NCT06381180

Warrior CARE: Cannabis Behavioral Health

Wayne Warrior CAnnabis Research and Education: Cannabis and Behavioral Health

• Status: Not Yet Recruiting
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 500 (estimated)
• Sponsor: Wayne State University · Academic / Other
• Sex: All
• Age: 19 Years – 69 Years
• Healthy volunteers: Not accepted

Summary

This study is a randomized, controlled clinical trial to examine the therapeutic potential of cannabinoids for treating veterans with PTSD and suicidal ideation.

Detailed description

In this clinical trial, we will recruit veterans with PTSD who report using cannabis or have interest in trying cannabis for symptom relief. Veterans will be randomized into one of four different groups: THC (∆9-tetrahydrocannabinol), CBD (cannabidiol), THC+CBD, and Placebo, and undergo a 12-week treatment phase where they will be asked to smoke their assigned cannabis dose every day for 12 weeks. Participants will complete weekly questionnaires regarding their mood, behavior and drug consumption. Furthermore, there is a laboratory component that will assess cognition, fear conditioning, and other PTSD-related measures.

Conditions

• Post Traumatic Stress Disorder
• Cannabis Use
• Suicide
• Veterans
• Marijuana

Interventions

Type	Name	Description
DRUG	Tetrahydrocannabinol	Plant cannabis that will be smoked
DRUG	Cannabidiol	Plant cannabidiol that will be smoked
DRUG	Placebo	Plant will be smoked.

Timeline

• Start date: 2025-09-22
• Primary completion: 2030-12-31
• Completion: 2030-12-31
• First posted: 2024-04-24
• Last updated: 2025-09-29

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study