| Not Yet Recruiting | Comparison of a 3-step Bonding System (Transbond™ XT) and a 2-step System (GC Ortho Connect™) on Demineralizat NCT07355322 | University Hospital, Montpellier | N/A |
| Not Yet Recruiting | Remineralization Effect Of Egg Shell Versus Fluoride Varnish On Early Carious White Spot Lesions In Primary Te NCT06932926 | Cairo University | Phase 2 |
| Not Yet Recruiting | PREVALENCE OF WHITE SPOT LESIONS IN ENAMEL AFTER ORTHODONTIC TREATMENT IN YOUNG ADULTS NCT06882304 | Cairo University | — |
| Active Not Recruiting | The Role of Fluoride Varnish Application in Preventing White Spot Lesions During Clear Aligner Treatment: A Co NCT07319884 | Mansoura University | N/A |
| Recruiting | Resin Infiltration Vs Self-Assembling Peptide (P11-4) in Treating White Spot Lesions NCT06708481 | October 6 University | EARLY_Phase 1 |
| Not Yet Recruiting | The Remineralization of Early Enamel Caries in Permanent Teeth NCT06358066 | Tanta University | Phase 1 |
| Unknown | The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients NCT06331442 | University of Zagreb | N/A |
| Recruiting | A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbio NCT06172764 | Dow University of Health Sciences | Phase 4 |
| Unknown | White Spot Lesions Treatment in Orthodontic NCT06051981 | Riyadh Elm University | Phase 4 |
| Recruiting | Air-polishing With Erythritol During Orthodontic Tretament NCT05989750 | Catherine Giannopoulou | N/A |
| Completed | İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin NCT06200129 | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | N/A |
| Completed | Effectiveness of Different Remineralizing Strategies on the Management of Early Carious Lesions in Primary Tee NCT06566833 | Alexandria University | EARLY_Phase 1 |
| Active Not Recruiting | The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients NCT06403371 | King Abdullah University Hospital | N/A |
| Unknown | Effect of Different Remineralization Gels NCT05868603 | Marmara University | N/A |
| Completed | Clinical Evaluation of an Experimental Remineralization Product NCT06166849 | Ivoclar Vivadent AG | N/A |
| Completed | Evaluation of Two Varnishes on the Improvement of White Spot Lesions in Children NCT05775250 | October University for Modern Sciences and Arts | N/A |
| Completed | Efficacy Evaluation of Two Different Fluoride Applications NCT06131294 | Ivoclar Vivadent AG | N/A |
| Unknown | Remineralizing Potential of Biomimetic Scaffolds on Enamel White Spot Lesions NCT05584878 | Hams Hamed Abdelrahman | N/A |
| Completed | Effect of Poly Amido Amine Dendrimer, Nano-hydroxyapatite NCT05771077 | Egymedicalpedia | Phase 1 |
| Unknown | Remineralizing Efficacy of Giomer Varnish vs. Fluoride Varnish in Management of White Spot Lesions in Adult Pa NCT05306691 | Cairo University | EARLY_Phase 1 |
| Completed | The Effect of Probiotic Lozenges on White Spot Lesion Development in Orthodontic Patients NCT05738369 | Jordan University of Science and Technology | N/A |
| Completed | Evaluation of White Spot Lesion Development Using 3 Orthodontic Adhesive Systems NCT05738356 | Jordan University of Science and Technology | N/A |
| Unknown | Clinical Evaluation of White Spot Lesions Treated by S-PRG and ICON NCT05550116 | Al-Azhar University | N/A |
| Completed | Effect of Different Biomimetic Materials on White Spot Lesions in Enamel NCT05001035 | Benha University | N/A |
| Completed | Home Remineralization of White Spot Lesions With Two Different Toothpastes. NCT04908293 | University of Pavia | N/A |
| Completed | Preventive Therapy of White Spot Lesions Using Different Remineralizing Agents in Children From 3 to 12 Years NCT04705428 | Universitat Internacional de Catalunya | N/A |
| Unknown | Performance of Different Resin Infiltration Materials on White Spot Lesions: Clinical and Laboratory Assessmen NCT04673097 | Imam Abdulrahman Bin Faisal University | N/A |
