NCT05535543

Change in the Phase III Slope of the Volumetric Capnography by Prone Positioning in Acute Respiratory Distress Syndrome

Assessment of the Effects of Prone Positioning Among ARDS Patients on Ventilation Homogenization by the Phase Iii Slope of the Volumetric Capnography

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Istanbul University - Cerrahpasa · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the effects of prone positioning on homogenization of ventilation.

Detailed description

After initiation of mechanical ventilation and assessing the eligibility of the patient, informed consent will be taken from the closest kin. If eligible, following steps will be performed which are part of standard ARDS patient care. 1. Low-flow Pressure Volume curve and assessment of airway opening pressure 2. Calculation of recruitment to inflation ratio 3. Optimizing Positive End-Expiratory Pressure Afterwards, phase III slope of the patient will be recorded at four timepoints: Supine 1 (immediately before turning to prone position) Prone 1 (immediately after prone position) Prone 2 (at the end of the 16-24 hour prone cycle) Supine 2 (immediately after turning to supine position)

Conditions

• Acute Respiratory Distress Syndrome
• Ventilation Perfusion Mismatch
• Respiratory Failure

Interventions

Type	Name	Description
PROCEDURE	Prone Positioning	Patients will be turned to prone position and they will be left in prone position for a duration of at least 16 hours to a maximum of 24 hours. This duration is recommended by the ARDS guidelines.

Timeline

• Start date: 2022-09-06
• Primary completion: 2025-01-30
• Completion: 2025-02-28
• First posted: 2022-09-10
• Last updated: 2024-07-03

Locations

1 site across 1 country: Turkey (Türkiye)