NCT05560945

2-year Caries Clinical Study: Arginine Fluoride-Free Toothpastes vs. NaF Toothpaste

Clinical Investigation Examining the Anticaries Efficacy of Three Dentifrices (1.5% Arginine in a Calcium Base, 8.0% Arginine in a Calcium Base, and 0.32% Sodium Fluoride in a Silica Base): a Two-year Caries Clinical Study

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 6,000 (actual)
• Sponsor: Colgate Palmolive · Industry
• Sex: All
• Age: 10 Years – 14 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to evaluate the anticaries efficacy for three dentifrices (1.5% arginine in a calcium base, 8.0% arginine in a calcium base, and 0.32% sodium fluoride in a silica base) in a two-year caries clinical study

Conditions

• Dental Caries

Interventions

Type	Name	Description
DRUG	0.32% Sodium Fluoride Dentifrice Toothpaste	Toothpaste
DRUG	1.5% Arginine Dentifrice	Toothpaste
DRUG	8.0% Arginine Dentifrice	Toothpaste

Timeline

• Start date: 2019-04-15
• Primary completion: 2022-03-12
• Completion: 2022-03-12
• First posted: 2022-09-30
• Last updated: 2022-10-03

Locations

3 sites across 1 country: China