NCT05756270

Clinical Applicability of pCASL as a Substitute for FDG-PET in MCI and SCD Patients

Clinical Applicability of Pseudo-continuous Arterial Spin Labeling as a Substitute for FDG-position Emission Tomography in MCI and SCD Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 150 (actual)
• Sponsor: University of Milano Bicocca · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to compare cerebral perfusion patterns with pseudo-continuous arterial spin labeling (pCASL) and brain metabolism patterns with fluorodeoxyglucose-position emission tomography (FDG-PET) in patients with mild cognitive impairment (MCI) and subjective cognitive decline (SCD). The main questions it aims to answer are: * Do pCASL sequences identify hypoperfusion patterns that correlate well with FDG-PET hypometabolic patterns? * Are there differences in this correlation in terms of cerebrospinal fluid (CSF) profiles? * Can hypoperfusion patterns in pCASL predict conversion to dementia? Participants will undergo brain 3 Tesla magnetic resonance imaging (MRI), FDG-PET, lumbal puncture and blood collection to analyze amyloid beta and tau, yearly detailed neuropsychological tests for three years.

Conditions

• Mild Cognitive Impairment
• Subjective Cognitive Decline

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	pCASL	Brain 3 Tesla MRI with pCASL sequence

Timeline

• Start date: 2022-06-03
• Primary completion: 2024-06-20
• Completion: 2026-03-01
• First posted: 2023-03-06
• Last updated: 2026-03-24

Locations

1 site across 1 country: Italy