 |
| Unknown | Median Effective Dose of Esketamine Pretreatment to Prevent Sufentanil-induced Cough NCT05809804 | Yangzhou University | N/A |
| Completed | Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes NCT05718544 | Peking University First Hospital | Phase 4 |
| Completed | Esketamine Combined With Dexmedetomidine Sedation in Head MRI Examination of Children With Autism Spectrum Dis NCT06633315 | Maternal and Child Health Hospital of Hubei Province | Phase 2 |
| Completed | An Exploratory Study of Esketamine in Patients After Thoracoscopic Surgery NCT05458453 | The Second Affiliated Hospital of Chongqing Medical University | Phase 4 |
| Unknown | Safety and Efficacy Evaluation of S (+) - Ketamine in Children NCT04834427 | Chinese PLA General Hospital | Phase 4 |
| Completed | Esketamine and Butorphanol for Post-Lobectomy Pain NCT06398834 | Second People's Hospital of Hefei City | Phase 4 |
| Completed | Anesthesia for Loop Electrosurgical Excision Procedure (LEEP). NCT06574945 | Qian Wu | Phase 4 |
| Completed | Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neo NCT05096468 | Beijing Tiantan Hospital | Phase 2 / Phase 3 |
| Unknown | The Effectiveness and Safety of Esketamine in Modified Electroconvulsive Therapy NCT04777110 | First Affiliated Hospital of Chongqing Medical University | EARLY_Phase 1 |
| Recruiting | Immunoinflammatory Regulation of Esketamine in Septic Patients NCT04843982 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 4 |
| Completed | Esketamine on Postpartum Depression in Cesarean Section Women NCT04860661 | Ailin Luo | N/A |
| Completed | Esketamine and Perioperative Depressive Symptoms NCT04425473 | Beijing Tiantan Hospital | Phase 2 / Phase 3 |
| Unknown | The Study on the Esketamine in the Treatment of Postherpetic Neuralgia NCT04664530 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 4 |
| Completed | The Effects of Intraoperative Esketamine on Postoperative Pain and Mood in Patients With Inflammatory Bowel Di NCT05506787 | Jinling Hospital, China | Phase 4 |