NCT05958862

Stability of Driving Pressure Changes During "Best Positive End Expiratory Pressure (PEEP)" Trial

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to better understand in changes in lung compliance as indicated by driving pressure (a non-invasive marker) following changes in positive end expiratory pressure (PEEP; a standard of care ventilator parameter). The main question it aims to answer is: The time to stability of driving pressure after a change in PEEP is made Type of study: observational study participant population/health conditions Participants will undergo a "best PEEP trial" which is a standard intensive care intervention for patients undergoing invasive mechanical ventilation. This involves changing the patient's PEEP and looking for response in driving pressure. This will be done in a more protocolized format and data will be collected.

Conditions

• Acute Respiratory Failure
• Acute Respiratory Distress Syndrome

Timeline

• Start date: 2024-07-01
• Primary completion: 2024-12-31
• Completion: 2025-06-30
• First posted: 2023-07-25
• Last updated: 2024-11-25