NCT06626607

Different Antihypertensive Drugs on Aortic Diseases

A Study of the Effect of Different Antihypertensive Drugs on the Disease Progression of Aortic Dissection/Aneurysm

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 704 (actual)
• Sponsor: Eighth Affiliated Hospital, Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to learn about the effect of different hypotensive drugs on the prognosis of postoperative aortic patients. The main question it aims to answer is: Does different hypotensive drugs influence the prognosis of postoperative aortic patients? As participants already taking hypotensive drugs as part of their regular medical care, the investigators collect the participants' pre-operation medical record and post-operative follow-up record to evaluate the aorta condition.

Detailed description

This study is a cohort study that aims to explore the effects of different antihypertensive regimens on aortic remodelling in patients after aortic surgery by collecting the hospitalization and outpatient follow-up data. The study plans to gather perioperative and postoperative follow-up data from over 600 patients who underwent aortic surgery at the Eighth Affiliated Hospital and Beijing Anzhen Cardiothoracic Surgery Center. Patients were assigned based on the postoperative antihypertensive medication regimens. Datas was collected to compare the cardiovascular-related prognoses. This study primarily includes patients who take oral antihypertensive medications after aortic surgery. The main observations will focus on postoperative complications related to the aorta (such as death, reoperation, dilation, etc.) and aortic diameters after the administration of different antihypertensive medications. Multivariate regression analysis will be employed to investigate the impact of different antihypertensive regimens on patients after aortic surgery.

Conditions

• Aortic Aneurysm
• Aortic Dissection

Interventions

Type	Name	Description
DRUG	CCB use	Postoperative antihypertensive medication includes CCB
DRUG	non-CCB use	Postoperative antihypertensive medication does not include CCB

Timeline

• Start date: 2017-01-01
• Primary completion: 2024-05-30
• Completion: 2024-09-30
• First posted: 2024-10-04
• Last updated: 2024-10-04