NCT06096454

Effect of Life Style Modification and Metformin on Hypothyroidism With Insulin Resistance

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is the effect of lifestyle modification and metformin on hypothyroidism with insulin resistance

Detailed description

Hypothyroidism happens when the thyroid does not create and release enough thyroid hormone in the body this make the metabolism slow down . Thyroid hormones T3 and T4 maintain a fine balance of glucose homeostasis by acting as insulin agonistic and antagonistic. Hypothyroidism can break this equilibrium and alter glucose metabolism, which can lead to insulin resistance. Insulin resistance is defined clinically as the inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilization in an individual as much as it does in a normal population. In this work we assess the lifestyle modification (i.e. diet and exercise)and metformin on insulin resistance

Conditions

• Hypothyroidism
• Insulin Resistance

Interventions

Type	Name	Description
DRUG	Metformin	effect of life style modification and metformin on hypothyroidism with insulin resistance

Timeline

• Start date: 2023-11-20
• Primary completion: 2024-09-20
• Completion: 2024-10-30
• First posted: 2023-10-23
• Last updated: 2023-10-23