NCT06368271

Acute Effects of Dietary Medium-chain Fatty Acids on Lipid Profile

Acute Effects of Dietary Medium-chain Fatty Acids on Llipid Profile

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (actual)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: Male
• Age: 20 Years – 30 Years
• Healthy volunteers: Accepted

Summary

In the present study the plasma lipid profile was elucidated in healthy, lean males by the use of lipidomic analysis in the hours after an acute intake of medium-chain fatty acids (MCT) and long chain fatty acids (LCT),, respectively. In addition oxygen uptake was measured to study energy turnover.

Detailed description

Four participants ingested MCT or LCT oil on two test days with one-week period between the experimental days. The day prior to the experimental days, the participants consumed a eucaloric control diet, and abstained from alcohol and vigorous physical activity to ensure similar conditions on experimental days. On the test days, participants arrived by passive transport in the overnight fasted state (12 h) at 8 a.m., and a catheter was inserted into an antecubital vein. Following 30 min in supine rest, an overnight-fasted, basal venous blood sample was obtained. Subsequently, participants ingested the same test drink as in study 1 (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carbohydrate cocoa milk) within five min. 100 ml water was provided together with the test drink. Venous blood samples were drawn every 30 min for the first two hours and every 60 minutes for the last two hours following intake. Participants rested in a bed throughout the test day. this This process was repeated on the second test day.

Conditions

• Healthy Nutrition
• Diet, Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Lipidomics	Health beneficial effects of medium-chain fatty acids

Timeline

• Start date: 2021-10-01
• Primary completion: 2024-02-28
• Completion: 2024-02-28
• First posted: 2024-04-16
• Last updated: 2024-04-16

Locations

2 sites across 1 country: Denmark