NCT05710874

A Prospective, Randomized, Clinical Study on the Effects of CPP-ACP-paste, Fluoride and a Combination on the Evolution of White Spot Lesions in Orthodontic Patients After Debonding.

A Prospective, Randomized, Clinical Study on the Effects of Casein Phosphopeptide Amorphous Calcium Phosphate Paste, Fluoride and a Combination on the Evolution of White Spot Lesions in Orthodontic Patients After Debonding.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 107 (actual)
• Sponsor: University Hospital, Ghent · Academic / Other
• Sex: All
• Age: 12 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The goal of this randomized clinical trial is to compare the influence of casein phosphopeptide amorphous calcium phosphate (CPP-ACP), CPP-ACP in combination with fluoride (CPP-ACPF), high fluoride concentration, and conventional fluoride toothpaste on the color and size of white spot lesions (WSLs) in orthodontic patients following bracket removal.

Conditions

• White Spot Lesion
• Orthodontic Appliance Complication

Interventions

Type	Name	Description
OTHER	CPP-ACP paste	Daily application of CPP-ACP (Casein phosphopeptide amorphous calcium phosphate) paste (Tooth Mousse®) in addition to twice daily use of conventional toothpaste.
OTHER	CPP-ACPF paste	Daily application of CPP-ACPF (Casein phosphopeptide amorphous calcium phosphate in combination with fluoridepaste) (MI Paste Plus®) in addition to twice daily use of conventional toothpaste.
OTHER	1.25% fluoride gel	Weekly application of 1.25% fluoride gel (Elmex Medical Gel®) in addition to twice daily use of conventional toothpaste.
OTHER	Conventional	Twice daily use of conventional toothpaste.

Timeline

• Start date: 2016-09-23
• Primary completion: 2023-03-29
• Completion: 2023-03-29
• First posted: 2023-02-02
• Last updated: 2023-08-24

Locations

1 site across 1 country: Belgium