NCT05456802

Effect of Acute Cardiovascular Disease on Microbiome

The Influence of a Symptomatic Coronary Artery and Peripheral Arterial Disease on the Oral-enteral Microbiome and Downstream Microbiome-dependent Metabolites

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: University Hospital, Essen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Atherosclerotic diseases such as coronary artery disease (CAD) and peripheral arterial disease (PAD) are the leading cause of morbidity and mortality in the industrialized world. An interaction between the development of atherosclerotic diseases and the oral and enteral microbiome composition has already been demonstrated in the past. The microbiome is a double-edged sword which can convey protective and detrimental cardiovascular effects. While it can promote the development of atherosclerosis through the production of atherogenic metabolites such as trimethylamine N-oxide (TMAO) it can also generate a protective effect through the production of metabolites such as short chain fatty acids (SCFA). Preliminary data suggest that atherosclerotic disease itself can induce a dysbiosis of the microbiome. Aim of this study is to determine the differences in coronary artery disease and peripheral arterial disease on the oral-enteral microbiome axis and downstream microbiome-dependent metabolites.

Conditions

• Microbial Colonization
• Coronary Artery Disease
• Myocardial Infarction
• Acute Coronary Syndrome
• Peripheral Arterial Disease
• Critical Limb Ischemia

Interventions

Type	Name	Description
OTHER	Standard of care treatment	Standard of care treatment including percutaneous interventions was performed in all participants.

Timeline

• Start date: 2022-08-12
• Primary completion: 2024-02-01
• Completion: 2024-04-01
• First posted: 2022-07-13
• Last updated: 2024-09-24

Locations

1 site across 1 country: Germany