| Unknown | P11-4 and Nanosilver Fluoride Varnish in Treatment of White Spot Carious Lesions NCT04929509 | Hams Hamed Abdelrahman | N/A |
| Unknown | Remineralization Efficacy of Gum Arabic Varnish. NCT04422860 | Cairo University | Phase 2 / Phase 3 |
| Unknown | Evaluation of Remin Pro Forte Versus Remin Pro on Treatment of White Spot Lesions Post Orthodontic Treatment NCT04017884 | Cairo University | N/A |
| Completed | Self-assembling Peptide With Sodium Fluoride in Treating White Spot Lesionss in Primary Teeth NCT05721586 | Hams Hamed Abdelrahman | N/A |
| Completed | Effectiveness of MI Paste Plus and Remin Pro on Remineralization of Post-Orthodontic White Spot Lesions NCT06178042 | Izmir Katip Celebi University | N/A |
| Unknown | Remineralization Potential of Curodont Repair Flouride Plus Versus CPP-ACP in Management of White Spot Lesions NCT04245787 | Cairo University | N/A |
| Unknown | Remineralization Potential of Pearl Powder Compared to CPP-ACP on Enamel White Spot Lesions NCT03976583 | Cairo University | Phase 2 |
| Completed | Effect of Casein Phosphopeptide Amorphous Calcium Phosphate Fluoride Varnish on Remineralization of White Spot NCT03865680 | Nourhan M.Aly | Phase 2 |
| Withdrawn | Effectiveness of Resin-Modified Glass Ionomer Varnish in Preventing White Spot Lesions in Fixed Appliance Orth NCT03711097 | University of Nebraska | Phase 4 |
| Completed | Comparison of Remineralisation Efficacy of MI PASTE Plus® and REMIN PRO® for White Spot Lesions in Primary Tee NCT04382287 | Universidad Autonoma de San Luis Potosí | N/A |
| Completed | Effects of Active Reminders and Motivational Techniques on Oral Hygiene and Gingival Health in Orthodontic Pat NCT03841825 | Virginia Commonwealth University | N/A |
| Completed | Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients NCT04560478 | Texas A&M University | N/A |
| Unknown | The Effect of ICON Treatment on WPL With Patients After Fixed Orthodontic Appliances NCT03391180 | Riyadh Colleges of Dentistry and Pharmacy | N/A |
| Unknown | Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment NCT04342858 | The University of Hong Kong | Phase 2 |
| Completed | Fluoride Controlled-release System for Initial Lesions of Caries NCT05139966 | Federal University of Paraíba | Phase 2 / Phase 3 |
| Unknown | Evaluation of CPP-ACP Prophylactic Effect on Enamel Surface During Orthodontic Treatment NCT03187548 | Cairo University | Phase 1 |
| Completed | Evaluation of State and Shade of White Spot Lesions After Using Different Remineralizing Agents (An in Vivo St NCT04671134 | Al-Azhar University | N/A |
| Completed | Aesthetic Efficacy of Resin Infiltration Using Different Conditioning Methods: 24-Month Results NCT06259214 | Ondokuz Mayıs University | N/A |
| Unknown | Effect of Curodont Repair on Color Change of White Spot Lesions NCT02913885 | Cairo University | Phase 2 |
| Completed | A Prospective, Randomized, Clinical Study on the Effects of CPP-ACP-paste, Fluoride and a Combination on the E NCT05710874 | University Hospital, Ghent | N/A |
| Completed | Evaluation of Enamel Demineralization During Clear Aligner Orthodontic Treatment NCT04107012 | Jordan University of Science and Technology | N/A |
| Completed | Effect of CO2 Laser on Enamel White Spot Lesion Formation Around Orthodontic Brackets NCT03114475 | Damascus University | N/A |
| Completed | MI Varnish for the Prevention of White Spot Lesions NCT03446690 | University of Alabama at Birmingham | Phase 4 |
| Completed | Clinical Effectiveness of Various Professionally Applied Fluoride Prophylaxes in Groups at High Risk NCT02027922 | Medical University of Warsaw | N/A |
| Completed | Comparison of Three Toothpastes for the Prevention and Reduction of White Spot Lesions NCT03440996 | University of Alabama at Birmingham | N/A |