NCT05872139

Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging

Influence of Exercise/Cardiorespiratory Fitness on Enhanced Endothelial Function With Aging: Role of Mitochondrial-derived Oxidative Stress

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: Ball State University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic exercise. In a double-blind, randomized, placebo-controlled crossover design participants with receive both MitoQ and placebo arm of the study. Primary endpoints will include vascular endothelial function assessed by brachial artery flow-mediated dilation and cardiac function assessed via pulse wave analysis. Secondary endpoints will include measures of aortic stiffness assessed by carotid-femoral pulse wave velocity and carotid artery stiffness (e.g. β-stiffness) and elasticity (carotid compliance, distensibility, and Youngs elastic modulus) from ultrasonography.

Conditions

• Aging
• Endothelial Dysfunction
• Cardiovascular Function
• Arterial Stiffness

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo	Gelatin capsules
DIETARY_SUPPLEMENT	Mitoquinone Mesylate	MitoQ was given once (single dose, 80 mg)

Timeline

• Start date: 2022-09-23
• Primary completion: 2023-04-17
• Completion: 2023-05-01
• First posted: 2023-05-24
• Last updated: 2023-05-24

Locations

1 site across 1 country: United States