NCT06051292

Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement

Decremental Esophageal Catheter Filling Volume Titration For Esophageal Pressure Measurement

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (estimated)
• Sponsor: Dr. Behcet Uz Children's Hospital · Academic / Other
• Sex: All
• Age: 1 Month – 18 Years
• Healthy volunteers: Not accepted

Summary

Mechanical ventilation is a critical intervention in the management of pediatric patients with respiratory distress. During this process, accurate measurement of transpulmonary pressure (PL) is essential to ensure the safety and efficacy of ventilation. PL is defined as the difference between alveolar pressure (Palv) and pleural pressure (Ppl). While the direct measurement of Ppl is possible, it poses a risk to tissue integrity. Thus, the primary surrogate for Ppl measurement today is esophageal pressure (Pes). However, the measurement of Pes is not without challenges. This abstract outlines the pitfalls associated with Pes measurement, emphasizing the importance of employing well-defined procedures to mitigate potential errors. These errors can range from underestimation of Pes due to underfilled catheters to overestimation resulting from overfilled catheters. To address these challenges and optimize Pes measurement, various methods have been proposed for titrating the filling volume of the esophageal catheter. In this study, investigators aim to assess a faster decremental filling method and compare it to the traditionally accepted Mojoli method in the context of pediatric patients. This research seeks to enhance the intensivists' understanding of the most efficient and accurate approach to Pes measurement during mechanical ventilation in the pediatric population, ultimately contributing to improved patient care and outcomes

Conditions

• Pediatric Acute Respiratory Distress Syndrome (PARDS)
• Acute Respiratory Failure
• Acute Respiratory Distress Syndrome

Interventions

Type	Name	Description
OTHER	Fast method	Fast decremental catheter volume titration will be applied and optimal filling volume will be determined according to the measurements
OTHER	Conventional method	Conventional catheter volume titration will be applied and optimal filling volume will be determined according to the measurements

Timeline

• Start date: 2023-09-18
• Primary completion: 2025-11-30
• Completion: 2025-12-30
• First posted: 2023-09-22
• Last updated: 2025-03-20

Locations

4 sites across 1 country: Turkey (Türkiye)