NCT05754866

Transbronchial Lung Cryobiopsy in Undiagnosed Acute Respiratory Failure

Transbronchial Lung Biopsy Versus Transbronchial Lung Cryobiopsy in Critically Ill Patients With Undiagnosed Acute Hypoxemic Respiratory Failure: a Multicenter Prospective Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: China-Japan Friendship Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In patients with acute hypoxemic respiratory failure whose diagnosis is not established after initial evaluation, obtaining a histopathological diagnosis may improve the patients' prognosis. In our previous retrospective-controlled study, transbronchial lung cryobiopsy (TBLC) can lead to an increased chance of establishing a diagnosis compared with transbronchial lung biopsy (TBLB), with an acceptable safety profile. Therefore, further prospective randomized controlled studies exploring whether TBLC leads to improved prognosis for such patients are warranted.

Conditions

• Acute Respiratory Failure
• Acute Respiratory Distress Syndrome

Interventions

Type	Name	Description
PROCEDURE	Transbronchial lung cryobiopsy	Lung tissue was obtained by transbronchial lung cryobiopsy for subsequent pathology and clinical diagnosis.
PROCEDURE	Transbronchial lung biopsy	Lung tissue was obtained by transbronchial lung biopsy for subsequent pathology and clinical diagnosis.

Timeline

• Start date: 2023-04-01
• Primary completion: 2025-11-01
• Completion: 2025-11-30
• First posted: 2023-03-06
• Last updated: 2024-02-07

Locations

6 sites across 1 country: China